DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8833 and Gpatch1

DIOPT Version :9

Sequence 1:	NP_648669.1	Gene:	CG8833 / 39535	FlyBaseID:	FBgn0036386	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_080457.1	Gene:	Gpatch1 / 67471	MGIID:	1914721	Length:	930	Species:	Mus musculus

Alignment Length:	1071	Identity:	314/1071 - (29%)
Similarity:	473/1071 - (44%)	Gaps:	308/1071 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEEEHLHRFGTPLPALQKDVVPAKKPVAIEDQIVKDENGK-RRFHGAFTGGFSAGFWNTVGSLEG 65
            |.:|.|..:||.|..|.:...| |||:.::||.|:||.|: :||||||:||||||::|||||.||
Mouse     7 DSDEDLISYGTGLEPLDEGERP-KKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEG 70

  Fly    66 WTPQTFKSSRGERASSKAQLKPEDFMDQEDLGEFGIAPQGIRTRDEFANEDEQKQRSDQRRRKLM 130
            |||.||.|||..|| .|:.|.||||||:|||.||||||:.|.|.|:||::.:     |:.|.|..
Mouse    71 WTPSTFVSSRQNRA-DKSALGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTK-----DRIREKAR 129

  Fly   131 QPELGVGAIPGLPVLEQLLRPVRDKVAVRILKSMGWKPGQGVGPRQTRKEKRQATARNSKEQYLM 195
            |.......|||..:|:.|:.|.:..|...:|:.||||.|||||||..||.:||      |....:
Mouse   130 QLAAAAAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRKARRQ------KPDPGV 188

  Fly   196 EHYGAEGLPSNKENKGEEDSNNEDED--DEDITFAPDDYEPIFYTPKENRFGMSYSGLNRDPILS 258
            :.||. .||..    |.|:|.:||:|  .:::||||.|..|:.:|||:|..|::|.||  ||
Mouse   189 KIYGC-ALPPG----GSEESEDEDDDYLPDNVTFAPKDVMPVDFTPKDNVHGLAYKGL--DP--- 243

  Fly   259 KSSSSSAKPMQHINLFGEME----------AQANKKQLSIRGQAFGVGAFEEEDEDIYARDDMTR 313
             ..:....|.:|:||||...          ..:..::|.|.||||||||.||||:||||.:.:::
Mouse   244 -HQALFGMPGEHLNLFGGASEGTSHLLGDVGLSKGRKLGISGQAFGVGALEEEDDDIYATETLSK 307

  Fly   314 YDFSLADKK----------PKQKKQQHVQQR------HVIDGFSEDNSPAVLQRPY-AIDLPRDF 361
            ||..|.|::          |||.|.|...:|      .:::|||..:.|...::.| ...||||:
Mouse   308 YDTVLKDEEPGDGLYGWTAPKQYKNQKEPERDLRYVGKILEGFSLASKPLSSKKIYPPPQLPRDY 372

  Fly   362 QPRNWLQRRSRFAPM---DKERAQKLETASEYK-RSGL-----GRHDLNPDQRAQILGEQQQEEK 417
            :|.::      |.|:   ..|.|..|:..||.. ::|.     .||.||..:|.::|||.
Mouse   373 RPVHY------FRPVVAATAENAHVLQVLSESSGKAGQDVGTHSRHQLNASKRGELLGEM----- 426

  Fly   418 TAEEQPKRNPFKDHSKSLMERINARTEGFTKGGVITENGEEQQTELAKEVKE------------- 469
                     |.:..:.|::|.::                 ::..|..||||:
Mouse   427 ---------PIQGSATSVLEFLS-----------------QKDKERIKEVKQATDLKAAQAKARS 465

  Fly   470 -ANAAIQERAALKTKDL-----------PSAMNSSSAFKPFIADEAKQLRYEKFVSSKLTDDKEI 522
             |.:|...||...|.||           .:....::.||||..|..||.|||:|:.......|:.
Mouse   466 LAQSASSSRAQASTPDLGHSSWHLALGGGTVTTRANNFKPFAKDPEKQRRYEEFLVHMKKGQKDA 530

  Fly   523 TEFLARMQPVTLSLWDREMEKKEFIQAAKIYRPLVGLMNDRFVSEANVQAEKVEQQEKPPEERKI 587
            .|   |....:::.|:|..|::||.:||::|......::.||....  :.|..:|.|.|.::...
Mouse   531 LE---RCLDPSMTEWERSREREEFARAAQLYVSSNSTLSSRFTHAK--EEEDSDQVEVPRDQEND 590

  Fly   588 VMERTKTM--------------WKPTALLCKRYNIAEPFGGAMLEPEKELKAKAKISVFDYLETS 638
            |.::...:              |.|..|||||:|:.:|:.|:.|.....:| :.|.|||::|
Mouse   591 VSDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPGSTLVGLPRVK-RDKYSVFNFL--- 651

  Fly   639 VNTKANFETPSIFPKHIEKSIPEKVETPPSPPP---APQPE-AEIQDKPN-------TKEEPSKH 692
                               ::||....|.:|.|   |||.. ::...||:       .|:|.|..
Mouse   652 -------------------TLPEPAPLPTAPVPSEKAPQQRGSDKSRKPSRWDTSKQEKKEDSIS 697

  Fly   693 TFV----------------------------PKTPLEQAVD-ESRNKPISEKVDLFKSIFEDSDE 728
            .|:                            |.|.:::||| ::..:.....:||||:||..|.:
Mouse   698 EFLSQARSKVGPPKQESSALGSKEEQAPEPRPDTTVDKAVDAQTDGEGSRPSMDLFKAIFASSSD 762

  Fly   729 EETELSEQDKLAILQESFGLPVTSTTSAAAQNVLRNTSPPRGIFASLFSPKIKDAAKEPAPTKFG 793
            |::..||:::                                          .|:......|:..
Mouse   763 EKSSSSEEEQ------------------------------------------DDSEDSQEHTEEA 785

  Fly   794 PIEGSKLKIAYKPRKERLRNDRELAMAEVAPEDIYGPKLPTAPPQKPAAPEIQAEANIDDRLQ-- 856
            .::||         :|....:..:.:| ..||           |.:||.|....:|.||:|.:
Mouse   786 SLKGS---------QEAAAGETSVVLA-AEPE-----------PCEPATPFPIQKAQIDEREEFG 829

  Fly   857 -QLWQQHAPKKRKAEKWVEKKCISGSEDSDASSSNESSSSDSSDDNDKRSKLSKPKKSHKGSSSK 920
             :|.....|..|:..:..:|:                                |||||.:...||
Mouse   830 PRLPPVFCPNSRQKLEIPQKE--------------------------------KPKKSKERHKSK 862

  Fly   921 KSKKSKLKSKKKSKKSEESKHKAKKKKKKSK 951
            |..:.|.:.|||.||   .|||:|:|.|||:
Mouse   863 KEHRRKREKKKKHKK---HKHKSKQKNKKSE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8833	NP_648669.1	DUF1604	27..112	CDD:400178	56/85 (66%)
CG8833	NP_648669.1	G-patch	154..201	CDD:396249	20/46 (43%)
Gpatch1	NP_080457.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		14/34 (41%)
		DUF1604	31..116	CDD:285014	56/85 (66%)
		G-patch	154..>172	CDD:279867	9/17 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..209		19/49 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..420		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..486		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..596		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..930		71/335 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850112
Domainoid	1	1.000	197	1.000	Domainoid score	I3116
eggNOG	1	0.900	-	-		E1_KOG2138
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2179
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56126
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005405
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103645
Panther	1	1.100	-	-	LDO	PTHR13384
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1921
SonicParanoid	1	1.000	-	-		X3832
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790