DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and Clip2

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_068837.2	Gene:	Clip2 / 29264	RGDID:	62019	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	225/966 - (23%)
Similarity:	391/966 - (40%)	Gaps:	239/966 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMF 67
            :|:|.:|.|| |.|....|.|.|||.|.||.|:|.||.||||.|||.|::.|.:||||....|:|
  Rat   217 DKDLHLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLF 280

  Fly    68 VRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSER 132
            . |....:....|.:          :|..|:.|| |::...::|:.|..|         :|:|..
  Rat   281 A-PIHKVIRIGFPST----------SPAKAKKTK-RMAMGVSALTHSPSS---------SSISSV 324

  Fly   133 TASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVE--TGFLEILK- 194
            ::.:||:|.|             ||.|            |..:..||:.|..:.  |...|.||
  Rat   325 SSVASSVGGR-------------PSRS------------GLLTETSSRYARKISGTTALQEALKE 364

  Fly   195 -----PQFTPSQPLRSPSFTMPSN--SGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNE 252
                 .|....:.|........::  ...|.::|||:||.     :..:|:..|||    ||...
  Rat   365 KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH-----EQYVAEAEEKL----QRARL 420

  Fly   253 DKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVE 317
            ..|.:|: :|:.:. .||:|.|.|:...|..:::|.:     .|..:|.:.|  .|.|.:.:..:
  Rat   421 LVENVRK-EKVDLS-NQLEEERRKVEDLQFRVEEESI-----TKGDLETQTQ--LEHARIGELEQ 476

  Fly   318 MITLDKEMAE----EKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGL 378
            .:.|:|..||    |.||. :|...:.|.|:.:||.:|.|.|.|::......:.:.....|.|..
  Rat   477 SLLLEKAQAERLLRELADN-RLTTVAEKSRVLQLEEELSLRRGEIEELQHCLLQSGPPPADHPEA 540

  Fly   379 STYEFKQLEQQNIRLKETLVRLRDLSAHDKHD-----IQ-KLSKELEMKRSEVTELERTKEKLSA 437
            :         :.:||:|.|     |||..:|.     :| |....|:..::||.:|....||.:.
  Rat   541 A---------ETLRLRERL-----LSASKEHQRDSTLLQDKYEHMLKTYQTEVDKLRAANEKYAQ 591

  Fly   438 KIDELEAIVADLQEQVDAALGA----EEMVEQLA-EKKMELEDKVKLL-------EEEIAQLEAL 490
            ::.:|:|.|   |:.....:|.    :..::.|| :.:..|||....|       ::||.:|:||
  Rat   592 EVADLKAKV---QQATTENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAL 653

  Fly   491 EEVHEQLVESNHELEL-DLREELDL---ANGAKKEVLRERDAAIETIYDRDQTIVKFRELVQKLN 551
            .|.    ::..|:||| :|:.:.||   .:|.:||.||::                    :|:..
  Rat   654 VEG----IKMEHQLELGNLQAKHDLETAMHGKEKEGLRQK--------------------LQEAQ 694

  Fly   552 DQL--------TELRDRNSSN--EKESLQDPSLKMVTETIDYKQMFAESKAYTRAIDVQLRQIEL 606
            ::|        .:|.::.|.:  |.:..||..........:.:.:..|.:...:||:....||.|
  Rat   695 EELAGLQQHWRAQLEEQASQHRLELQEAQDQCRDAQLRVQELEGLDVEYRGQAQAIEFLKEQISL 759

  Fly   607 SQANE-HVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVVSQTRERFPPVDAITREAVT 670
            ::... ..:||.....:|........:.:||                 ...|...|:::.  :..
  Rat   760 AEKKMLDYEMLQRAEAQSRQEAERLREKLLV-----------------AENRLQAVESLC--SAQ 805

  Fly   671 QGHAVQQYAF---KCRLLHYVHSLQCALH---QILYGLNSCQPDTLLRAGSSLPEMVAQ--EKIV 727
            ..|.::....   |.|:...|..||..|:   :.:..|.| |.| :|||..|..|...:  ||.:
  Rat   806 HSHVIESNDLSEEKIRMKETVEGLQDKLNKRDKEVAALTS-QMD-MLRAQVSALENKCKSGEKKI 868

  Fly   728 DGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMI------------RDCVA 780
            |.:::..:..:.:..:.:............::..||..|:.|||::::            ||
  Rat   869 DSLLKEKRRLEAELEAVSRKTHDASGQLVHISQELLRKERSLNELRVLLLEANRHSPGPERD--- 930

  Fly   781 SLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKL---------------- 829
                    :..:...|:..|:|.....|    |:.|.|.:..:.::..|
  Rat   931 --------LSREVHKAEWRIKEQKLKDD----IRGLREKLTGLDKEKSLSEQKRYSLIDPASAPE 983

  Fly   830 ---IKRRLPSDQHVIKSGLSQHK-----VEAMRGLA---QNISRIMSA--MHQATK 872
               ::.:|.|.:..::..|.|.:     |||:||.:   |.||...||  :||..|
  Rat   984 LLRLQHQLVSTEDALRDALDQAQQVERLVEALRGCSDRTQTISNSGSANGIHQPDK 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	33/65 (51%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	54/330 (16%)
Clip2	NP_068837.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		CAP_GLY	82..146	CDD:396049
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..216
		CAP_GLY	222..286	CDD:396049	33/65 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..340		11/59 (19%)
		Smc	<357..1016	CDD:224117	157/754 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1047		8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810