DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8833 and Gpatch1

DIOPT Version :9

Sequence 1:	NP_648669.1	Gene:	CG8833 / 39535	FlyBaseID:	FBgn0036386	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001099716.1	Gene:	Gpatch1 / 292810	RGDID:	1308935	Length:	930	Species:	Rattus norvegicus

Alignment Length:	1056	Identity:	320/1056 - (30%)
Similarity:	475/1056 - (44%)	Gaps:	278/1056 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEEEHLHRFGTPLPALQKDVVPAKKPVAIEDQIVKDENGK-RRFHGAFTGGFSAGFWNTVGSLEG 65
            |.||.|..:||.|..|::...| |||:.::||.|:||.|: :||||||:||||||::|||||.||
  Rat     7 DSEEDLISYGTGLEPLEEGERP-KKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAGYFNTVGSKEG 70

  Fly    66 WTPQTFKSSRGERASSKAQLKPEDFMDQEDLGEFGIAPQGIRTRDEFANEDEQKQRSDQRRRKLM 130
            |||.||.|||..|| .|:.|.||||||:|||.||||||:.|.|.|:||::.:     |:.|.|..
  Rat    71 WTPSTFVSSRQNRA-DKSALGPEDFMDEEDLSEFGIAPKAIVTTDDFASKTK-----DRIREKAR 129

  Fly   131 QPELGVGAIPGLPVLEQLLRPVRDKVAVRILKSMGWKPGQGVGPRQTRKEKRQATARNSKEQYLM 195
            |.......|||..:|:.|:.|.:..|...:|:.||||.|||||||..||.:||      |....:
  Rat   130 QLAAAAAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRKARRQ------KADPGV 188

  Fly   196 EHYGAEGLPSNKENKGEEDSNNEDED--DEDITFAPDDYEPIFYTPKENRFGMSYSGLNRDPILS 258
            :.||. .||..    |.|.|.:||:|  .:::||||.|..|:.:|||:|..|::|.||  ||
  Rat   189 KIYGC-ALPPG----GSEGSEDEDDDYLPDNVTFAPKDVMPVDFTPKDNVHGLAYKGL--DP--- 243

  Fly   259 KSSSSSAKPMQHINLFGEME----------AQANKKQLSIRGQAFGVGAFEEEDEDIYARDDMTR 313
             ..:....|.:|:||||...          ..:..::|.|.||||||||.||||:||||.:.:::
  Rat   244 -HQALFGMPGEHLNLFGGASEGTSHLLGDVGLSKGRKLGISGQAFGVGALEEEDDDIYATETLSK 307

  Fly   314 YDFSLADKK----------PKQKKQQHVQQR------HVIDGFSEDNSPAVLQRPY-AIDLPRDF 361
            ||..|.|::          |||.|.....:|      .:::|||..:.|...::.| ..:||||:
  Rat   308 YDTVLKDEEPGDGLYGWTAPKQYKNHKEPERDLRYVGKILEGFSLASKPLSSKKIYPPPELPRDY 372

  Fly   362 QPRNWLQRRSRFAPM---DKERAQKLETASEYK-RSG--LG---RHDLNPDQRAQILGEQQQEEK 417
            :|.::      |.|:   ..:.|..|:..||.. ::|  :|   ||.||..:|.::|||.
  Rat   373 RPVHY------FRPVVAATSKNAHLLQVLSESSGKAGQDMGTHSRHQLNASKRGELLGEM----- 426

  Fly   418 TAEEQPKRNPFKDHSKSLMERINARTEGFTKGGVITENGEEQQTELAKEVKE------------- 469
                     |.:..:.|::|.::                 ::..|..||||:
  Rat   427 ---------PVQGSATSVLEFLS-----------------QKDKERIKEVKQATDLKAAQAKARS 465

  Fly   470 -ANAAIQERAALKTKDLPS------AMNS------SSAFKPFIADEAKQLRYEKFVSSKLTDDKE 521
             |.:|...||...|.| |.      |:.|      :|.||||..|..||.|||:|:.......|:
  Rat   466 LAQSASSSRAQASTPD-PGHSSWHLALGSGTVTTRASNFKPFAKDPEKQRRYEEFLVHMKKGQKD 529

  Fly   522 ITEFLARMQPVTLSLWDREMEKKEFIQAAKIYRPLVGLMNDRFV----SEANVQAEKVEQQEKPP 582
            ..|   |.....::.|:|..|::||.:||::|......::.||.    .:.:.|.|....||...
  Rat   530 ALE---RCLDPNMTEWERSREREEFARAAQLYVSSNSTLSSRFTHAKEEDDSDQVEVPRDQENDL 591

  Fly   583 EERKIVME--------RTKTMWKPTALLCKRYNIAEPFGGAMLEPEKELKAKAKISVFDYLETSV 639
            .:::..::        |....|.|..|||||:|:.:|:.|:.|.....:| :.|.|||::|  ::
  Rat   592 SDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFNVPDPYPGSTLVGLPRVK-RDKYSVFNFL--TL 653

  Fly   640 NTKANFETPSI---------------FPKHIEKSIPEKVETPPSP---------PPAPQPEAEIQ 680
            :..|:..|..:               .|...:.|..||.|...|.         .|:.|..:.:.
  Rat   654 SEPASLPTAPVPSEKAPQQRGPDKSRKPSRWDTSKQEKKEDSISEFLSQARSKVGPSKQESSALG 718

  Fly   681 DKPNTKEEPSKHTFVPKTPLEQAVDESRNKPISE-KVDLFKSIFEDSDEEETELSEQDKLAILQE 744
            .|.....||.     |...:::|||...::..|. .:||||:||..|.:|::..||:::
  Rat   719 SKEEQASEPH-----PDMTVDKAVDAQPDREGSRPSMDLFKAIFASSSDEKSSSSEEEQ------ 772

  Fly   745 SFGLPVTSTTSAAAQNVLRNTSPPRGIFASLFSPKIKDAAK----EPAPTKFGPIEGSKLKIAYK 805
                    ..|..:|......|......|::....:..||:    ||| |.| ||:    |:...
  Rat   773 --------DDSEDSQEHTEEASLKGSQEAAVGETSLIHAAEQEPGEPA-TPF-PIQ----KVQID 823

  Fly   806 PRKERLRNDRELAMAEVAPEDIYGPKLPTAPPQKPAAPEIQAEANIDDRLQQLWQQHAPKKRKAE 870
            .|:|                  :||:||..     ..|.::.:..|            |.|
  Rat   824 EREE------------------FGPRLPPV-----FCPNVRQKLEI------------PHK---- 849

  Fly   871 KWVEKKCISGSEDSDASSSNESSSSDSSDDNDKRSKLSKPKKSHKGSSSKKSKKSKLKSKKKSKK 935
                                                 .|||||.:...|||..:.|.:.|||.||
  Rat   850 -------------------------------------EKPKKSKERHRSKKEHRRKREKKKKHKK 877

  Fly   936 SEESKHKAKKKKKKSK 951
               .|||:|:|.|||:
  Rat   878 ---HKHKSKQKNKKSE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8833	NP_648669.1	DUF1604	27..112	CDD:400178	56/85 (66%)
CG8833	NP_648669.1	G-patch	154..201	CDD:396249	20/46 (43%)
Gpatch1	NP_001099716.1	DUF1604	31..116	CDD:285014	56/85 (66%)
Gpatch1	NP_001099716.1	G-patch	154..>172	CDD:279867	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353809
Domainoid	1	1.000	190	1.000	Domainoid score	I3181
eggNOG	1	0.900	-	-		E1_KOG2138
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2165
OMA	1	1.010	-	-		QHG56126
OrthoDB	1	1.010	-	-		D1175081at2759
OrthoFinder	1	1.000	-	-		FOG0005405
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103645
Panther	1	1.100	-	-	LDO	PTHR13384
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3832
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860