DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and Cep350

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	XP_006529963.1	Gene:	Cep350 / 74081	MGIID:	1921331	Length:	3140	Species:	Mus musculus

Alignment Length:	1340	Identity:	248/1340 - (18%)
Similarity:	466/1340 - (34%)	Gaps:	390/1340 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 KARLSS--------SRTSLSSSRQSLLGSRTQLTTSLSERT----ASSSSIGPRKSLAPQNS--- 150
            |.||.:        .:.:|::..:.|:..||......|:||    .:|....|..|.:|:||
Mouse  1918 KRRLDAEEAEIQQMEKQALAAWDKELVKPRTPKKEQESQRTEQKGIASEEGSPMPSYSPRNSESC 1982

  Fly   151 --KDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP-QFTPSQ----------- 201
              :|..|||..............|:..| |:.....|.:..||...| :.:|.:
Mouse  1983 IPEDLGSPSDLCVPSEARVQAQPGSPEH-STLTEEMVFSQELESTSPSKHSPPKSCLSMSKQESS 2046

  Fly   202 ------------PLRSPSFTMPSNSGAEDKVALLEAQKTS--AELQAQLADLTEKL-------ET 245
                        |::|   ..|..|.:::.:::.:::.||  ::::.::..|.::|       |.
Mouse  2047 KASHRTEGHCHLPVKS---HQPCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVEQ 2108

  Fly   246 LK-QRRNEDKERLREFDKMKI-QFEQLQEFRTKIMG---------AQASLQKELLRAKQEAKDAI 299
            || ::|...||||:..:...: |.|...||..|..|         ..:..|.:.|.:..| |..|
Mouse  2109 LKREQRKRQKERLKAQEASLLRQLETYDEFIKKTEGELSQDLDISPTSKFQMKTLSSVSE-KPKI 2172

  Fly   300 EAKEQHAQEMADLADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRS-EMQNKAE 363
            :....|..|.|....:|......:......|:.:...|..|:..|.|..:.....|. |:.::.|
Mouse  2173 KPHPLHRSETAKTWKSVTESERSRGSLASIAEHVDSSLSCSERAISERSLSAYAKRGVELDSRIE 2237

  Fly   364 SAIGNISGGGDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDK-HDIQKLSKELEMKRSEVTE 427
            ..      ...||.||:.:.:...:.::....:|..:::|:|.|: :|:.:...|...::||:.|
Mouse  2238 HL------QASSPDLSSRKAQTESRDSLESAPSLSPVKELNAPDRIYDVSEAKAEDTSQKSEIQE 2296

  Fly   428 LERTKEKLSAKIDEL---EAIVADLQEQVDAA---LGAEEMVEQLAEKKMELEDKVKLLEEEIAQ 486
            :|..|.: |:::::.   ::..:::..::|.|   |.::|:....|..:.:|:........|  :
Mouse  2297 IESMKLE-SSEVEDACCKQSGGSEVLLKLDLASETLSSKELPSDSANVQQDLDKPATETSHE--K 2358

  Fly   487 LEALEEVHEQLVESNHELELDLREELDLANGAKKEVLRERDAAI---------ETIYDRDQTIVK 542
            .|||:|     .:|||..: |...::..|.|..::..||...:.         |:.|..|..:..
Mouse  2359 EEALKE-----DQSNHSTD-DRSPDIQSAGGIPEQGCRESGDSTCSGQLSVPKESSYSEDFEVSS 2417

  Fly   543 FRELV---------------QKLNDQLTELRDRNS---SNEKESLQDPSLKMVTETIDYKQMFAE 589
            ||:.:               ..|.......|||:.   |:...:....|.:.::|.:..|.:...
Mouse  2418 FRKGISADEISKDDSEGSSPSSLRKDSQSHRDRSQLTRSSRSRATGSGSDEEISECLGEKSLSVH 2482

  Fly   590 SKAYTRAIDVQLRQ-IELSQANE-----HVQMLTAFMP--------------------------- 621
            |..::..: ::||. .||.::.|     |.|..|..:|
Mouse  2483 SGVHSERL-LELRSPTELMKSKERSDVGHEQGGTEPLPLAATEELLDFHIGDRVLIGSVQPGTLR 2546

  Fly   622 ---ESFMSRG---------------GDHDSILVILLISRI-VFKCDIVVSQTRERFPPVDAITRE 667
               |:..::|               |.:|.|:..:...:. :|.....:|...|.|...|....|
Mouse  2547 FKGETDFAKGFWAGVELDKPEGNNNGTYDGIVYFVCKDKHGIFAPPQKISHLLENFDDTDINEDE 2611

  Fly   668 AVTQGHAVQQYA--------FKC------RLLHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLP 718
               :.::.:||.        .||      .:..|.                |:        .|||
Mouse  2612 ---ESYSDEQYQPYNQEQKDIKCLKDRENNIAEYF----------------CE--------KSLP 2649

  Fly   719 EMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSV--LLAGEQLLNEIQMIRDCVAS 781
            .|...:..||      |...|  |..||..|......:...||  |::.::  |:: ::.|...|
Mouse  2650 SMHNTDASVD------KDRSL--NIETDTSEVLEVHGHQQPSVDPLISYKE--NKV-LVSDATES 2703

  Fly   782 LGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLS 846
            :.||..:..||...:....|:..|..:.....|.|.:....:...:...|.:|.:.   :||.:|
Mouse  2704 VPAAAGAATSDNTFSGESKQQQLAEKEENFYSQVLEKPSTPLLDLLTREKNQLEAQ---LKSSIS 2765

  Fly   847 QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYEQ 911
            :.|                    .:||.|..:                    :|||.|..:::.:
Mouse  2766 EEK--------------------KSKQQLETV--------------------SLLTDSLLQVFVK 2790

  Fly   912 DDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQL 976
            |.....|..|   ...|..:||..|..||              |:|......|         :..
Mouse  2791 DTVSQLQQVK---KARNEKIQLSNQEFLD--------------QKKVPPQDLP---------QNT 2829

  Fly   977 EQKN------VLAATLENREADVK--------QLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNE 1027
            |:::      .|.:.||:.:.::.        :..|.....|.||:     |.|||.::|   .|
Mouse  2830 EEQSPSVPSCFLRSELEDEKEEISSPDMCPRPESPVFGASGQEELA-----KRLAELEIS---RE 2886

  Fly  1028 YEHAVD--KW--------------KQKYEETSLQLQLKEKEFEE-------TMDHLQSDIDALES 1069
            :..|:|  .|              |.|.|||.:.|..:.|...:       .:.|...::::|..
Mouse  2887 FLSALDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRAPQKPCETLLAVPHTAEEVESLVH 2951

  Fly  1070 EKSDLRDKLKLNSTTGKVQPGSESHSPHNISLS----GNTSTAPGISNVSYSAPAGTAPVVAEEV 1130
            ..::...|.|        :.|.:.   |.:||.    |..|....|.:.|       ..|..:.|
Mouse  2952 NAAEELWKWK--------ELGQDL---HGLSLPTTFLGGASKGLDIGSTS-------RRVYKQAV 2998

  Fly  1131 -----ELLKNAFNQERNQRLRLQAQDMRAKLSQFEPLHVPQPQDQRITALESELTRMKH---AWV 1187
                 |:.:..|.::.|....:..:..|...|.|..:..|           :.|..:||   ..|
Mouse  2999 FDLTKEIFEEIFAEDPNVNQPVWMKPCRINSSYFRRVKNP-----------NNLDEIKHFITTEV 3052

  Fly  1188 LSLLQVRSQDSVNSG------------TRIDAVALQRRNQ 1215
            |.||.::.:.:..:.            .|:|.:.:|..::
Mouse  3053 LKLLSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHE 3092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	61/351 (17%)
Cep350	XP_006529963.1	PTZ00121	<1336..>1814	CDD:173412
		PTZ00108	<1890..2151	CDD:240271	50/236 (21%)
		COG5022	<2095..2375	CDD:227355	64/295 (22%)
		NIP100	2531..>2808	CDD:227569	60/360 (17%)
		CAP_GLY	2531..2595	CDD:366568	6/63 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900