DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8833 and gpatch1

DIOPT Version :9

Sequence 1:	NP_648669.1	Gene:	CG8833 / 39535	FlyBaseID:	FBgn0036386	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_012816714.2	Gene:	gpatch1 / 733839	XenbaseID:	XB-GENE-953282	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	1020	Identity:	320/1020 - (31%)
Similarity:	484/1020 - (47%)	Gaps:	215/1020 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEEEHLHRFGTPLPALQKDVVPAKKPVAIEDQIVKDENGK-RRFHGAFTGGFSAGFWNTVGSLEG 65
            |.||....:|.||...|:...| |||:|::||.||||.|: :|||||||||||||::||||:.||
Frog     7 DSEEDFVTYGKPLEQYQEGEQP-KKPIALQDQTVKDEKGRYKRFHGAFTGGFSAGYFNTVGTKEG 70

  Fly    66 WTPQTFKSSRGERASSKAQLKPEDFMDQEDLGEFGIAPQGIRTRDEFANEDEQKQRSDQRRRKLM 130
            |||.||.|||..| |.:|..:||||||:||||||||||..|.|.|.||:  :.|.|..::.|:|
Frog    71 WTPSTFVSSRQGR-SERAVSRPEDFMDEEDLGEFGIAPTEILTTDNFAS--KSKDRIREKAREL- 131

  Fly   131 QPELGVGA-IPGLPVLEQLLRPVRDKVAVRILKSMGWKPGQGVGPRQTRKEKRQATARNSKEQYL 194
               ..|.| |||..:|:.|:.|.:..:.:::|:.||||.|||||||..|:.::|      |.:..
Frog   132 ---ASVSAPIPGATILDDLIAPAKITIGIQLLRQMGWKEGQGVGPRTKRRAQKQ------KPESY 187

  Fly   195 MEHYGAEGLPSNKENKGEEDSNNEDEDD----EDITFAPDDYEPIFYTPKENRFGMSYSGLNRDP 255
            :..||....|:..|       .:|||:|    |::||||.|...|.:|.|:|..|:.|.||  ||
Frog   188 VRMYGCALPPAGSE-------GSEDEEDEYVPENVTFAPKDVIQIDFTMKDNVHGLGYRGL--DP 243

  Fly   256 ILSKSSSSSAKPMQHINLFGEMEAQANK----------KQLSIRGQAFGVGAFEEEDEDIYARDD 310
                |.:......:||:|||:...:.|.          :::.:.||||||||.||||:|||.|:.
Frog   244 ----SQALFGSQEKHIHLFGDGYEKMNSLLRDNQHSRGRKVGMSGQAFGVGALEEEDDDIYGRES 304

  Fly   311 MTRYDFSL-------------ADKKPKQKKQQH---VQQRHVIDGFSEDNSPAVLQRPYA-IDLP 358
            :::||..|             |.|:.|.:|..|   |....::||:.....||..::.|| .:||
Frog   305 LSKYDTVLCEEESGDGLFGWTAPKEYKNRKGLHKELVYVGKILDGYCTAMKPAAPKKVYAPPELP 369

  Fly   359 RDFQPRNWLQRRSRFAPMDKERAQKLETASEYKRSGL----GRHDLNPDQRAQILGEQQQEEKTA 419
            :|::|.::.:.....:.::....|.|..:|:...|..    .||.||.|||.::||
Frog   370 KDYRPVHYFKPVLNTSNLNSPALQALLDSSQKPPSDAATKQSRHHLNSDQRREMLG--------- 425

  Fly   420 EEQPKRNP------FKDHSKSLMERINARTEGF-TKGGVITENGEEQQTELAKEVKEANAAIQER 477
             |.|.:.|      ..|..:..::.:....|.. .|...:.|...:|:.:| |..||..  :||
Frog   426 -ETPLQGPSSVLELLSDKDRERIQDVKHAVEQHRIKAQKLAEEAAKQRFQL-KSAKETQ--LQE- 485

  Fly   478 AALKTKDLPSAMNSSSAFKPFIADEAKQLRYEKFVSSKLTDDKEITE-FLARMQPVTLSLWDREM 541
             :.:.|:|..|  .|..|:||..:..||.|||.:|.:....:|:..| .|.|    .::.|:||.
Frog   486 -SPQRKELVPA--HSGDFRPFEKNPEKQKRYETYVKNFHKGEKDALENCLDR----NMTEWERER 543

  Fly   542 EKKEFIQAAKIYRPLVGLMNDRFV-SEANVQAEKVE---QQEKPPEERKIVME--------RTKT 594
            |::||:::|.:|:.....::.||. ::.:...:|||   .||....::...::        |...
Frog   544 EREEFMRSAMLYKSSSSTLSSRFTRAKYDDNTDKVEVPRDQESDAGDKSAAVKMKMFGKLTRDTF 608

  Fly   595 MWKPTALLCKRYNIAEPFGGAMLEPEKELKAKAKISVFDYLETSVNTKANFETPSIFPKHIEKSI 659
            .|.|..|||||:||.:|:.|:.:....::| :.|.|||::|..:.|.|.: ||..:......::.
Frog   609 EWHPDKLLCKRFNIPDPYPGSTIVGLPKVK-RDKFSVFNFLTVAENPKTH-ETNEMLKPCTAENK 671

  Fly   660 PEKV-----------ETPPSPPPAPQPEAEIQDKPNTKEEPSKHTFVPKTPLEQA--VDESRNKP 711
            |:|:           ||      |.....:|.|:.......:..|..||...||.  :::...:|
Frog   672 PKKLSRWDVSGRNQEET------ASNVNKQIPDQTAKDTNKATSTLPPKIITEQTDQIEDEEKRP 730

  Fly   712 ISEKVDLFKSIFEDSDEEETELSEQDKLAILQESFGLPVTSTTSAAAQNVLRNTSPPRGIFASLF 776
               .:||||:|||||.:|::..||::..|   |....|:|:|..|...|
Frog   731 ---SIDLFKAIFEDSSDEKSSSSEEESDA---EESSTPITNTQRAEPMN---------------- 773

  Fly   777 SPKIKDAAKEPAPTKFGPIEGSKLKIAYKPRKERLRNDRELAMAEVAPEDIYGPKLPTAPPQKPA 841
                 ..|.||.|....|:..:..|:...|.             .:.||:.:|||||      ||
Frog   774 -----SKAPEPEPEIQQPVLSAAPKVKEVPE-------------VIHPEEEFGPKLP------PA 814

  Fly   842 APEIQAEANIDDRLQQLWQQHAPKKRKAEKWVEKKCISGSEDSDASSSNESSSSDSSDDNDKRSK 906
            .|                                        |.||..|:.:....||::.|:.|
Frog   815 LP----------------------------------------SSASGGNKFTLHPISDESVKKQK 839

  Fly   907 LSK-PKKSHKGSSSKKSKKSKLKSKKKSKKSEESKHKAKKKKKKS 950
            .:| .|:.||.....|.||.|.|..||.|  .::|||:||.:.||
Frog   840 HNKRDKEKHKLKKGHKHKKEKKKKHKKQK--HKNKHKSKKAEDKS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8833	NP_648669.1	DUF1604	27..112	CDD:400178	58/85 (68%)
CG8833	NP_648669.1	G-patch	154..201	CDD:396249	17/46 (37%)
gpatch1	XP_012816714.2	DUF1604	31..116	CDD:400178	58/85 (68%)
gpatch1	XP_012816714.2	G-patch	155..>180	CDD:396249	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2634
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1992
OMA	1	1.010	-	-		QHG56126
OrthoDB	1	1.010	-	-		D1175081at2759
OrthoFinder	1	1.000	-	-		FOG0005405
OrthoInspector	1	1.000	-	-		oto105096
Panther	1	1.100	-	-	LDO	PTHR13384
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1921
SonicParanoid	1	1.000	-	-		X3832
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110