DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and CLIP4

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001274456.1	Gene:	CLIP4 / 79745	HGNCID:	26108	Length:	705	Species:	Homo sapiens

Alignment Length:	429	Identity:	106/429 - (24%)
Similarity:	159/429 - (37%)	Gaps:	132/429 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCG 65
            ::...||:|.||.:.|:. :||:.:.|.|.||.|:|.|:.||||:|||:||:...|||:|....|
Human   278 LTSLGLKLGDRVVIAGQK-VGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYG 341

  Fly    66 MFVRPTQLRLLEAAPGSRRSIEDVSGATPT--AAQP----------------TKARLSSSRTSLS 112
            :|   ..|..:..|.|.|::|..    ||:  ||.|                ....::|.:.|.|
Human   342 IF---APLSKISKAKGRRKNITH----TPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSAS 399

  Fly   113 SSRQSL-----LGSRTQLTTSLSERTASSSSIG--------PRKSLAPQNSKDKESPSTSLAEGA 164
            .|..||     |.:.|:...:|....:|.||..        |:|..|..::|...|.|.||:..|
Human   400 ESTLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRA 464

  Fly   165 PAASGGNGAASHASSKRAS---------------------FVETGF-------LEILKP------ 195
             :|...:.|.|.|::.|..                     |..|.|       :|:.||
Human   465 -SAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDG 528

  Fly   196 -----QFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKE 255
                 |:....| |...|..||                      ::..:|:.|:||.
Human   529 SVGGVQYFSCSP-RYGIFAPPS----------------------RVQRVTDSLDTLS-------- 562

  Fly   256 RLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLR--AKQEAKDAIEAKEQHAQEMADLADNVE- 317
               |....| |......||.......||.|||:.|  |..::|.|:............:..:|:
Human   563 ---EISSNK-QNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKL 623

  Fly   318 ------MITLDKEMAEEK---------ADTLQLELESSK 341
                  ::|...||...:         ...|.|||.|:|
Human   624 HEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	28/65 (43%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240
CLIP4	NP_001274456.1	ANK 1	65..101
		ANK	98..252	CDD:238125
		ANK repeat	109..146	CDD:293786
		ANK 2	149..180
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK 3	186..215
		CAP_GLY	285..349	CDD:307465	29/67 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..479		13/48 (27%)
		CAP_GLY	487..551	CDD:307465	12/86 (14%)
		CAP_GLY	626..690	CDD:307465	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810