DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and CLIP1

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001376220.1	Gene:	CLIP1 / 6249	HGNCID:	10461	Length:	2148	Species:	Homo sapiens

Alignment Length:	1575	Identity:	339/1575 - (21%)
Similarity:	589/1575 - (37%)	Gaps:	458/1575 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMF 67
            |:.||:|.|| |.|....|.|.::|.|.||.|:|.||.||||.|||.|::.|.:||||....|:|
Human   209 ERELKIGDRV-LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLF 272

  Fly    68 V---RPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLG--SRTQLTT 127
            .   :.|::......|...::.........|:|...::..:||.:|:||...|:..  |||.|.|
Human   273 APVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLT 337

  Fly   128 SLSERTAS--SSSIGPRKSLAPQNSKDKESPSTSL--------AEGAPAAS-----------GGN 171
            ..|.|.|.  |.:...:::|     |:|:.....|        ||.|.|.|           ..:
Human   338 ETSSRYARKISGTTALQEAL-----KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397

  Fly   172 GAASHASSKRA------SFVETG---FLEILKPQFTPSQPLRSPSFTMPSNS---------GAED 218
            |...|.....|      :.||..   .:|:|.......:.:....|.:...|         ...:
Human   398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462

  Fly   219 KVALLEAQKTSAELQAQLADLTEKLETLKQRRNED------------KERL--------REFDKM 263
            |..::|.:|..|....::|:|..:||:.|...:.|            :|:|        ||...:
Human   463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 527

  Fly   264 KIQFEQLQEFRTKIMGA-----------QASLQKELLRAKQEAKDAIE----------AKEQHAQ 307
            |..|...:|...|.:.|           ..||:.:|..|.:|..|.|.          |..|.|.
Human   528 KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 592

  Fly   308 ----------------EMADLADNVEMITLD--------------------KEM----------A 326
                            |.|:|...:|.:.||                    |||          .
Human   593 EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 657

  Fly   327 EEKADTLQ--------------LELESSKERIEELEV---DLELLRSEMQNKAESAIGNISGGGD 374
            :||.::|:              :|:|.:..:::|.|:   :||:|:::. |:....|.|.
Human   658 KEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC-NEQTKVIDNF----- 716

  Fly   375 SPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKI 439
                 |.:.|..|::.:.|.    .||..|:..|.:::||.::||....::..||..|...|:|
Human   717 -----TSQLKATEEKLLDLD----ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK- 771

  Fly   440 DELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEV------HEQLV 498
              ..:|..:||.:.......:|.:.::::.|..||.::::|:|:.|  ||.||.      .::.|
Human   772 --ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA--EASEEAVSVQRSMQETV 832

  Fly   499 ESNHELELDLREELDLANGAKKEVLRERDAAIETIY----DRDQTIVKFRELVQ----------- 548
            ...|:.|    |:.::.: :..|.|||..|.:|..:    :|::.::|.:|.::
Human   833 NKLHQKE----EQFNMLS-SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 892

  Fly   549 -------KLNDQLTELRDRN---------SSNEKESLQDPSLKMVTETIDYKQMFAESK--AYTR 595
                   |:||:| .|::|:         .:||..|....|::.:|...:..|..|..|  ...:
Human   893 DNSSQLTKMNDEL-RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956

  Fly   596 AIDVQLRQIELSQANEH--VQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVVSQTRERF 658
            .::.:|..:|......|  .|.|.|....:.......|:.||..|  .:.:...:..:...||.
Human   957 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNL--QKTLLDTEDKLKGAREE- 1018

  Fly   659 PPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQI------LYGLNSCQP-------DTL 710
                  ....:.:...:::.|.|.:.|.|:  |..|..:|      |.||.|.:.       |..
Human  1019 ------NSGLLQELEELRKQADKAKSLTYL--LTSAKKEIELMSEELRGLKSEKQLLSQEGNDLK 1075

  Fly   711 LRAGSSLPEMVAQEKIVDGIIELLKSNQ--LDENSTTDNIEK---------CVAFFNA--MNSVL 762
            |..||.|.::|.    ::..|.||:.:|  |...:.|.|:||         ...::..  :|...
Human  1076 LENGSLLSKLVE----LEAKIALLQGDQQKLWSVNETLNLEKEKFLEEKQDAEKYYEQEHLNKEA 1136

  Fly   763 LA--GEQLLNEIQMIRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVL-------------- 811
            ||  .|:||.||.::::.:..:....:|:.:.....:.:|:|...:.|:::
Human  1137 LAVEREKLLKEINVVQEELLKINVENDSLQASKVSMQALIEELQLSKDTLIAKTEKDQEEKDHLE 1201

  Fly   812 --LIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLSQHKVEAMRGLAQNISRI----MSAMHQA 870
              :.:.:.||....:.:..:|::...|.:.::|.         .:.|.|....:    .||:.:.
Human  1202 DQIKKLITENFILAKDKDDIIQKLQRSYEELVKD---------QKALVQETEDLTAEKKSALEKL 1257

  Fly   871 TKQSLAAIVSTIESDNAAEHT-----------LPQEKYWALLTASCERIYEQDDRGPTQNFKTLL 924
            :......|...:|.||..::.           ..|||..|.|.|:.:             .|.||
Human  1258 SNLDNTCIALKVERDNVLQNNRNLQLETDMLLQDQEKLNASLQAALQ-------------VKQLL 1309

  Fly   925 AQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQ-----------LEQ 978
            ....|.|:  ||  ||.....:..|...:.|.:  |.:|.:|:..:.||.:           |.:
Human  1310 RSEASGLR--AQ--LDDASKALRKAELETVQLE--AANTSLTKLLEEIKARRAVTDSECIQLLHE 1368

  Fly   979 KNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAE---------KKLSVLQNEYEHAVDK 1034
            |..|||:.....|:.::|     :.:|.:...::.|.|.|         :|::.|.:|.|.|..|
Human  1369 KETLAASERRLLAEKEEL-----LSENRIITEKLHKCLEEAAHTEMSLNEKITYLTSEKEMASQK 1428

  Fly  1035 WKQ-KYEETSLQLQLKEKEFEETMD------------------------------------HLQS 1062
            ..: |.::.||   ||||...||.:                                    .|..
Human  1429 MTELKKQQDSL---LKEKSSLETQNGALLAERENSIKAIGDLKRQCDQESANRSLVVQENMKLLG 1490

  Fly  1063 DIDALESE--------------KSDLRDKLKLNSTTGKVQPGSESHSPHNI----SLSGNTSTAP 1109
            :||||:.|              |.||...||....|.|   ..|....|.:    ||....:|..
Human  1491 NIDALKKELQERKKENQELVASKCDLSLMLKEAQNTKK---NLEKEHTHILQAKESLDAQLNTCC 1552

  Fly  1110 GISNVSYSAPAGTAPVVAEEVELLKNAFN------------QERNQRLRLQAQDMRAKLSQFEPL 1162
            ...|:                 ||::..|            ||..|.|.|: |:.|||.|: ..|
Human  1553 SEKNI-----------------LLRDGLNLQEECHKLSKEIQEMQQSLILE-QEARAKESE-SSL 1598

  Fly  1163 HVPQPQDQRITALESELTRMK------HAWVLSLLQVRSQDSVNSGTRIDAVALQRRNQPVPLKG 1221
            :.......|:..||.|:..::      .:....|||.:|:..            |...:.:..|.
Human  1599 YENNQLHGRMVLLEQEVEELRVCIEELQSEKFVLLQEKSKSE------------QELAEIIEEKE 1651

  Fly  1222 EISSKASQLASDILT 1236
            .::::|:|||:.|.|
Human  1652 LLTAEAAQLAAHIKT 1666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	31/68 (46%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	64/337 (19%)
CLIP1	NP_001376220.1	CAP_GLY	60..124	CDD:396049
		CAP_GLY	214..278	CDD:396049	30/64 (47%)
		SbcC	<335..835	CDD:223496	107/524 (20%)
		Smc	612..1442	CDD:224117	184/906 (20%)
		Smc	1176..1977	CDD:224117	113/561 (20%)
		CLIP1_ZNF	2126..2142	CDD:406934
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840