Protein Alignment DCTN1-p150 and clip1a

DIOPT Version :9

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_009300267.1
• Gene: clip1a / 797680
• ZFINID: ZDB-GENE-060526-282
• Length: 1569
• Species: Danio rerio
• Alignment Length: 1438
• Identity: 303/1438 - (21%)
• Similarity: 545/1438 - (37%)
• Gaps: 433/1438 - (30%)

  Fly     4 KNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFV 68
            :..|||.||.:.| :..|.|.::|.|.||.|:|.|:|||||.|||.||:.|.:||||:...|:|.
Zfish    50 EQFKVGDRVWVNG-NKPGVVQFLGETQFAPGQWAGIVLDEPIGKNDGSVSGVRYFQCEALRGIFT 113

  Fly    69 RPTQLRLLE-------AAPGSRR-----SIEDVSGATPTAAQPTKARL---------SSSRTSLS 112
            ||::|...|       .||.||.     |...||.::...|.||||..         |.|.::||
Zfish   114 RPSKLSSTEGEADGTTTAPPSRAASPTPSTTSVSASSKKPASPTKAAAPTSDLVRSKSESVSNLS 178

  Fly   113 SS--------------RQSLLGSRTQLTTSLSERTASSSS-----------------IGPR---- 142
            .|              |..:.||:..:...|.|...:...                 .|.|
Zfish   179 ESGSVKKGERELKINDRVLVAGSKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC 243

  Fly   143 ------------------KSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGF 189
                              .|..|..:|.....:|:.....|:|...:.:||..||..:
Zfish   244 QPKYGLFAPVHKVTRIGFPSTTPAKAKTTVRKTTATTAATPSALKRSPSASSISSMSS------- 301

  Fly   190 LEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDK 254
                         :.|.:...||.:|      ||  .:||.....:::..|...|.||:::...:
Zfish   302 -------------VASSASCKPSRTG------LL--TETSTRYSRKISGTTALQEALKEKQQHIE 345

  Fly   255 ERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMI 319
            :.|.|.|..:.:..:    .|..:| :...:..|||         |.:||:|.|:.|..|.:..:
Zfish   346 QLLAERDLERAEVAK----ATNHVG-EVEQELTLLR---------EGQEQYASEVNDKMDQLRAL 396

  Fly   320 TLDKEMAEEKADTLQLELESSKERIEELEVDLE---LLRS--EMQNKAESAIGNISGGGDSPGLS 379
            .   |.|:.:...|..:||..|.::|:|:..:|   :.:.  |.|.:.|.|:
Zfish   397 V---EAADREKVELLNQLEEEKRKVEDLQFRVEEACITKGDLETQTQLEHAL------------- 445

  Fly   380 TYEFKQLEQQNI-------RLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSA 437
               .|:|||..:       :|:..|...|..:..:|..|.:|.::|.||..|...|.::.|.||:
Zfish   446 ---LKELEQSLLFEKTKAEKLQRELEDSRVATVSEKSRILELERDLSMKDKESAALRKSLEALSS 507

  Fly   438 KIDELEAIVADLQEQV--------------DAALGA----------------------------- 459
            :....::.||.||||:              .|.|.:
Zfish   508 QDGVCDSAVAALQEQLSLIRSQQAEQSHSHQAELSSMREKLEAQEKAHREALMHLQASSSRLSKD 572

  Fly   460 -EEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVE---------------------SNH 502
             |:::.:||:.|   |:...::|:...:|:::|..|:|.:|                     |.|
Zfish   573 NEQLLAELAKSK---EENSNVVEQWSDKLKSVEASHQQALEELKTSREASKAELSDALERLKSTH 634

  Fly   503 ELELDLREELDLANGAKK----------EVLRERDAAIETIYDRDQTIVKFRELVQKLNDQ-LTE 556
            :|||   |||     |||          |.:..:...::...:.::.:...|..::|..:| |.|
Zfish   635 KLEL---EEL-----AKKHSSEAAGWVGEGMEHKAQLLKVAEENERQVEMLRSSLEKAEEQHLVE 691

  Fly   557 LRD-----RNSSNEKESLQDPSLKMVTETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQML 616
            |.|     ..:....:.|:|..:| ::|.:  |:...|:...:.|:  |..|.:.||.|:.:|.|
Zfish   692 LEDAMGKLHAAELRVKELEDSGVK-ISEQL--KEKVQEALEQSEAL--QSLQTQHSQGNQEMQRL 751

  Fly   617 TAFMPESFMSRGGDHDSILVILLISRIVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFK 681
            .:.:.|:                           .|:.|.:        .|.||:.::|.:
Zfish   752 LSQVEEA---------------------------KSKARSQ--------EEKVTELNSVLE---- 777

  Fly   682 CRLLHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLPEMVA-----QEKIVDGIIELLKSNQLDE 741
                        ...|.|.|        ||:..|||.:.|:     .||..:...:..::||..:
Zfish   778 ------------VKQQELSG--------LLQEKSSLEQEVSLLKQNLEKTTNDQAKSSQTNQELQ 822

  Fly   742 NSTTDNIEKCVAFFNAMNSV--LLAGEQLLNEIQMIRDCVASLGAACESIL----SDTAIAKVII 800
            ....:..:||.:....:...  .|||.|            .||.|:.|..|    ..|.:...|:
Zfish   823 EELRNKEDKCTSLSAELQDTKSQLAGLQ------------RSLKASEERCLLLTKDKTKLENDIM 875

  Fly   801 QEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLSQHKVEAMRGLAQNISRIMS 865
            ....::.||..||..|||..:....:::.::::|..::.  |:..::.|:...|...:|.::.:.
Zfish   876 DMTKSSGDSSTLITKLNEENKRKEGRLEELQKQLEEERE--KTAQTEEKLSHTRVQTENEAKSLM 938

  Fly   866 AMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSD 930
            ..|||...:|...:..:|......|...::     |.||.|:..            |..|:.:|.
Zfish   939 QKHQAELANLQEKIKLLEKSIEDNHAKAKD-----LHASGEKAL------------TDAAELHSK 986

  Fly   931 LQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQ 995
            .:...|...:|....:||:.|.|.:                ::||:|:    ..|.:.:.|.:::
Zfish   987 EKQELQSKYEKVQQELSASQNESLE----------------LRKQIEE----LMTFKEKTAVLEK 1031

  Fly   996 LKVAAKMKQNELSE--MQIRKDL--AEKKLSVLQN---EYEHAVDKWKQ---KYEET----SLQL 1046
            .:.||:....::::  :|::||.  :|.:::.|:|   |.:..:|..||   :|||:    ..::
Zfish  1032 AEEAARASLEKMTQDNLQLQKDKSDSEAQVTALRNTVQEMQSKLDALKQQNTQYEESLSSDGQRI 1096

  Fly  1047 QLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNISLSGNTSTAPGI 1111
            ....||.|        |:....:|||...|.|| |.....|...:.||...||.|:
Zfish  1097 SSLSKEIE--------DLKQAVAEKSQAVDDLK-NEKEKLVVDLANSHKDSNIILN--------- 1143

  Fly  1112 SNVSYSAPAGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMRAKLSQFEPLH----VPQPQDQRI 1172
                          :.:|.:.|.....:.:.:....:::..:.|.:..:.|.    :...:|:.:
Zfish  1144 --------------LKKECDRLNEQLKEAKTRESSFRSESEKEKAALQQTLQTQSGLVSEKDKEL 1194

  Fly  1173 TALESELTRMKHAWVLSLLQVRSQDSVNSGT-RIDAV---------ALQRRNQPV-PLKGEISSK 1226
            .:|.:||..:|..      ..:.|:|::|.: ||:::         |...::|.| .||.|....
Zfish  1195 NSLRNELDALKQQ------NSQYQESLSSDSERINSLSKEIEELKQAAVEKSQAVDDLKNEKEKL 1253

  Fly  1227 ASQLASDI 1234
            ...||:.:
Zfish  1254 TMDLANSL 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	33/65 (51%)
		Dynactin	553..834	CDD:289240	59/297 (20%)
clip1a	XP_009300267.1	CAP_GLY	55..118	CDD:279625	32/63 (51%)
		CAP_GLY	193..256	CDD:279625	7/62 (11%)
		Smc	<333..1004	CDD:224117	161/809 (20%)
		SCP-1	709..1402	CDD:114219	137/706 (19%)
		COG7	720..>871	CDD:287200	42/225 (19%)
		SPEC	940..1119	CDD:295325	46/223 (21%)
		GluZincin	1227..>1365	CDD:301352	8/35 (23%)
		CLIP1_ZNF	1507..1524	CDD:293247
		CLIP1_ZNF	1547..1563	CDD:293247

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840