DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and BIK1

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_009901.1	Gene:	BIK1 / 850328	SGDID:	S000000534	Length:	440	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	116/501 - (23%)
Similarity:	188/501 - (37%)	Gaps:	121/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEKNLKVGARVEL--TGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCD-E 62
            |.....|:|..:::  .|:   |.:.|||......|.:.||.|....|||.||..|::|||.: .
Yeast     1 MDRYQRKIGCFIQIPNLGR---GQLKYVGPVDTKAGMFAGVDLLANIGKNDGSFMGKKYFQTEYP 62

  Fly    63 NCGMFVRPTQL-RLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLT 126
            ..|:|::..:: .|:|.|..|:                |..|.:....|:..:|     |..:||
Yeast    63 QSGLFIQLQKVASLIEKASISQ----------------TSRRTTMEPLSIPKNR-----SIVRLT 106

  Fly   127 TSLSERTASSSSIGPRKSL-------APQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASF 184
            ...|......|.. |.:|.       ..|.|.|:|            ||..:.........|...
Yeast   107 NQFSPMDDPKSPT-PMRSFRITSRHSGNQQSMDQE------------ASDHHQQQEFGYDNREDR 158

  Fly   185 VETGFLEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAEL-QAQLADLTEKLETLKQ 248
            :|..  .||......:.  .:.|...|.|....|    |.:.:.:.|| :|||.  .|||    |
Yeast   159 MEVD--SILSSDRKANH--NTTSDWKPDNGHMND----LNSSEVTIELREAQLT--IEKL----Q 209

  Fly   249 RRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLA 313
            |:....:||  .|..::..|::|....:........:||:...||:.:  :|.::|..|:....|
Yeast   210 RKQLHYKRL--LDDQRMVLEEVQPTFDRYEATIQEREKEIDHLKQQLE--LERRQQAKQKQFFDA 270

  Fly   314 DNVEMITLDKEMAEEKADTLQLELE-----SSKERIEELEVDLELLRS-EMQ---NKAESAIGNI 369
            :|.:::.:..::.||..:..:..|.     .:.|.:|.|:..||.||: |.|   :|.:.|
Yeast   271 ENEQLLAVVSQLHEEIKENEERNLSHNQPTGANEDVELLKKQLEQLRNIEDQFELHKTKWA---- 331

  Fly   370 SGGGDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKEL------EMKRSEVTEL 428
                       .|.:||:..|..|.:              :.|.|||||      :....||..|
Yeast   332 -----------KEREQLKMHNDSLSK--------------EYQNLSKELFLTKPQDSSSEEVASL 371

  Fly   429 ERTKEKLSAKIDELEAIVA----------DLQEQVDAALGAEEMVE 464
            .:..|:.:.||.:||...|          |....||...|.::..|
Yeast   372 TKKLEEANEKIKQLEQAQAQTAVESLPIFDPPAPVDTTAGRQQWCE 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	21/69 (30%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240
BIK1	NP_009901.1	CAP_GLY	8..73	CDD:396049	21/67 (31%)
BIK1	NP_009901.1	SMC_prok_B	193..>395	CDD:274008	58/240 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18916
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030