DRSC/TRiP Functional Genomics Resources

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Protein Alignment DCTN1-p150 and DCTN1

DIOPT Version :9

Sequence 1:NP_524061.1 Gene:DCTN1-p150 / 39536 FlyBaseID:FBgn0001108 Length:1265 Species:Drosophila melanogaster
Sequence 2:NP_004073.2 Gene:DCTN1 / 1639 HGNCID:2711 Length:1278 Species:Homo sapiens


Alignment Length:1281 Identity:435/1281 - (33%)
Similarity:699/1281 - (54%) Gaps:101/1281 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
Human    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87

  Fly    67 FVRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSE 131
            |||.:|:::.|            .||..|          |..|..||:.:.|....|..|.    
Human    88 FVRQSQIQVFE------------DGADTT----------SPETPDSSASKVLKREGTDTTA---- 126

  Fly   132 RTASSSSIGPRKS-LAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195
            :|:....:.|:|: .|.:.:..:..|:...:.|...||...|.:..||:        |.|...:|
Human   127 KTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASA--------GELSSSEP 183

  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259
            . ||:| ||.:|....|..:.......|....|....|:||:.||.||||||:.:|.|||.:|:|
Human   184 S-TPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKE 247

  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
Human   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312

  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
Human   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366

  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
Human   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431

  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
Human   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496

  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
Human   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556

  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
Human   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621

  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
Human   622 IRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686

  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||..:....:.|.:
Human   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEDCTMQLADHI 750

  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843
            ....:|.:.:..:....:..:|.....:|..||::.|..:...:||..|.|:||:| :|...|.:
Human   751 KFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPA 815

  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906
            .|:  ....:.:....::::.:::.:.:....:...|....|::......|.:     |...:.|
Human   816 ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE-----LAFKASE 875

  Fly   907 RIYEQDDRGPTQNFKTLLAQAN---SDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQR 968
            :||......|   ::.|....|   |.:..:|..:.:.|||          .::..:...|:..|
Human   876 QIYGTPSSSP---YECLRQSCNILISTMNKLATAMQEGEYD----------AERPPSKPPPVELR 927

  Fly   969 AQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVD 1033
            |..::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::
Human   928 AAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 992

  Fly  1034 KWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHN 1098
            |.:.:.|||...|:.||||||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..
Human   993 KVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAEL--KQRLNSQSKRTIEGLRGPPPSG 1055

  Fly  1099 IS--LSG------NTSTAPGISNVSYSAP--AGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMR 1153
            |:  :||      .....||.:..|...|  ...:|::.:::..::...:|.:::...|:...|:
Human  1056 IATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMK 1120

  Fly  1154 AKLSQFEPLHVPQPQDQ----RITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVA----L 1210
            |.|:...||||.:...:    .:.|  ..|.|.....:.:|.|:.:...|...||....|    .
Human  1121 ASLASLPPLHVAKLSHEGPGSELPA--GALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSA 1183

  Fly  1211 QRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256
            |...|...|| .:|....:|..::|.|.:.::|.......||:||:
Human  1184 QLMEQVAQLK-SLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPS 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCTN1-p150NP_524061.1 CAP_GLY 8..74 CDD:214997 42/65 (65%)
Dynactin 553..834 CDD:289240 91/280 (33%)
DCTN1NP_004073.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 1/1 (100%)
CAP_GLY 30..94 CDD:279625 40/63 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..223 34/145 (23%)
FAM76 <135..292 CDD:292665 61/165 (37%)
CCDC144C 227..547 CDD:291576 151/330 (46%)
PCRF 246..>342 CDD:305100 54/95 (57%)
CASP_C 314..>455 CDD:285395 67/151 (44%)
Dynactin 525..805 CDD:289240 93/285 (33%)
Interaction with HPS6. /evidence=ECO:0000269|PubMed:25189619 911..1278 96/333 (29%)
FAM76 <952..1034 CDD:292665 40/83 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148747
Domainoid 1 1.000 309 1.000 Domainoid score I1340
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3011
Inparanoid 1 1.050 666 1.000 Inparanoid score I760
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53055
OrthoDB 1 1.010 - - D1550378at2759
OrthoFinder 1 1.000 - - FOG0005456
OrthoInspector 1 1.000 - - oto91418
orthoMCL 1 0.900 - - OOG6_100344
Panther 1 1.100 - - LDO PTHR18916
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4403
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.910

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