Protein Alignment DCTN1-p150 and clip-1

DIOPT Version :10

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: NP_001022682.1
• Gene: clip-1 / 176307
• WormBaseID: WBGene00010796
• Length: 937
• Species: Caenorhabditis elegans
• Alignment Length: 801
• Identity: 154/801 - (19%)
• Similarity: 280/801 - (34%)
• Gaps: 252/801 - (31%)

  Fly     8 VGARVEL--TGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFV-- 68
            :|..|::  .||   |.:.|||......|.:.|:.|.||.||:.|:.:|..||......|:|.
 Worm    21 IGRLVDVVNVGK---GFLRYVGPIHGKDGMFCGIELLEPNGKHDGTFQGVSYFIATPYHGIFAPI 82

  Fly    69 ----------------RPTQ---------LRLLEAAPGSRRSIED-------VSGATPTAAQPTK 101
                            .|:.         |:|.......|:..||       ||.:|...|.|||
 Worm    83 FRVTLDAEELPKPPPPNPSNRLSRSALPALQLRNPLTQERKPEEDVMSTSVYVSSSTKPIAIPTK 147

  Fly   102 ---------ARLSS----------SRTSLSSSRQSLLGSRTQLTT-------------------- 127
                     .::|.          |..|.|....|::.|....|.
 Worm   148 QCRPPETDPMQMSMFSDMMDGSMFSNGSWSDIADSMITSNCTFTVRKGLPIDDDGDLMSVPMVQS 212

  Fly   128 ---------SLSERTASSSSIGPRK---------------------------------SLAPQNS 150
                     ...|:..||..:|..:                                 :.:.:||
 Worm   213 VFNIDREALRREEQLQSSIVLGESRIGVEHLPIIEDENELETPLVETRTMPLPNDLNANFSNKNS 277

  Fly   151 K----DKESPSTSLAEGA---------PAAS-GGNGAASHAS---------------SKRASFVE 186
            .    :.|:|...:.|..         |..| .|:...||.|               :|::..:|
 Worm   278 TTTFVEPETPKVEIRENGNLDNSIETPPQQSPSGSSMVSHESDSSSKKDDTKSDKSPTKKSQKME 342

  Fly   187 TGFLEILKPQFTPSQPLRSPSFTMPSNSGAEDKV------ALLEAQKT--SAELQAQLADLTEKL 243
            .  ..::|.:..|:.|...|.|.:...:.::.::      |.:||:||  ..|::::::.|....
 Worm   343 E--KPVVKKKEEPAAPPPPPKFPVKQKAPSKHQLMMEQLKASIEAEKTKPKKEIKSRVSLLPPPA 405

  Fly   244 ETLKQRRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQE 308
            ....|:.|::...:.|..:..|....|:....|   |:.|....:.|.|:|.|....|...
 Worm   406 PKAPQKENKEGGEMTETPRRTITKTPLKTVNAK---AKTSPTPPVERQKKERKPLYVAPPA---- 463

  Fly   309 MADLADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGG- 372
                          ||..|::.......:.|.....|:..|...:..:...:|......:.:||
 Worm   464 --------------KERVEKEKKIPSKPVVSPPTTAEKKPVVSSIPSTSSASKGPFPTSSFAGGK 514

  Fly   373 -----GDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQ-------KLSKELEMKRSEV 425
                 ..|...:|...|:.:...|..||.|.||:    |..|..:       :::::.|.|...:
 Worm   515 LQGPRKTSSSSTTTSAKKQKNPPIDEKEKLSRLQ----HSTHAFEATLIVMNRINEDNERKLGNI 575

  Fly   426 TELERTKEKLSAKIDELEAIVADLQEQVDAALGA-EEMVEQLAEKKMELEDKVKLLEEEIAQLEA 489
            :      |:...|:.||    .||::.:|.|... ||.|||:.....:      ::......:|:
 Worm   576 S------EQYEKKVSEL----GDLKKMLDEARKKFEEDVEQMKNSNQQ------VIRNHANAVES 624

  Fly   490 LEEVHE-QLVESNHELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVK-FRELVQKLND 552
            |::.|| |:.|.|.|.|.:..||           ...|:|.:..:.:|.|.:|. ..|.:.:...
 Worm   625 LQKTHETQIAEKNKEFERNFEEE-----------RARREAEVCAMNNRHQKVVACLDEKISEAEK 678

  Fly   553 QLTEL-----------------RDRNSSNEKESLQDPSLKMVTETIDYKQMFAESKAYTRAID-V 599
            |..:|                 |::..:.|..||| .:|:|  ::.:.|::..:::..:..:| :
 Worm   679 QCEQLNVDKKVLQAALANDCDHRNQMLTKEISSLQ-TALEM--KSAEMKELRQKNQNLSLQVDEI 740

  Fly   600 QLRQIELS----QANEHVQML 616
            .|:::|:|    ::||:.|||
 Worm   741 PLKELEISKWKHKSNEYKQML 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..73	CDD:460154	22/93 (24%)
		NIP100	13..>272	CDD:227569	73/412 (18%)
		SMC_prok_B	<219..>497	CDD:274008	59/300 (20%)
		Dynactin	550..834	CDD:463591	19/89 (21%)
		Smc	<965..>1080	CDD:440809
clip-1	NP_001022682.1	CAP_GLY	21..85	CDD:460154	21/66 (32%)
		PTZ00121	<364..793	CDD:173412	91/453 (20%)