DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and CLIP2

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_003379.4	Gene:	CLIP2 / 7461	HGNCID:	2586	Length:	1046	Species:	Homo sapiens

Alignment Length:	983	Identity:	225/983 - (22%)
Similarity:	395/983 - (40%)	Gaps:	249/983 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMF 67
            ||:|::|.|| |.|....|.|.|||.|.||.|:|.||.||||.|||.|::.|.:||||....|:|
Human   216 EKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLF 279

  Fly    68 VRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSER 132
            . |....:....|.:          :|..|:.|| |::...::|:.|..|         :|:|..
Human   280 A-PIHKVIRIGFPST----------SPAKAKKTK-RMAMGVSALTHSPSS---------SSISSV 323

  Fly   133 TASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVE--TGFLEILK- 194
            ::.:||:|.|             ||.|            |..:..||:.|..:.  |...|.||
Human   324 SSVASSVGGR-------------PSRS------------GLLTETSSRYARKISGTTALQEALKE 363

  Fly   195 -----PQFTPSQPLRSPSFTMPSN--SGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNE 252
                 .|....:.|........::  ...|.::|||:||.     :..:|:..|||    ||...
Human   364 KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH-----EQYVAEAEEKL----QRARL 419

  Fly   253 DKERLREFDKMKIQF-EQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNV 316
            ..|.:|   |.|:.. .||:|.|.|:...|..:::|.:     .|..:|.:.|  .|.|.:.:..
Human   420 LVESVR---KEKVDLSNQLEEERRKVEDLQFRVEEESI-----TKGDLETQTQ--LEHARIGELE 474

  Fly   317 EMITLDKEMAE----EKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPG 377
            :.:.|:|..||    |.||. :|...:.|.|:.:||.:|.|.|.|::...:..:.:.....|.|.
Human   475 QSLLLEKAQAERLLRELADN-RLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPD 538

  Fly   378 LSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQ------KLSKELEMKRSEVTELERTKEKLS 436
            .:         :.:||:|.|     |||..:|..:      |..|.|:..::||.:|....||.:
Human   539 AA---------EILRLRERL-----LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYA 589

  Fly   437 AKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESN 501
            .::                 .|.::.|:|...:.|.|.|..|      ::|::|...|::.:|
Human   590 QEV-----------------AGLKDKVQQATSENMGLMDNWK------SKLDSLASDHQKSLE-- 629

  Fly   502 HELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVKFREL--VQKLNDQLTELRDRNSSN 564
                 ||:..|:...||:::.:.|..|.:|.|....|.     ||  :|..:|..|.:..:....
Human   630 -----DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQL-----ELGNLQAKHDLETAMHVKEKEA 684

  Fly   565 EKESLQDPSLKMVTETIDYKQMFAESKAYTRA-IDVQLRQ--IELSQANEH---VQMLTAFMPES 623
            .:|.||:.           ::..|..:.:.|| ::||..|  :||.:|.:.   .::....:.:.
Human   685 LREKLQEA-----------QEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 738

  Fly   624 FMSRGGDHDSILVILLISRIVFKCDIVVSQTR----ERFPPVDAITREAVTQGHAVQQYAFKCRL 684
            .:...|...:|..:        |..|.:::.:    ||....:|..::.|.        :.:.:|
Human   739 DVEYRGQAQAIEFL--------KEQISLAEKKMLDYERLQRAEAQGKQEVE--------SLREKL 787

  Fly   685 LHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIE 749
            |...:.||.     :..|.|.|...::.:.....|.:..::.|:|:.:.|.....:..:.|...|
Human   788 LVAENRLQA-----VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE 847

  Fly   750 KCVAFFNAMNSVLLAGEQ----LLNEIQMIRDCVASLGAACESILSDTAIA---------KVIIQ 801
            ...|..:|:.|...:||:    ||.|.:       .|.|..|::...|..|         :::.:
Human   848 MLRAQVSALESKCKSGEKKVDALLKEKR-------RLEAELETVSRKTHDASGQLVLISQELLRK 905

  Fly   802 EAGATSDSVLLI--------------------------QFLNENMESVRQQVK-LIKRRLPSDQH 839
            |.......|||:                          |.|.:::..:|:::. |.|.:..|||.
Human   906 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQR 970

  Fly   840 ----VIKSGLS-----QHKV----EAMRGL---AQNISRIMSAMHQATKQSLAAIVSTIESDNAA 888
                :.:|...     ||::    :|:|..   ||.:.::|.||.....::     .||.:..:|
Human   971 RYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKA-----QTIGNSGSA 1030

  Fly   889 EHTLPQEK 896
            .....|:|
Human  1031 NGIHQQDK 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	33/65 (51%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	56/330 (17%)
CLIP2	NP_003379.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		CAP_GLY	81..145	CDD:366568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..215
		CAP_GLY	221..285	CDD:366568	33/65 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..339		11/59 (19%)
		Smc	<357..971	CDD:224117	151/721 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1046		5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840