Protein Alignment DCTN1-p150 and dctn1

DIOPT Version :9

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_012811215.1
• Gene: dctn1 / 447948
• XenbaseID: XB-GENE-5933522
• Length: 1296
• Species: Xenopus tropicalis
• Alignment Length: 1297
• Identity: 455/1297 - (35%)
• Similarity: 708/1297 - (54%)
• Gaps: 131/1297 - (10%)

  Fly     4 KNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFV 68
            |.||||:|||:.||...|||||||.|.||.||||||:||:.||||.|:::|::||.|:||.|:||
 Frog    41 KPLKVGSRVEVIGKGYRGTVAYVGATLFATGKWVGVILDDSKGKNDGTVQGRRYFTCEENHGIFV 105

  Fly    69 RPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSERT 133
            |.:|::::|            .||..|:.:..:...|..                 |...:||..
 Frog   106 RQSQIQVIE------------DGADTTSPETPEPAASKG-----------------LKKDVSETP 141

  Fly   134 ASSSSIGPRKSLAPQNSK------DKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEI 192
            .||...|.:...||...|      ....||:|.|....|.:.|:.:||           .|.:..
 Frog   142 KSSKLRGVKPKKAPTTRKITTRRTKPTRPSSSAASSGTAGASGSASAS-----------CGEISS 195

  Fly   193 LKPQFTPSQ-PLRSPSFTMPSNSGAEDKVALLEA---QKTSAELQAQLADLTEKLETLKQRRNED 253
            .:|. ||:| ||.:|....|| |.....||.|..   .|....|:||:.||.|||||||.:|.||
 Frog   196 SEPS-TPAQTPLAAPIIPSPS-SAILSPVAPLPGPGPTKEEENLRAQVKDLDEKLETLKMKRAED 258

  Fly   254 KERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEM 318
            |.:|:|.:|.|:|.|||||:::|:...||.:|::|..||:|||:|:||||::.:||||.||.:||
 Frog   259 KAKLKELEKSKLQLEQLQEWKSKMQEQQADVQRQLKEAKKEAKEALEAKERYMEEMADTADAIEM 323

  Fly   319 ITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEF 383
            .|||||||||:|::||.|:::.|:::|||::|||:.:.|::.|           |.....|:|:.
 Frog   324 ATLDKEMAEERAESLQQEVDTLKDKVEELKIDLEIFKHEIEEK-----------GSDGAASSYQV 377

  Fly   384 KQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVAD 448
            ||||:||.||||.|||:|||||.:|.:..|:.|::|.|.:|:..|.:.||||..:...:|..:.:
 Frog   378 KQLEEQNARLKEALVRMRDLSASEKQEHVKVQKQMEKKNTELDTLRQQKEKLQEEASLMEKTIDE 442

  Fly   449 LQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELD 513
            |:||||||||||||||.|.|:.::||:||:.|.|.::.|||:.|::::|.|:..|.||:|||:||
 Frog   443 LKEQVDAALGAEEMVETLTERNLDLEEKVRELRETVSDLEAINEMNDELQENARETELELREQLD 507

  Fly   514 LANGAKKEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRD-RNSSNEKESLQDPSLKMV 577
            :|....:|..:..:||.||:.|..|||.|:|:|...|.:...|||: :.:|.|||  |.||
 Frog   508 MAGARVREAEKRVEAAQETVADYQQTIKKYRDLTAHLQEVNRELRNQQEASVEKE--QQPS---- 566

  Fly   578 TETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISR 642
            .|..|:|..|||:||:.:||:::||::|:||||.||.:||:|||:||:..|||||.|||:|||.|
 Frog   567 PEMFDFKIKFAETKAHAKAIEMELRKMEVSQANRHVSLLTSFMPDSFLRHGGDHDCILVLLLIPR 631

  Fly   643 IVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQP 707
            ::.|.:::..|.:|:|...:|..:::..:|...:|.:|...|::.:..||..||:....|:.|..
 Frog   632 LICKAELISKQAQEKFELSEASEQKSGMRGAVGEQMSFAAGLVYSLTLLQATLHKYEQALDKCSV 696

  Fly   708 DTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGE------ 766
            :...:.|...|||...|:.:|.:||||..:||||....:.:.|.:.::..:.|:.||.:
 Frog   697 EVYKKVGMLYPEMSVHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLADQSEECTM 761

  Fly   767 QLLNEIQMIRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIK 831
            ||.:.|:..:..:..:|.       :.:..:..:.....:||..:|::.|..:...:||..|.|:
 Frog   762 QLSDHIKFTQSALDCMGV-------EVSRLRAFLHVGQESSDFAILLKDLETSCSDIRQFCKKIR 819

  Fly   832 RRLPSDQHVIKSGLSQHKVEAMRGLAQNISRIMSAMHQATK------QSLAAIVSTIESDNAAEH 890
            ||:|        |.....:.|....||.:...:....:..|      |.:||..:.:.:......
 Frog   820 RRMP--------GTEAAGIPAALSFAQPVCETLLDCRKYLKCVVAVFQEVAAAGAQMIAPMGENE 876

  Fly   891 TLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQ 955
            .|...|...:...:.|:||......|.:..:...:...:.:..:|..:.:.|||.      ...|
 Frog   877 GLQALKLEDVAFKATEQIYGSKGSNPYECLRQSCSVVIATMNKMATAMQEGEYDA------EKPQ 935

  Fly   956 QKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKK 1020
            .||   ..|:.|||..::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.|||
 Frog   936 SKS---PPPVEQRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKK 997

  Fly  1021 LSVLQNEYEHAVDKWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTG 1085
            |.....|.:..|:|.:.|.|||...|:.||||||||||.||:|||.|||||::||.:|. |.:..
 Frog   998 LDSASKEADDRVEKIQTKLEETQTVLKKKEKEFEETMDALQADIDQLESEKAELRQRLN-NQSKR 1061

  Fly  1086 KVQ--PGSESHSPHNI--SLSG-----NTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQER 1141
            .::  .||.:....:|  .|:|     ..|:...:.|.|.......:|::.::::.|:.:....:
 Frog  1062 TIEGLRGSPASGVASIVSGLAGEEEQRGVSSGQSLLNGSGPVQVKDSPLLLQQIDALRLSMKHLK 1126

  Fly  1142 NQRLRLQAQDMRAKLSQFEPLHVPQ---PQD-QRITALESELTRMKHAWVLSLLQVRSQDSVNSG 1202
            ::..:|:|..::|.|:....||||:   |:| ||..||...|.| |.:.:|..||   |.|.|:.
 Frog  1127 HENNKLKAHQIKADLASLPALHVPKLSLPKDRQREEALSGTLYR-KTSQLLDALQ---QMSANAK 1187

  Fly  1203 T------RIDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPTVD 1258
            .      :..:.|:....|...|| .:|....:|..:::.|.:.:.|.......||:||:.|
 Frog  1188 VVDIAHKKAGSPAVHLLEQTARLK-SLSDTIDKLKDEVMKETVAQCPGANVPTDFATFPSSD 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	41/65 (63%)
		Dynactin	553..834	CDD:289240	94/287 (33%)
dctn1	XP_012811215.1	CAP_GLY	45..111	CDD:214997	41/65 (63%)
		DUF4200	313..432	CDD:290574	62/129 (48%)
		Lebercilin	360..535	CDD:292252	81/185 (44%)
		Dynactin	539..822	CDD:289240	96/295 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1258
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3011
Inparanoid	1	1.050	679	1.000	Inparanoid score	I712
OMA	1	1.010	-	-		QHG53055
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0005456
OrthoInspector	1	1.000	-	-		otm48450
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080