Protein Alignment DCTN1-p150 and dctn1b

DIOPT Version :10

• Sequence 1: NP_524061.1
• Gene: DCTN1-p150 / 39536
• FlyBaseID: FBgn0001108
• Length: 1265
• Species: Drosophila melanogaster
• Sequence 2: XP_021336434.1
• Gene: dctn1b / 100003026
• ZFINID: ZDB-GENE-050419-28
• Length: 1264
• Species: Danio rerio
• Alignment Length: 1286
• Identity: 445/1286 - (34%)
• Similarity: 689/1286 - (53%)
• Gaps: 137/1286 - (10%)

  Fly     6 LKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFVRP 70
            :|||:.||:.||...|||||:|.|.||.||||||:||||||||.|:::|::||.|.||.|:|||.
Zfish    29 VKVGSLVEVIGKGHRGTVAYIGNTLFASGKWVGVILDEPKGKNDGTVQGKRYFLCQENHGIFVRQ 93

  Fly    71 TQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSERTAS 135
            :|::|:|            .||..|:.:..:|     .||....|:.:.|.::.......
Zfish    94 SQIQLVE------------DGADTTSPETPEA-----LTSKMLKREIIEGLKSNKVRGTK----- 136

  Fly   136 SSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKPQFTPS 200
                 |:|:...:.:..:....|....|....||...|...:||:.:               ||:
Zfish   137 -----PKKAPTTRKTTTRRPKQTRAGVGVKVGSGSASAGEMSSSEPS---------------TPA 181

  Fly   201 Q-PLRSPSFTMPSNSGA---EDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLREFD 261
            | ||.:|  .:||..||   .....:....|....|:|.:.||.|||||||.:|.|||.:|:|.:
Zfish   182 QTPLAAP--VIPSPVGALPSPGAPPIPGPSKEEESLRALVKDLEEKLETLKMKRTEDKAKLKELE 244

  Fly   262 KMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKEMA 326
            |.|||.|||||:::|:...|..|||:|..||:|||:|:||||::.:||||.||.:||.|||||||
Zfish   245 KHKIQLEQLQEWKSKMQEQQNELQKQLKEAKREAKEALEAKERYMEEMADTADAIEMATLDKEMA 309

  Fly   327 EEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQNI 391
            ||:|::||||.::.|||::||.:|||:|:.|::.|           |.....|:|..||||:||.
Zfish   310 EERAESLQLEADALKERVDELTMDLEILKHEIEEK-----------GSDGAASSYHVKQLEEQNA 363

  Fly   392 RLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVDAA 456
            ||||.|||:|||||.:|.:..|..|.:|.|..|:..|...||||..::...|..:.:|:|||||:
Zfish   364 RLKEALVRMRDLSASEKQEHGKQQKLMEKKNFELDALRCHKEKLQEEMKMAEKTIDELKEQVDAS 428

  Fly   457 LGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAKKE 521
            ||||||||.|.|:.::||:||:.|.|.:|.|||:.|::::|.|:..|.||:|||:|||.....:|
Zfish   429 LGAEEMVEMLTERNLDLEEKVRELRETVADLEAINEMNDELQENARETELELREQLDLGAAGVRE 493

  Fly   522 VLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYKQM 586
            ..:..:||.||:.|..|||.|:|||...|.:...||..:..:| .|..|.|:     |..|:|..
Zfish   494 AEKRVEAAQETVADYQQTIQKYRELTANLQEVNRELMSQQEAN-SEQQQQPA-----EIFDFKIK 552

  Fly   587 FAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVV 651
            |||:|||.:||:::||::|:.|||..|.:|.:|||:||:...||||.||.:|||.|::.|.:::.
Zfish   553 FAETKAYAKAIEMELRKMEVIQANRQVSLLISFMPDSFLKHRGDHDCILALLLIPRLICKSELIS 617

  Fly   652 SQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAGSS 716
            .|.:|:|...::.:::...:|...::.:|...|::.:..||.|||:..:.|:.|..|...|.||.
Zfish   618 KQAQEKFELTESCSQKPGMRGAVGERLSFAAGLIYSLTLLQAALHKYEHALSQCSVDVYKRVGSL 682

  Fly   717 LPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCVAS 781
            ..|:...|:.:|.:|:||..:.|||....:.:.|.:.::..:.|:.|| ||..:....:.|.:..
Zfish   683 YSELSVHERSLDFLIDLLYKDLLDETVNVEPLTKAIKYYQHLYSIHLA-EQPEDCTMQLADHIRF 746

  Fly   782 LGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLP-SDQHVIKSGL 845
            ..:|.:.:..:....:..||.........:|::.|:.:...:||..|.|:||:| :|...|.:.|
Zfish   747 TQSALDCMAVEVGRLRAFIQTGQDEEAFCVLLKDLDTSCSDIRQFCKKIRRRMPGTDAPGIPAAL 811

  Fly   846 SQHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYE 910
            | ...:....||.  ||...|...|..|.:||..:.:.:..:....||..|...:...:.|:||.
Zfish   812 S-FGPQVCEALAD--SRRQLAWVNAVLQEVAAAAAQLIAPLSEHEGLPAVKLEDMAFKAAEQIYG 873

  Fly   911 QDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQ 975
            .......:..:...:...:.:..:|..:.:.|||        |::.::|.  :|:..||..::.:
Zfish   874 SQGINAQECLRQSCSVVIATMNKMATAMQEGEYD--------SDRPQTGI--SPVEVRAAALRAE 928

  Fly   976 LEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWKQKYE 1040
            :.....|...||:||..:|:||.:.|:|..||||..:|..|.||||.....:.:..|:|.:...:
Zfish   929 ITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSASKDADERVEKIQAILD 993

  Fly  1041 ETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNI-SLSGN 1104
            ||...|:.||||||||||.||:|||.|||||.:|:.::             .|.|...| ||.|
Zfish   994 ETDSLLKKKEKEFEETMDALQADIDQLESEKVELKHRI-------------SSQSKMTIESLRG- 1044

  Fly  1105 TSTAPGISNV-----------SYSAPAG----TAPVVAEEVELLKNAFNQERNQRLRLQAQDMRA 1154
             |.|.||:::           ...|.||    .:|::.:::|..:.:....:|:..||:|:.|||
Zfish  1045 -SQASGIASIVTCGITAEEQKGVCAAAGLQVIDSPLLTQQIEAQRLSIKHLKNENNRLKAERMRA 1108

  Fly  1155 KLSQFEPLHVPQ---PQDQRITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVALQRRNQP 1216
            :|:...||:||:   .:..|...|.|.|.|.....:.:|||:    |.|    :..|.:..|: |
Zfish  1109 QLASLPPLNVPKLGWREGCRPEVLSSALYRKTDQLLDTLLQM----SAN----VKVVDITGRS-P 1164

  Fly  1217 VPLKGEISSKASQLASDILTEYLQR-----KPHRATH-------GQFASFP 1255
            |....::..:.::|.|  |.:.|.|     ..|..||       ..||:||
Zfish  1165 VSPSAQLLEQTARLQS--LNDTLDRLKDEVAEHVVTHRPGAQVSSDFATFP 1213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCTN1-p150	NP_524061.1	CAP_GLY	8..73	CDD:460154	40/64 (63%)
		NIP100	13..>272	CDD:227569	92/262 (35%)
		SMC_prok_B	<219..>497	CDD:274008	136/277 (49%)
		Dynactin	550..834	CDD:463591	85/283 (30%)
		Smc	<965..>1080	CDD:440809	48/114 (42%)
dctn1b	XP_021336434.1	CAP_GLY	31..96	CDD:460154	40/64 (63%)
		PRK02224	<212..>548	CDD:179385	167/352 (47%)
		Dynactin	522..799	CDD:463591	85/283 (30%)