DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8833 and GPATCH1

DIOPT Version :9

Sequence 1:	NP_648669.1	Gene:	CG8833 / 39535	FlyBaseID:	FBgn0036386	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_060495.2	Gene:	GPATCH1 / 55094	HGNCID:	24658	Length:	931	Species:	Homo sapiens

Alignment Length:	1073	Identity:	312/1073 - (29%)
Similarity:	462/1073 - (43%)	Gaps:	314/1073 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEEEHLHRFGTPLPALQKDVVPAKKPVAIEDQIVKDENGK-RRFHGAFTGGFSAGFWNTVGSLEG 65
            |.||.|..:||.|..|::...| |||:.::||.|:||.|: :||||||:||||||::|||||.||
Human     7 DSEEDLVSYGTGLEPLEEGERP-KKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEG 70

  Fly    66 WTPQTFKSSRGERASSKAQLKPEDFMDQEDLGEFGIAPQGIRTRDEFANEDEQKQRSDQRRRKLM 130
            |||.||.|||..|| .|:.|.||||||:|||.||||||:.|.|.|:||::.:     |:.|.|..
Human    71 WTPSTFVSSRQNRA-DKSVLGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTK-----DRIREKAR 129

  Fly   131 QPELGVGAIPGLPVLEQLLRPVRDKVAVRILKSMGWKPGQGVGPRQTRKEKRQATARNSKEQYLM 195
            |.......|||..:|:.|:.|.:..|...:|:.||||.|||||||..|:.:||      |....:
Human   130 QLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRRPRRQ------KPDPGV 188

  Fly   196 EHYGAEGLPSNKENKGEEDSNNEDED--DEDITFAPDDYEPIFYTPKENRFGMSYSGLNRDPILS 258
            :.||....|.:.|.     |..||:|  .:::||||.|..|:.:|||:|..|::|.||:....|.
Human   189 KIYGCALPPGSSEG-----SEGEDDDYLPDNVTFAPKDVTPVDFTPKDNVHGLAYKGLDPHQALF 248

  Fly   259 KSSSSSAKPMQHINLF-------GEM-EAQANK-KQLSIRGQAFGVGAFEEEDEDIYARDDMTRY 314
            .:|.      :|.|||       |:: |...|| ::|.|.||||||||.||||:||||.:.:::|
Human   249 GTSG------EHFNLFSGGSERAGDLGEIGLNKGRKLGISGQAFGVGALEEEDDDIYATETLSKY 307

  Fly   315 DFSLADKKP-------------KQKKQQHVQQRHV---IDGFSEDNSPAVLQRPY-AIDLPRDFQ 362
            |..|.|::|             |.:|:.....|:|   :||||..:.|...::.| ..:||||::
Human   308 DTVLKDEEPGDGLYGWTAPRQYKNQKESEKDLRYVGKILDGFSLASKPLSSKKIYPPPELPRDYR 372

  Fly   363 PRNWLQRRSRFAPM---DKERAQKLETASEYKRSGL------GRHDLNPDQRAQILGEQQQEEKT 418
            |.::      |.||   ..|.:..|:..||......      .:|.||..:||::|||
Human   373 PVHY------FRPMVAATSENSHLLQVLSESAGKATPDPGTHSKHQLNASKRAELLGE------- 424

  Fly   419 AEEQPKRNPFKDHSKSLMERINARTEGFTKGGVITENGEEQQTELAKEVKEANAAIQERAALKTK 483
                   .|.:..:.|::|.::                 ::..|..||:|:|...  :.|.||.:
Human   425 -------TPIQGSATSVLEFLS-----------------QKDKERIKEMKQATDL--KAAQLKAR 463

  Fly   484 DLPSAMNSSSA----------------------------FKPFIADEAKQLRYEKFVSSKLTDDK 520
            .|.....||.|                            ||||..|..||.||::|:.......|
Human   464 SLAQNAQSSRAQLSPAAAAGHCSWNMALGGGTATLKASNFKPFAKDPEKQKRYDEFLVHMKQGQK 528

  Fly   521 EITEFLARMQPVTLSLWDREMEKKEFIQAAKIYRPLVGLMNDRFVSEANVQAEKVEQQEKPPEER 585
            :..|   |....:::.|:|..|:.||.:||.:|......::.||....  :.:..:|.|.|.::.
Human   529 DALE---RCLDPSMTEWERGRERDEFARAALLYASSHSTLSSRFTHAK--EEDDSDQVEVPRDQE 588

  Fly   586 KIVMERTKTM--------------WKPTALLCKRYNIAEPFGGAMLEPEKELKAKAKISVFDYLE 636
            ..|.::...:              |.|..|||||:|:.:|:..:.|.....:| :.|.|||::|.
Human   589 NDVGDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVK-RDKYSVFNFLT 652

  Fly   637 TSVNTKANFETPSIFPKHIEKSIPEKVETPPSPPPAPQPE--------------AEIQDKPNTKE 687
            ..       ||.|:   ...::..|||.....|..:.:|.              :|......:|.
Human   653 LP-------ETASL---PTTQASSEKVSQHRGPDKSRKPSRWDTSKHEKKEDSISEFLSLARSKA 707

  Fly   688 EPSKHTFVPKTPL-----EQAVDESRNKPISEKV-------------DLFKSIFEDSDEEETELS 734
            ||.|.   ..:||     |.|.:.|.|:.:::.|             |||::||..|.:|::..|
Human   708 EPPKQ---QSSPLVNKEEEHAPELSANQTVNKDVDAQAEGEGSRPSMDLFRAIFASSSDEKSSSS 769

  Fly   735 EQDK-----------LAILQESFGLPVTSTTSAAAQNVLRNTSPPRGIFASLFSPKIKDAAKEPA 788
            |.::           .|..|.|....:..|:|.|...|                    .|.:||.
Human   770 EDEQGDSEDDQAGSGEANFQSSQDTDLGETSSVAHALV--------------------PAPQEPP 814

  Fly   789 PTKFGPIEGSKLKIAYKPRKERLRNDRELAMAEVAPEDIYGPKLPTAPPQKPAAPEIQAEANIDD 853
            |:  .||:    |:....|:|                  :||:||  |...|.|
Human   815 PS--FPIQ----KMQIDEREE------------------FGPRLP--PVFCPNA----------- 842

  Fly   854 RLQQLWQQHAPKKRKAEKWVEKKCISGSEDSDASSSNESSSSDSSDDNDKRSKLSKP-KKSHKGS 917
                                                              |..|..| |:.||.:
Human   843 --------------------------------------------------RQTLEVPQKEKHKKN 857

  Fly   918 SSK-KSKKSKLKSKKKSKKSEESKHKAKKKKKK 949
            ..| |:||...:.|:|.||..:.|||.|:|.||
Human   858 KDKHKAKKEHRRKKEKKKKHRKHKHKGKQKNKK 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8833	NP_648669.1	DUF1604	27..112	CDD:400178	56/85 (66%)
CG8833	NP_648669.1	G-patch	154..201	CDD:396249	19/46 (41%)
GPATCH1	NP_060495.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		15/34 (44%)
		DUF1604	31..116	CDD:285014	56/85 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..92		10/19 (53%)
		G-patch	154..181	CDD:279867	14/26 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..209		17/50 (34%)
		DAGK_cat	403..>486	CDD:294771	23/115 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..595		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..931		70/345 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159743
Domainoid	1	1.000	182	1.000	Domainoid score	I3475
eggNOG	1	0.900	-	-		E1_KOG2138
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2299
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56126
OrthoDB	1	1.010	-	-		D1175081at2759
OrthoFinder	1	1.000	-	-		FOG0005405
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103645
Panther	1	1.100	-	-	LDO	PTHR13384
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1921
SonicParanoid	1	1.000	-	-		X3832
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800