DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8833 and TGH

DIOPT Version :9

Sequence 1:	NP_648669.1	Gene:	CG8833 / 39535	FlyBaseID:	FBgn0036386	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_197699.2	Gene:	TGH / 832372	AraportID:	AT5G23080	Length:	930	Species:	Arabidopsis thaliana

Alignment Length:	1073	Identity:	269/1073 - (25%)
Similarity:	428/1073 - (39%)	Gaps:	297/1073 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEEEHLHRFGTPLPALQKDVVPAKKPVA----------IEDQIVKDENGKRRFHGAFTGGFSAGF 56
            |||:.:.. |||:...::.....||.||          ...|.|.||.|:||||||||||:|||:
plant     4 DEEDFVFH-GTPIEREEEIASRKKKAVAGASGNLRTLPAWKQEVTDEEGRRRFHGAFTGGYSAGY 67

  Fly    57 WNTVGSLEGWTPQTFKSSRGERASSKAQLKPEDFMDQEDLGEF-GIAPQGIRTRDEFANEDEQKQ 120
            :|||||.|||.||:|.|||..||.::.| ...||:|:::..:. |.:.......|.|.....:..
plant    68 YNTVGSKEGWAPQSFTSSRQNRAGARKQ-SISDFLDEDEKADMEGKSLSASSQFDTFGFTAAEHS 131

  Fly   121 RSDQRRRKLMQPELGVGAIPGLPVLEQLLRPVRDKVAVRILKSMGWKPGQGVGPRQTRKEKRQAT 185
            |....:.:..:|    .|||| ||.::|:.||.:.:.|::|..|||:.|..:      ||.|.::
plant   132 RKHAEKEQHERP----SAIPG-PVPDELVAPVSESIGVKLLLKMGWRRGHSI------KEVRASS 185

  Fly   186 -ARNSKEQYLMEHYGAEGLPSNKENKGEEDSNNEDEDD--EDITFAPDDYEPIF-YTPKENRFGM 246
             ||....:..:..|..|   :.||......|..|.|..  |||..:  :..|:: ..||::..|:
plant   186 DARREARKAFLAFYTDE---NTKETPDSLVSETEVETSLGEDIKIS--ESTPVYVLNPKQDLHGL 245

  Fly   247 SYSGLNRDPILSKSSSSSAKPMQHINLFGEME---AQANK-----KQLSIR-----------GQA 292
            .|.                 |.:|...|.|.:   ..|||     |.||::           ...
plant   246 GYD-----------------PFKHAPEFREKKRSRMSANKEVGFRKPLSMKESLFGPKSGKIAPG 293

  Fly   293 FGVGAFEE---EDEDIYARDDMTRYDFS----LADKKPKQKKQQH-----VQQRHVIDGF-SEDN 344
            ||:||.||   ||||:||     .|||.    :.|::|.::...:     .::..|:.|| :..|
plant   294 FGIGALEELDVEDEDVYA-----GYDFDQTYVIEDEQPARQSNDNRLRLTSKEHDVLPGFGAAKN 353

  Fly   345 SPAVLQRPYAIDLPRDFQPRNWLQRRSRFA-PMDKERAQKLETASE------------------- 389
            |...::|.....:|:||..|:      :|: |::.|....:....|
plant   354 SDYSMERFNPPIIPKDFVARH------KFSGPLEAETKPTVSAPPEVPPPADNNLKLLIEGFATF 412

  Fly   390 YKRSGLGRHDLN--PDQRAQIL-------GEQQQEEKTAEEQPKRNPFKDHSK--------SLME 437
            ..|.|....||:  .:|..|:.       |......:..|||.||   ||.||        ..::
plant   413 VSRCGKLYEDLSREKNQSNQLFDFLREGNGHDYYARRLWEEQQKR---KDQSKLTLDVKVSPTVQ 474

  Fly   438 RINARTEGFTKGGVITENGEEQQTELAKEVKEANAAIQERAALK---------TKDLPSAMNSSS 493
            ::.|.|.|...|          :..|.:.:||.:.:.....:.:         ||. .|:..::.
plant   475 KMTAETRGSLLG----------EKPLQRSLKETDTSASSGGSFQFPTNLSDTFTKS-ASSQEAAD 528

  Fly   494 AFKPFIADEAKQLRYEKFVSSK------LTDDKEITEFLARMQPVTLSLWDREMEKKEF------ 546
            |.|||..|.|||.|:|:|:..|      .||...:.         ::|...|..|:.:|
plant   529 AVKPFKDDPAKQERFEQFLKEKYKGGLRTTDSNRVN---------SMSESARAQERLDFEAAAEA 584

  Fly   547 IQAAKIYR--------PLVGLMND-RFVSEANVQAEKVEQQEKPPEERKIVMERTKTMWKPTALL 602
            |:..|.|:        ||..|... :|.|....|.:.....:.  :..|...:|.:..|:|:.||
plant   585 IEKGKAYKEVRRATEQPLDFLAGGLQFTSGGTEQIKDTGVVDM--KSSKTYPKREEFQWRPSPLL 647

  Fly   603 CKRYNIAEPFGGAMLEPEKELKAKAKISVFDYLETSVN-TKANFETPSIFPKHIEKSIPEKVETP 666
            |||:::.:||.| .|.|..  :|:.|:....:|..:|. ..|...:.|..||. |.||.|
plant   648 CKRFDLPDPFMG-KLPPAP--RARNKMDSLVFLPDTVKAASARQVSESQVPKK-ETSIEE----- 703

  Fly   667 PSPPPAPQPEAEIQDKPNTKEEPSKHTFVPKTPLEQAVDESRNKPISEKVDLFKSIFEDSDEEET 731
                  |:.|.|:::                              :...|||:|:||.|..|::.
plant   704 ------PEVEVEVEN------------------------------VERPVDLYKAIFSDDSEDDE 732

  Fly   732 ELSEQDKLAILQESFGLPVTSTTSAAAQNVLRNTSPPRGIFASLFSPKIKDAAKEPAPTKFGPIE 796
            :.....|:...||       ....|||..:.|       :.|..|   ::...||
plant   733 DQPMNGKIQEGQE-------KKNEAAATTLNR-------LIAGDF---LESLGKE---------- 770

  Fly   797 GSKLKIAYK-PRKERLRNDRELAMAEVAPEDIYGPKLPTAPPQKPAAPEIQAEANIDDRLQQ--L 858
                 :.:: |.:|.:::..:       |||....:|     .:|...|     .::::...  |
plant   771 -----LGFEVPMEEEIKSRSK-------PEDSSDKRL-----DRPGLKE-----KVEEKTSSLTL 813

  Fly   859 WQQHAPKKRKAEKWVEKKCISGSEDSDASSSNESSSSDSSDDNDKRSKLSKPKK----SHKGSSS 919
            ..:....::|.||...|:          |..|:.|||:||.|..:|.:.:|..:    |...|||
plant   814 GSEEEKSRKKREKSPGKR----------SGGNDLSSSESSGDERRRKRYNKKDRHRNDSESDSSS 868

  Fly   920 KKSKKSKLKSKKKSKKSEESKHKAKKKKKKSKH 952
            ....:.|..|:.:||:.|.|:.|....||.|||
plant   869 DYHSRDKQGSRSRSKRRESSREKRSSHKKHSKH 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8833	NP_648669.1	DUF1604	27..112	CDD:400178	42/95 (44%)
CG8833	NP_648669.1	G-patch	154..201	CDD:396249	12/47 (26%)
TGH	NP_197699.2	DUF1604	39..120	CDD:285014	39/81 (48%)
TGH	NP_197699.2	Surp	405..452	CDD:280053	7/46 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2902
eggNOG	1	0.900	-	-		E1_KOG2138
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I1357
OMA	1	1.010	-	-		QHG56126
OrthoDB	1	1.010	-	-		D1175081at2759
OrthoFinder	1	1.000	-	-		FOG0005405
OrthoInspector	1	1.000	-	-		oto2993
orthoMCL	1	0.900	-	-		OOG6_103645
Panther	1	1.100	-	-	LDO	PTHR13384
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3832
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840