DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and CYTIP

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	170	Identity:	43/170 - (25%)
Similarity:	68/170 - (40%)	Gaps:	39/170 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 HYSNGGTRDRDRTGRRSPASSPPST-THQIYRDRERERDRSVPNIHEL--------TTRTVSMSR 301
            |.|||...|    ....||.|..|| |..:..|..|........:..|        .||:.|:|.
Human     9 HSSNGNLAD----FCAGPAYSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLALTRSSSLSD 69

  Fly   302 -----------DQQIDHGFGICVKGGK-------DSGLGVYISRIEENSVAERAGLRPGDTILEV 348
                       ::|.:..||..::..:       .|.:...|.:|:|:|.|..|||:.||.:..:
Human    70 FSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPAHCAGLQAGDVLANI 134

  Fly   349 NGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNST 388
            ||.......:    |:.|.:::||..: :|:.   |||.|
Human   135 NGVSTEGFTY----KQVVDLIRSSGNL-LTIE---TLNGT 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	25/103 (24%)
		PDZ_signaling	466..543	CDD:238492
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	21/89 (24%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810