DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and SLC9A3R1

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_004243.1	Gene:	SLC9A3R1 / 9368	HGNCID:	11075	Length:	358	Species:	Homo sapiens

Alignment Length:	261	Identity:	71/261 - (27%)
Similarity:	102/261 - (39%)	Gaps:	49/261 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 HGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKS 371
            :|:|..:.|.|.. ||.||..:|..|.||:|||..||.::||||.......|::.:.|....|.:
Human    22 NGYGFHLHGEKGK-LGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNA 85

  Fly   372 SRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTC 436
            .|   :.|..|.|   ...|...|...|:.:..:...|     ..|...|||...|||
Human    86 VR---LLVVDPET---DEQLQKLGVQVREELLRAQEAP-----GQAEPPAAAEVQGAG------- 132

  Fly   437 SWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGL---------GIFV 492
                    ..:.|.|......|:|:        :.|  .|..|.:|...||.         |.|:
Human   133 --------NENEPREADKSHPEQRE--------LRP--RLCTMKKGPSGYGFNLHSDKSKPGQFI 179

  Fly   493 TGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKY---HKRMSLVIRDVGKVPHSCTS 554
            ..||.||.|:.|||...|.|:||||.......|.:.|..::.   ..::.:|.|:..:....|..
Human   180 RSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRV 244

  Fly   555 I 555
            |
Human   245 I 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	25/72 (35%)
		PDZ_signaling	466..543	CDD:238492	25/88 (28%)
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
SLC9A3R1	NP_004243.1	PDZ_signaling	12..91	CDD:238492	25/72 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..192		25/107 (23%)
		PDZ_signaling	152..231	CDD:238492	24/80 (30%)
		EBP50_C	235..358	CDD:312529	2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810