DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32137 and AgaP_AGAP001308

DIOPT Version :9

Sequence 1:	NP_729935.1	Gene:	CG32137 / 39537	FlyBaseID:	FBgn0052137	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	XP_321839.4	Gene:	AgaP_AGAP001308 / 1281869	VectorBaseID:	AGAP001308	Length:	559	Species:	Anopheles gambiae

Alignment Length:	564	Identity:	281/564 - (49%)
Similarity:	391/564 - (69%)	Gaps:	51/564 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 LEHYISAMEARRHD----QEPDVWAQLQQKESDILLAAELGKALLEKNEELVKQQEKLIEDYSSK 148
            ||.||..||.|..|    .|.||||||.|||:|:|||||||||||||||||.|.|||||:|||:|
Mosquito    11 LEDYILEMETRPPDSGQVMEKDVWAQLHQKEADLLLAAELGKALLEKNEELKKNQEKLIDDYSAK 75

  Fly   149 IEKLEQEKHVLRQKLAIAEDESDQRVLELQSDLTELKDKLQTQDTAIRQAEKEKTILIDELQHQN 213
            :|.|||||::|:::|.|:..|::..:||||.|:.:.:.||:.|:..:||.|:||.:||:||..||
Mosquito    76 VENLEQEKYILKRQLEISSSENEAIILELQGDIKQFRQKLEAQEQIMRQMEREKNMLIEELTAQN 140

  Fly   214 TRLTEQIQEAHATELKLSAQIQELKDQYHYRNSSLQEHVNSLESIKTELNLTTGKRQELERRLQI 278
            |||:.::|:::|||.:|:||:||:|:|.:.|..|:|:||:||||:|.||.|...|:.|||.||.:
Mosquito   141 TRLSNELQKSNATEQQLTAQLQEIKEQCNRRTLSIQDHVSSLESLKNELRLILEKKNELENRLHM 205

  Fly   279 AQEEKESLTSSLEESSDRIHMLERHAREQETKLETTLQALERSQRENNVLSERLGA-DTNSSTPG 342
            ...|:|:|:.:|.|:|:|||:|||..:||:||.:.|:|.|:|.:|||..|||||.: |:..|..|
Mosquito   206 TVSERENLSIALNEASERIHILERSTKEQDTKYQMTVQTLDRLERENGTLSERLESFDSQRSLHG 270

  Fly   343 ----RKSLQFEMECDED-DGSYTETGKPNQMFVEARSVYIQLKSLVDSLK-VSHDDDSGLNSDIS 401
                ..||..||..:|: .||..|..  :.:..||:|||.|||:|..:|: ..|||||||:||:|
Mosquito   271 ELQHHSSLLQEMNGEEECAGSKDEAS--HLVLKEAQSVYKQLKTLCQTLRSTHHDDDSGLHSDMS 333

  Fly   402 LELESMDNTI---------------SSSERHEDGHLAIEFRQGMLSSMSDELTRLLLNLDAGNFK 451
              ..|:|||:               |:|....|     :|.:||||:::|||...::||||..||
Mosquito   334 --FSSLDNTMAPVSMAAPNSVTEATSASMNVND-----KFSRGMLSAVADELVHTIMNLDAMQFK 391

  Fly   452 KMLDQTRNLVLEQEDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARGDLEDNT-DRDELLSK 515
            .|.:|||::::|||:|:|:.:.:|.|||:|::|.:||||:..|||:|||.|...:: .:||.:.:
Mosquito   392 TMFEQTRSMLIEQEEELKKKNDVIMQLESKLSVREVELQSTIEERNQAREDASHSSLAQDETVVQ 456

  Fly   516 AQTERDAANDRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLEQWQMDMHELIDEQMRSK 580
            |:.:||||.:|||||||||||.|||||||||||||:|||||||.|||||||:||||||:|||::|
Mosquito   457 ARKDRDAAIERRTKAEVELAKNRVELMQANSQLLEAIQQKVELLQQLEQWQIDMHELIEEQMKNK 521

  Fly   581 LINNRRAMAAESSAP------SPPSSAAANLAKRVTSYKLWSLF 618
            ||.:       |:.|      |..||.|:....|.:  :|..||
Mosquito   522 LIES-------STKPQQHQQQSQQSSGASTTGSRKS--RLLDLF 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32137	NP_729935.1	DUF4337	<105..>172	CDD:290935	47/66 (71%)
AgaP_AGAP001308	XP_321839.4	SMC_prok_B	<27..>287	CDD:274008	135/259 (52%)
AgaP_AGAP001308	XP_321839.4	SMC_prok_B	160..>521	CDD:274008	184/369 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	479	1.000	Domainoid score	I1389
eggNOG	1	0.900	-	-		E1_2BWXB
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18013
Inparanoid	1	1.050	479	1.000	Inparanoid score	I3224
OMA	1	1.010	-	-		QHG46829
OrthoDB	1	1.010	-	-		D269681at33208
OrthoFinder	1	1.000	-	-		FOG0002987
OrthoInspector	1	1.000	-	-		otm51217
Panther	1	1.100	-	-	LDO	PTHR32123
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5076
TreeFam	1	0.960	-	-
	13	12.940