Protein Alignment DCTN1-p150 and dctn1a

DIOPT Version :10

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_073762475.1
• Gene: dctn1a / 407638
• ZFINID: ZDB-GENE-070117-2205
• Length: 1250
• Species: Danio rerio
• Alignment Length: 1304
• Identity: 445/1304 - (34%)
• Similarity: 705/1304 - (54%)
• Gaps: 150/1304 - (11%)

  Fly     6 LKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFVRP 70
            :|||:.||:.||...|||||:|.|.||.||||||:|||.||||.|:::|::||.|:||.|:|||.
Zfish    10 VKVGSVVEVIGKGQRGTVAYIGATLFASGKWVGVILDEAKGKNDGTVQGKRYFTCEENHGIFVRQ 74

  Fly    71 TQLRLLEAAPGSRRSIEDV-SGA----------TPTAAQPTKA------RLSS-----SRTSLSS 113
            :|::|::....|..|.|.. ||.          ||..|:.|.|      |.|:     .|.|.||
Zfish    75 SQIQLMDDGGSSATSPETPDSGVAKLLKKEIQETPKTAKQTPAVKKPPVRRSTKWSTPGRLSTSS 139

  Fly   114 SRQSLL--GSRTQLTTSLSERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASH 176
            |..||:  |..:...::|||...:.|               :.|.||.::..||.....:.|::.
Zfish   140 SLPSLIMTGRPSVGGSALSESVLAES---------------ESSSSTQMSLAAPVVPQPSTASTP 189

  Fly   177 ASSKRASFVETGFLEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTE 241
            |.:                  |||                          |....|:|||.||.|
Zfish   190 APA------------------TPS--------------------------KEEESLRAQLKDLEE 210

  Fly   242 KLETLKQRRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHA 306
            |||||:.:|:|||.:|:|.:|.|||.|||||:|:|:...|..|||:|..||:||::|:|||:::.
Zfish   211 KLETLRMKRSEDKAKLKEMEKYKIQLEQLQEWRSKMQEQQNDLQKQLKEAKKEAREALEAKDRYM 275

  Fly   307 QEMADLADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISG 371
            :||||.||.:||.|||||||||:|::||.|.||.||::|||.:|:|:|:.|::.|
Zfish   276 EEMADTADAIEMATLDKEMAEERAESLQQETESLKEKLEELTMDMEILKHEIEEK---------- 330

  Fly   372 GGDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLS 436
             |.....|:|..||||:||.||||.|||:||||:.:|.:..||.|::|.|.||:..|...||||.
Zfish   331 -GSDGAASSYHVKQLEEQNARLKEALVRMRDLSSSEKQEHVKLQKQMEKKNSELETLRSQKEKLQ 394

  Fly   437 AKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESN 501
            .::...|..:.:|:||||||||||||||.|.|:.::||:||:.|.|.::.||::.|::::|.|:.
Zfish   395 EEMKLAEDTIDELKEQVDAALGAEEMVETLTERNLDLEEKVRELRETVSDLESINEMNDELQENA 459

  Fly   502 HELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEK 566
            .|.||:|||:||||....:|..:..:||.||:.|..|||.|:|||...|.:...||.::.||: .
Zfish   460 RETELELREQLDLAGARVREAQKRVEAAQETLADYQQTINKYRELTTHLQEVNRELTNQQSSS-A 523

  Fly   567 ESLQDPSLKMVTETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDH 631
            |.||.|:    .|..|:|..|||:|||.:||:::||::|:||||..|.:||:||||||:..||||
Zfish   524 EQLQQPA----AELFDFKIKFAETKAYAKAIEMELRKMEVSQANRQVSLLTSFMPESFLRHGGDH 584

  Fly   632 DSILVILLISRIVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALH 696
            |.|||:|||.|::.|.:::..|.:|:|.........|..:|.|.:|.:|...|::.:..||..||
Zfish   585 DCILVLLLIPRLICKAELISKQAQEKFDLTGGSLERAGLRGAAGEQLSFASGLVYSLTLLQATLH 649

  Fly   697 QILYGLNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSV 761
            :....|:.|..|...|.|....||...|:.:|.:|:||..:||||....:.:.|.:.::..:.||
Zfish   650 KYELALSVCGVDVYKRMGMLYSEMCVHERSLDFLIDLLHKDQLDETVQVEPLTKAIKYYQHLYSV 714

  Fly   762 LLAGE------QLLNEIQMIRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENM 820
            .|..:      ||.:.|:..:..:..:|       |:....:..:|.....::..:|::.|:.:.
Zfish   715 HLCDQPEDCTVQLADHIKFTQSALDCMG-------SEVGRLRAFLQAGQEGAELCVLLKDLDTSC 772

  Fly   821 ESVRQQVKLIKRRLP-SDQHVIKSGL--SQHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTI 882
            ..:||..|.|:||:| :|...|.:.|  |:...||:....:.::|:::.:.:.:......:....
Zfish   773 GDIRQFCKKIRRRMPGTDAPGIPAALRFSEQVSEALADSRKQLARVVAVLQEVSAAGAQMMAPLQ 837

  Fly   883 ESDNAAEHTLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIIS 947
            |.:..:...:....:.|:     |::|......|.:..:...:...:.:..:|..:.:.|||
Zfish   838 EQEGLSAVKIEDVAFKAV-----EQVYGTQGLNPYECLRQSCSAVIATMNKMATAMQEGEYD--- 894

  Fly   948 AANNASNQQKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQI 1012
                   .::......|:..||..::.::.....|...||:||..:|:||.:.|:|..||||..:
Zfish   895 -------SERPQRPPPPVETRAAAVRAEMTDAEGLGNKLEDRETVIKELKKSLKIKGEELSEANV 952

  Fly  1013 RKDLAEKKLSVLQNEYEHAVDKWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDK 1077
            |..|.||||.....:.:..|:|.:.|.:|....|:.||||||||||.||:|||.|||||::|:.:
Zfish   953 RLSLLEKKLDTSTKDADERVEKIQTKLDEALNTLKKKEKEFEETMDALQADIDQLESEKAELKQR 1017

  Fly  1078 LKLNS--TTG-KVQPGSESHSPHNISLSGNTSTAP-GISNVSYSAPAGTAPVVAEEVELLKNAFN 1138
            :...|  |.| :.||.|...|....:::|...:|| |:|.|   .....:|::.:::::.:.|..
Zfish  1018 ISSQSRATEGLRGQPASGIASIVTGNVAGGMLSAPAGVSGV---VQVVDSPLLKQQIDVQRIAIK 1079

  Fly  1139 QERNQRLRLQAQDMRAKLSQFEPLHVP------QPQDQRITALESELTRMKHAWVLSLLQVRSQD 1197
            |.:::..||:|:.|||:||...||.||      ..::....||:.:...:.|    :|:::.:..
Zfish  1080 QLKSENYRLKAERMRAQLSSLPPLQVPNMKSVMMKENTAAGALQRKTDVLLH----NLMKMSAGL 1140

  Fly  1198 SV--NSGTRIDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPTVDVK 1260
            .|  .:|....:.:.|...|...:| .:|....:|.:::....:.::|..:....||:|||....
Zfish  1141 KVVDITGKTTASASAQLLEQTAKMK-SLSDALDKLQAEVSQHVVSQQPGASVPSDFATFPTATFV 1204

  Fly  1261 RVLQ 1264
            :..|
Zfish  1205 KAQQ 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..73	CDD:460154	39/64 (61%)
		NIP100	13..>272	CDD:227569	98/282 (35%)
		SMC_prok_B	<219..>497	CDD:274008	136/277 (49%)
		Dynactin	550..834	CDD:463591	95/289 (33%)
		Smc	<965..>1080	CDD:440809	48/114 (42%)
dctn1a	XP_073762475.1	None