DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and Dctn1

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_077044.2	Gene:	Dctn1 / 29167	RGDID:	62038	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1281	Identity:	432/1281 - (33%)
Similarity:	690/1281 - (53%)	Gaps:	98/1281 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
  Rat    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87

  Fly    67 FVRPTQLRLLE-AAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLS 130
            |||.:|:::.| .|..:.....|.|.:.....:...|...:|:......:::....:|.......
  Rat    88 FVRQSQIQVFEDGADTTSPETPDSSASKILKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKP 152

  Fly   131 ERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195
            .|.||:...||..||.|..|                ||.|..::|..|
  Rat   153 TRPASTGVAGPSSSLGPSGS----------------ASAGELSSSEPS----------------- 184

  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259
              ||:| ||.:|....|:.:.......|....|....|:||:.||.||||||:.:|:|||.:|:|
  Rat   185 --TPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKE 247

  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
  Rat   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312

  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
  Rat   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366

  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
  Rat   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431

  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
  Rat   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496

  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
  Rat   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556

  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
  Rat   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621

  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
  Rat   622 IRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686

  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||.......:.|.:
  Rat   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEESTMQLADHI 750

  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843
            ....:|.:.:..:....:..:|.....:|..||::.|..:...:||..|.|:||:| :|...|.:
  Rat   751 KFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPA 815

  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906
            .|:  ....:.:....::::.:::.:     |.:||..:.:.:..|....||......|...:.|
  Rat   816 ALAFGSQVSDTLLDCRKHLTWVVAVL-----QEVAAAAAQLIAPLAENEGLPVAALEELAFKASE 875

  Fly   907 RIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQL 971
            :||......|.:..:...:...|.:..:|..:.:.|||          .::..:...|:..||..
  Rat   876 QIYGSPSSSPYECLRQSCSILISTMNKLATAMQEGEYD----------AERPPSKPPPVELRAAA 930

  Fly   972 IKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWK 1036
            ::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::|.:
  Rat   931 LRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQ 995

  Fly  1037 QKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNISL 1101
            .:.|||...|:.||||||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..|:.
  Rat   996 TRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKTEL--KQRLNSQSKRTIEGLRGPPPSGIAT 1058

  Fly  1102 ------------SGNTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMRA 1154
                        .|....|||.  :....|...:|::.:::..::...:|.:::...|:...|:|
  Rat  1059 LVSGIAGEEQQRGGTPGQAPGA--LPGPGPVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKA 1121

  Fly  1155 KLSQFEPLHV-----PQPQDQRITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVA----L 1210
            .|:...||||     |..:......|...|.|.....:..|.|:.:...|...||....|    .
  Rat  1122 SLAALPPLHVAKFSLPPHEGPGGNLLSGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSA 1186

  Fly  1211 QRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256
            |...|...|| .:|....:|..::|.|.:.::|.......||:||:
  Rat  1187 QLMEQVAQLK-SLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPS 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	42/65 (65%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	91/280 (33%)
Dctn1	NP_077044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/2 (50%)
		CAP_GLY	29..94	CDD:396049	41/64 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..223		30/158 (19%)
		Herpes_BLLF1	<101..>214	CDD:282904	28/147 (19%)
		SMC_prok_B	220..>540	CDD:274008	155/330 (47%)
		Dynactin	527..805	CDD:403600	93/283 (33%)
		Interaction with HPS6. /evidence=ECO:0000250\|UniProtKB:O08788	911..1281		96/336 (29%)
		SMC_prok_A	<924..>1037	CDD:274009	48/114 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1090		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342641
Domainoid	1	1.000	302	1.000	Domainoid score	I1357
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3011
Inparanoid	1	1.050	664	1.000	Inparanoid score	I721
OMA	1	1.010	-	-		QHG53055
OrthoDB	1	1.010	-	-		D1550378at2759
OrthoFinder	1	1.000	-	-		FOG0005456
OrthoInspector	1	1.000	-	-		oto98494
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810