DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and tip1

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_593613.1	Gene:	tip1 / 2543044	PomBaseID:	SPAC3C7.12	Length:	461	Species:	Schizosaccharomyces pombe

Alignment Length:	524	Identity:	126/524 - (24%)
Similarity:	210/524 - (40%)	Gaps:	118/524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VGARVE-LTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPK----GKNSGSIKGQQYFQC--DENCG 65
            :|:.|| :||:  .|.|.|.|......|.:||:.| .|:    |||.|.:.|::||:.  :|..|
pombe     4 LGSVVEVITGE--RGFVRYAGEVENRKGVYVGLEL-LPEFAEFGKNRGVVDGREYFKTKNNEKTG 65

  Fly    66 MFVRPTQLRL---LEAAPGSRRSIEDVSGATPTAAQPTKARLSSS---RTSLSSSRQSLLGSRTQ 124
            :||...:.:|   :.::|..:  |:..:.:......|....|.||   .|::|||
pombe    66 IFVPFDKCKLASSISSSPSPK--IDGTAASIGMGFPPMSPNLQSSIPRLTNVSSS---------- 118

  Fly   125 LTTSLSERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGF 189
              ::||..|.||:::.|.:.:..:..:|      .|.|          ..:|.............
pombe   119 --SNLSMNTISSTALTPTEKILQKRIED------LLYE----------RQNHQQQLEEVLATVDQ 165

  Fly   190 LEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDK 254
            |:.|...|...|                |:|..|..:            :|.|.|.::|.|||..
pombe   166 LQSLVTNFNDQQ----------------DEVDELRER------------ITLKEERIQQMRNEAS 202

  Fly   255 ERLREFDKMKIQFEQLQE--------FRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMAD 311
            :|..||   |...|.|:|        :..:|  |:...|.|:..:.:...|.:.:.:|.    .|
pombe   203 QRRFEF---KTTIECLEESSNRAIETYENRI--AELEAQLEMYMSGKSEDDLLFSLQQE----RD 258

  Fly   312 LADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSP 376
            .|.|      ..|:.:|:.|||..:..:|....|:|. .:|.....:.|.:..:.....|..|.|
pombe   259 YALN------QVEILQERVDTLMKQKANSSTANEKLS-HMESSSPTLTNASFESPKRGKGSNDLP 316

  Fly   377 -----GLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLS 436
                 ...|.||.::|.:.:|  |.:.:|:.||......|.||.|.|:  |::.|.:. :.||||
pombe   317 ENHPQRRQTLEFYEIEIEVLR--EKVEKLQALSDEKDFYISKLEKSLD--RNDTTPVP-SDEKLS 376

  Fly   437 AKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESN 501
            ....|.|.:|:.:.|       .|..:|||........:::...|.|   ||..:||.|...:|:
pombe   377 NYAAEKENLVSRISE-------LEHTIEQLTINNERDNERMSPAEFE---LETTQEVEENDSDSH 431

  Fly   502 HELE 505
            .:.|
pombe   432 DDEE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	25/72 (35%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240
tip1	NP_593613.1	CAP_GLY	4..74	CDD:214997	25/72 (35%)
		FliE	101..>187	CDD:298840	24/141 (17%)
		BBP1_C	<140..238	CDD:291921	28/146 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18916
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030