DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and CEP350

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_011508493.1	Gene:	CEP350 / 9857	HGNCID:	24238	Length:	3189	Species:	Homo sapiens

Alignment Length:	1345	Identity:	246/1345 - (18%)
Similarity:	457/1345 - (33%)	Gaps:	442/1345 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RLLEAAPGSRRSIED---VSGA------------TPTAAQPTKARLSSSR----TSLSSSRQSLL 119
            ::.|.|..:|..|.|   .|||            .|...:..:.|..:.|    .|||.|::..|
Human  1451 QICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDRKSPSVSLSQSKEGTL 1515

  Fly   120 GSRTQLTTSLSERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASF 184
            .|:.|..::..:..:.||........:...|..:||||....:.......|....|....:
Human  1516 DSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKENEKKLNGEKIESSIDEQ---- 1576

  Fly   185 VETGFLEILKPQFTPSQP-------------------LRSPSFTMPSNSGAEDKVAL-------L 223
            |:|...:.|:....||.|                   .|.|......|:|..|..::       .
Human  1577 VQTAADDSLRSDSVPSLPDEKETGSCSVTQAGLELLASRDPPTLASQNAGITDSTSIATEYSLKF 1641

  Fly   224 EAQKTSAELQAQ-----LADLTEKLETLKQRRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQ-- 281
            :...|..|::.|     |...:.:...:::||....:...|....|......:|......|.|
Human  1642 DESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDS 1706

  Fly   282 -------------------ASLQKELLRAKQEA-KDAIEAK----EQHAQEMADLADNVEMITLD 322
                               |:.|..|||.:::| |:..:|:    |...:.:.|..::.:|..|.
Human  1707 FSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR 1771

  Fly   323 KEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQ---NKAESAIGNISGGGDSPGLSTYEFK 384
            |     |...|.|.|:..|..|:.|:...:..|.|.|   .:.|                  |.:
Human  1772 K-----KQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQE------------------EIE 1813

  Fly   385 QLEQQNIRLKETLVRLRD--LSAHDKHDIQ--------------KLSKELEMKRSEVTELERTKE 433
            ::.|..|:|:|.|....:  |.:|...|.:              :....:.:..||.:.:.:..:
Human  1814 KIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLK 1878

  Fly   434 KLSAKIDE------------------------------------LEAIVADLQEQVDAALGAEEM 462
            |:.:::||                                    ...:|..|.::....:...:.
Human  1879 KMRSRMDEKHCSPVHYFFSVFTSHHWASLSVCFPNLHPKFQLYIYNQLVRFLTKREQKLMQRRQH 1943

  Fly   463 VEQLAEKKMELEDKVKLLEEEIAQLE--ALEEVHEQLVE---SNHELELDLREELDLANGAKKEV 522
            .|:|.|.|..|:.:    |.||.|:|  ||....::|::   ...||| |.|.|       :||:
Human  1944 AEELLEWKRRLDAE----EAEIRQMEKQALAAWDKELIKPKTPKKELE-DQRTE-------QKEI 1996

  Fly   523 LRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMV-TETIDYKQM 586
            ..|.::.:              .|...||.:         |:..|.|..|:::.| :|:|..:|
Human  1997 ASEEESPV--------------PLYSHLNSE---------SSIPEELGSPAVEYVPSESIGQEQ- 2037

  Fly   587 FAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVV 651
                                              |.|     .||..:...::.|:   :.:...
Human  2038 ----------------------------------PGS-----PDHSILTEEMICSQ---ELESST 2060

  Fly   652 SQTRERFP-PVDAITREAVTQGHAVQQYAFKCRLLHYVHSL--QCAL----HQILYGLNSCQPDT 709
            |.::...| ...:::::..::|.               |..  ||.|    ||..|   |...::
Human  2061 SPSKHSLPKSCTSVSKQESSKGS---------------HRTGGQCHLPIKSHQHCY---SWSDES 2107

  Fly   710 LLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQM 774
            |....|   |..:.:..::|.|..||.......|..:.::|               ||...:.:.
Human  2108 LSMTQS---ETTSDQSDIEGRIRALKDELRKRKSVVNQLKK---------------EQKKRQKER 2154

  Fly   775 IRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLPSDQH 839
            ::...|||....||.  |..|.|.   ||..:.|.        |...:.:.|:|.:..  .|::.
Human  2155 LKAQEASLIKQLESY--DEFIKKT---EAELSQDL--------ETSPTAKPQIKTLSS--ASEKP 2204

  Fly   840 VIKSGLSQHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESD-NAAEHTLPQEKYWALLTA 903
            .||.....|:.|.    |:|...:..:  :.::.||.:|...:::. :.:|.::.:..    |:|
Human  2205 KIKPLTPLHRSET----AKNWKSLTES--ERSRGSLESIAEHVDASLSGSERSVSERS----LSA 2259

  Fly   904 SCERIYEQDDRGPTQNFKT----------LLAQANSDLQLI-AQHLLDKEYDIISAANNASNQQK 957
            ..:|:.|.|.|  |::|:|          :..::...|:.: |.||| ||.:..|...:.|: .|
Human  2260 YAKRVNEWDSR--TEDFQTPSPVLRSSRKIREESGDSLENVPALHLL-KELNATSRILDMSD-GK 2320

  Fly   958 SGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQLKVAAK--MKQNELSEMQIRKDL---- 1016
            .|..|    :::::  |::|...:..:.:|:..:...:..|..|  ::|.:.||:..:|||
Human  2321 VGESS----KKSEI--KEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLDS 2379

  Fly  1017 --AEKKLSVLQNEYEHAVDKWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLK 1079
              .:|.|..|..|..|       |.||     .|||::.::.|:|
Human  2380 ENVQKDLVGLAIENLH-------KSEE-----MLKERQSDQDMNH-------------------- 2412

  Fly  1080 LNSTTGKVQPGSESHSPHNISLSGNTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQERNQR 1144
                :..:|.|.:.|...|
Human  2413 ----SPNIQSGKDIHEQKN---------------------------------------------- 2427

  Fly  1145 LRLQAQDMRAKLSQFEPLHVPQPQDQRITALESELTRMKHA---WVLSLLQVRSQDSVNSGTRID 1206
              .:.:|:......|.|..:|..:|..:::.:.|::...:.   .|.|||.:| :||.:.
Human  2428 --TKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLR-KDSQSC----- 2484

  Fly  1207 AVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKP---HRATH 1248
                  |::|.|::...|...|..:::.::|.|..|.   |...|
Human  2485 ------RDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVH 2523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	246/1345 (18%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	49/288 (17%)
CEP350	XP_011508493.1	CAP_GLY	2572..2635	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900