DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN1-p150 and Dctn1

DIOPT Version :9

Sequence 1:	NP_524061.1	Gene:	DCTN1-p150 / 39536	FlyBaseID:	FBgn0001108	Length:	1265	Species:	Drosophila melanogaster
Sequence 2:	NP_031861.2	Gene:	Dctn1 / 13191	MGIID:	107745	Length:	1281	Species:	Mus musculus

Alignment Length:	1287	Identity:	428/1287 - (33%)
Similarity:	695/1287 - (54%)	Gaps:	110/1287 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGM 66
            |.:.|:||:|||:.||...|||||||.|.||.||||||:|||.||||.|:::|::||.|||..|:
Mouse    23 SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGI 87

  Fly    67 FVRPTQLRLLE-AAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLS 130
            |||.:|:::.| .|..:.....|.|.:.....:...|...:|:......:::....:|.......
Mouse    88 FVRQSQIQVFEDGADTTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKP 152

  Fly   131 ERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKP 195
            .|.||:...||..||.|..|                ||.|..::|..|
Mouse   153 TRPASTGVAGPSSSLGPSGS----------------ASAGELSSSEPS----------------- 184

  Fly   196 QFTPSQ-PLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLRE 259
              ||:| ||.:|....|:.:.......|....|....|:||:.||.||||||:.:|:|||.:|:|
Mouse   185 --TPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKE 247

  Fly   260 FDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKE 324
            .:|.|||.||:||:::|:...||.||:.|..|::|||:|:||||::.:||||.||.:||.|||||
Mouse   248 LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312

  Fly   325 MAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQ 389
            ||||:|::||.|:|:.|||::||..|||:|::|::.|           |.....|:|:.||||:|
Mouse   313 MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEK-----------GSDGAASSYQLKQLEEQ 366

  Fly   390 NIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVD 454
            |.|||:.|||:||||:.:|.:..||.|.:|.|..|:..:.:.:|:|..::.:.|:.:.:|:||||
Mouse   367 NARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431

  Fly   455 AALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAK 519
            ||||||||||.|.::.:.||:||:.|.|.:..|||:.|::::|.|:..|.||:|||:||:|....
Mouse   432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496

  Fly   520 KEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYK 584
            :|..:..:||.||:.|..|||.|:|:|...|.|...||.::..::.:...|.|     .||.|:|
Mouse   497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP-----PETFDFK 556

  Fly   585 QMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDI 649
            ..|||:||:.:||:::|||:|::|||.|:.:||||||:||:..|||||.:||:||:.|::.|.::
Mouse   557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAEL 621

  Fly   650 VVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAG 714
            :..|.:|:|...:..:.....:|.|.:|.:|...|::.:..||..||:..:.|:.|..|...:.|
Mouse   622 IRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686

  Fly   715 SSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCV 779
            |..|||.|.|:.:|.:||||..:||||....:.:.|.:.::..:.|:.|| ||..:....:.|.:
Mouse   687 SLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEDSTMQLADHI 750

  Fly   780 ASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKS 843
            ....:|.:.:..:....:..:|.....:|..||::.|..:....||..|.|:||:| :|...|.:
Mouse   751 KFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPA 815

  Fly   844 GLS--QHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCE 906
            .|:  ....:.:....::::.:::.:     |.:||..:.:.:..|....||......|...:.|
Mouse   816 ALAFGSQVSDTLLDCRKHLTWVVAVL-----QEVAAAAAQLIAPLAENEGLPVAALEELAFKASE 875

  Fly   907 RIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQL 971
            :||......|.:..:.......|.:..:|..:.:.|||          .::..:...|:..||..
Mouse   876 QIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYD----------AERPPSKPPPVELRAAA 930

  Fly   972 IKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWK 1036
            ::.::.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..::|.:
Mouse   931 LRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQ 995

  Fly  1037 QKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNIS- 1100
            .:.:||...|:.|||:||||||.||:|||.||:||::|  |.:|||.:.:...|.....|..|:
Mouse   996 TRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAEL--KQRLNSQSKRTIEGLRGPPPSGIAT 1058

  Fly  1101 -LSGNTSTAPGISNVSYSAPAG--------TAPVVAEEVELLKNAFNQERNQRLRLQAQDMRAKL 1156
             :||.....|........||..        .:|::.:::..::...:|.:::...|:...|:|.|
Mouse  1059 LVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASL 1123

  Fly  1157 SQFEPLHVPQ----PQD------------QRITALESELTRMK-HAWVLSLLQVRSQDSVNSGTR 1204
            :...||||.:    |.:            ::.:.|..:|.::. |..|:.:  .||..:..|
Mouse  1124 AALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQLSTHTHVVDI--TRSSPAAKS--- 1183

  Fly  1205 IDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPT 1256
               .:.|...|...|| .:|....:|..::|.|.:.::|.......||:||:
Mouse  1184 ---PSAQLMEQVAQLK-SLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPS 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..74	CDD:214997	42/65 (65%)
DCTN1-p150	NP_524061.1	Dynactin	553..834	CDD:289240	91/280 (33%)
Dctn1	NP_031861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/2 (50%)
		CAP_GLY	30..94	CDD:279625	40/63 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..221		29/155 (19%)
		CCDC144C	227..547	CDD:291576	151/330 (46%)
		PCRF	246..>342	CDD:305100	54/95 (57%)
		CASP_C	314..>455	CDD:285395	67/151 (44%)
		Dynactin	525..805	CDD:289240	93/285 (33%)
		Interaction with HPS6. /evidence=ECO:0000269\|PubMed:25189619	911..1281		92/342 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838834
Domainoid	1	1.000	308	1.000	Domainoid score	I1337
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3011
Inparanoid	1	1.050	671	1.000	Inparanoid score	I739
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S4264
OMA	1	1.010	-	-		QHG53055
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005456
OrthoInspector	1	1.000	-	-		oto94999
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR18916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	1	1.000	-	-		X4403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740