Protein Alignment DCTN1-p150 and NIP100

DIOPT Version :9

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_015151.1
• Gene: NIP100 / 855929
• SGDID: S000006095
• Length: 868
• Species: Saccharomyces cerevisiae
• Alignment Length: 1168
• Identity: 216/1168 - (18%)
• Similarity: 387/1168 - (33%)
• Gaps: 419/1168 - (35%)

  Fly     7 KVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFVRPT 71
            |:..:..:...::.|.|.::|.|.||.|.|.|:.||:|.|||.||..|.:||..|
Yeast    14 KISLQDTVLVNEMKGRVKFIGETQFAKGIWYGIELDKPLGKNDGSANGIRYFDID---------- 68

  Fly    72 QLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSERTASS 136
                                                                             
Yeast    69 ----------------------------------------------------------------- 68

  Fly   137 SSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKPQFTPSQ 201
                    |...||                 :||         ....|.:...|:..||.
Yeast    69 --------LKKANS-----------------NGG---------YYGLFCKKDTLQFYKPD----- 94

  Fly   202 PLRSPSFTMPSNSGAEDKVALLE---AQKTSAELQAQLADLTEKLETLKQRRNEDKERLREFDKM 263
                           :|:.:||.   ||:|...||.:...|..||..:|...:|          :
Yeast    95 ---------------DDEHSLLNGNAAQETIKNLQVKCESLASKLNKIKIENHE----------L 134

  Fly   264 KIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKEMAEE 328
            |...|:|....|.::...:.|.|.:...|.| ...::....:...:.|.:|:|....|||....|
Yeast   135 KTSVEKLSTNETVLLSKISRLDKLVKELKVE-NGNMKTHLDNFNHLLDASDSVMAPDLDKGTLLE 198

  Fly   329 KADTLQLELESSKERIEE-LEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQNIR 392
            ::..||..|:.:|...:: ::|..:||....|...|:|:
Yeast   199 RSHLLQGLLDQTKLSYDKAMKVQEDLLEENTQLLEENAV-------------------------- 237

  Fly   393 LKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVDAAL 457
                                 |||::              ..|..::.:....:.||..|::|..
Yeast   238 ---------------------LSKKI--------------SDLGLQLQQTNNTIGDLALQIEAQS 267

  Fly   458 GAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGA---K 519
            .:..:|::|....:.|...:|.|..|:.:|:|.|::.|.|..:..:||.:||.:|.....|   :
Yeast   268 KSSNIVDKLTNDNILLTSNIKALNNELEELQAKEKLDENLRITYEQLEQELRLQLSNLQSALENE 332

  Fly   520 KEV----LRERD---AAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEK-----ESLQDP 572
            ||:    :.|..   |.:|:|  ..:|..||:.|..|:|....||. :|...:|     |....|
Yeast   333 KEIAGTYIEENSRLKATLESI--EAKTSHKFQSLELKVNTLQEELY-QNKLLKKFYQIYEPFAQP 394

  Fly   573 SLKMVTETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVI 637
            .|..::..:.|.....||:.:.:     |..||:     |:                      ::
Yeast   395 HLAALSSQLQYLAEVIESENFGK-----LENIEI-----HI----------------------IL 427

  Fly   638 LLISRIVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGL 702
            .::|.|                            .:|:..|..|....|...:|||....|. .:
Yeast   428 KVLSSI----------------------------SYALHIYTIKNTPDHLETTLQCFKVNIA-PI 463

  Fly   703 NSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQ-LDENST----------TDNIEKCVAF-- 754
            :....:.|.|..||      :::....|.:.|:.|: ||::.|          ...:.|.:||
Yeast   464 SMWLSEFLQRKFSS------KQETAFSICQFLEDNKFLDKDVTLILKILHPILETTVPKLLAFLR 522

  Fly   755 ----FNAMNSVLLAGEQLLNEIQMIRDCVASLGAACESILSDTAIAK-----VIIQEAGATSDSV 810
                ||..:::.|.|......:.:|        |..:.::....|:|     .:......|..|:
Yeast   523 TNSNFNDNDTLCLIGSLYERSLSLI--------ARIDKLIGKEEISKQDNRLFLYPSCDITLSSI 579

  Fly   811 LLIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLSQHKV--EAMRGLAQNISRIMSAMHQATKQ 873
            |.|.|  .:...:||..|.|            |.|.:.:|  :.:..|.:||:.......|.|
Yeast   580 LTILF--SDALFLRQDYKRI------------SSLKKLEVFFQGIESLLENITIFPEQPSQQT-- 628

  Fly   874 SLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSDLQ------ 932
                      ||:.::..:.:..:...|.:  :|:.|::.|     .|.:|.|..:.|.
Yeast   629 ----------SDSESQCNIKEGNFSNSLLS--DRLNEENIR-----LKEVLVQKENMLTELETKI 676

  Fly   933 --LIAQHL----LDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREA 991
              :|.:.|    |::....:....|..|::..|        :.:::.|..|:...|...|:|.|.
Yeast   677 KIIIGRDLERKTLEENIKTLKVELNNKNEENCG--------KTEILNKLKEENFNLVNRLKNMEL 733

  Fly   992 DVKQLKVAAKMKQ--------------NELSEMQ--IRKDLAEKK-----------LSVLQNE-- 1027
            .:.|:|....:.:              :|:.|::  ||:.:.|:|           |..::|:
Yeast   734 KLYQIKDNNTLNKIYLDREKVDRVNLVSEIMELRETIRRQIKEQKRVSIDFSWLDELPAVENKQP 798

  Fly  1028 ----YEHAVDKW---KQKYEETSLQLQLK------EKEFEETMDHLQSDIDALESEKSDLRDK 1077
                ..|::|..   ...:..||..|.||      |.|.....||  |.|..|:.::.::|.|
Yeast   799 FKEHINHSLDTLGIEMFNFVSTSRILDLKLDQPLAEDELWHERDH--SYISYLKRKRKNIRLK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	21/65 (32%)
		Dynactin	553..834	CDD:289240	54/307 (18%)
NIP100	NP_015151.1	NIP100	12..828	CDD:227569	206/1133 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I2622
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030