DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCTN1-p150 and CLIP3

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_001186499.1	Gene:	CLIP3 / 25999	HGNCID:	24314	Length:	547	Species:	Homo sapiens

Alignment Length:	268	Identity:	71/268 - (26%)
Similarity:	111/268 - (41%)	Gaps:	70/268 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCG 65
            :|...|::|.||.|.|:. .||:.:.|.|.||.|:||||.||||:|||.||:.|.:||.|....|
Human   289 LSALGLRLGDRVLLDGQK-TGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQG 352

  Fly    66 MFVRPTQL-RLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTT-- 127
            :|...::: :.::|.|.|            ..:.|...|:..||.:....|:.....:|..:.
Human   353 LFASVSKISKAVDAPPSS------------VTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSL 405

  Fly   128 -SLSERTASSSSIGPRKSLAPQN-------SKDKESPS----------TSLAEG----------- 163
             ||.:|..:.:.:|.:..:|.|.       .|...:|.          |...:|
Human   406 GSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCP 470

  Fly   164 ------APAAS----GGNGAASHASSKRASFVETGFLEILKPQFTPSQPLRSPSFT---MPSNSG 215
                  |||:.    ||: ..|...|..|..|.         |.|.:||.|  :||   .|.:..
Human   471 PRHGVFAPASRIQRIGGS-TDSPGDSVGAKKVH---------QVTMTQPKR--TFTTVRTPKDIA 523

  Fly   216 AEDKVALL 223
            :|:.::.|
Human   524 SENSISRL 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	31/66 (47%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240
CLIP3	NP_001186499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		ANK 1	117..158
		ANK repeat	120..157	CDD:293786
		Ank_2	122..228	CDD:372319
		ANK repeat	159..190	CDD:293786
		ANK 2	160..191
		ANK 3	197..229
		ANK repeat	198..228	CDD:293786
		CAP_GLY	296..360	CDD:366568	31/64 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..413		12/59 (20%)
		CAP_GLY	418..482	CDD:366568	10/63 (16%)
		GoLD	488..547		14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840