DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and PDZD7

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	1184	Identity:	256/1184 - (21%)
Similarity:	375/1184 - (31%)	Gaps:	487/1184 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 MAAGTA--------GTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYH 246
            ||.|.|        |.|.:.:.:|..|.| |..|:.               |:|.:..:......
Human     1 MAQGFAVGFDPLGLGDLSSGSLSSLSSRG-HLGSDS---------------GSTATRYLLRKQQR 49

  Fly   247 YSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGI 311
            ..||..|     |.|  ||||......|....|...|.| ..||.:........|       .|.
Human    50 LLNGPPR-----GIR--ASSPMGRVILINSPIEANSDES-DIIHSVRVEKSPAGR-------LGF 99

  Fly   312 CVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQIS 376
            .|:||.:.|||:::|::||.|.||||||..||.|.||||....|.....|:|    :|.||.::.
Human   100 SVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVK----VLTSSSRLH 160

  Fly   377 MTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPF-RQTCSWMD 440
            |.||.               ..|.|                           |:.| ::..:|:|
Human   161 MMVRR---------------MGRVP---------------------------GIKFSKEKTTWVD 183

  Fly   441 RHGRP------ASPPMEYGGRRSERRDRIRRVELLIEPGQS--LGLMIRGGVEYGLGIFVTGVDK 497
            ...|.      .|.|.:     :...|.:||:..|......  ||..||||.|:||||:|:.||.
Human   184 VVNRRLVVEKCGSTPSD-----TSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDH 243

  Fly   498 DSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVP------------- 549
            ..:|:.:|:.:||::|..||..|.|::|.:||..||....:.|.|::.|:.|
Human   244 GGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLD 308

  Fly   550 --------------------HSC------------------------------------TSIEME 558
                                .||                                    |:::.|
Human   309 RLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQTE 373

  Fly   559 P--------WDAYSPTG-----------------------------------------TRAR--- 571
            |        |.:..||.                                         ||::
Human   374 PDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYL 438

  Fly   572 -------------------------------------RKGQIA---------------------- 577
                                                 |:|::|
Human   439 TLWEEKQQRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDSGSLAKTYPRL 503

  Fly   578 -------------------TMVEEKARSLLPRHH----------------FASLSYYIAEYSAKA 607
                               ...:|:.|:||....                :.|....|.:.:.:.
Human   504 DIEKAGGVGPVQKFVTWRLRRDQERGRALLSARSGSPSSQLPNVDEQVQAWESRRPLIQDLAQRL 568

  Fly   608 MTIDAFVAV-------------------LLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRE 653
            :|.|..:||                   ||.:||..||..|:.:||.:|.|.|..|:|.:|...|
Human   569 LTDDEVLAVTRHCSRYVHEGGIEDLVRPLLAILDRPEKLLLLQDIRSVVAPTDLGRFDSMVMLVE 633

  Fly   654 RDPYSVDRHRRKGDPA-----RD--------------------LPVTA-----DDLEI---IAAT 685
            .:.:...:.|....||     :|                    |||..     |:.|:   :.|.
Human   634 LEAFEALKSRAVRPPALRPARQDTPPKRHLITPVPDSRGGFYLLPVNGFPEEEDNGELRERLGAL 698

  Fly   686 GRSPSSDS------GL---------GMTVTDIYKRPALQLPHRPMSAGPI---------LHRSQP 726
            ..|||:.:      |:         ..|...|...|..|||  |::..|:         |.|..|
Human   699 KVSPSASAPRHPHKGIPPLQDVPVDAFTPLRIACTPPPQLP--PVAPRPLRPNWLLTEPLSREHP 761

  Fly   727 ASHYQTGSNQS-SSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPL---GPSQLK 787
            ......|..|| |.|.|..:.:..:.|...|                 ||....|:   .||...
Human   762 PQSQIRGRAQSRSRSRSRSRSRSSRGQGKSP-----------------GRRSPSPVPTPAPSMTN 809

  Fly   788 FRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQ 852
            .|.             |:.|:....|....:.:|.:..|          ::|.:..|.:|..:..
Human   810 GRY-------------HKPRKARPPLPRPLDGEAAKVGA----------KQGPSESGTEGTAKEA 851

  Fly   853 SMQRLSAEQNGGSTTEQTHEHNPNVVPDHRGNLH-ITVKKTKPILGIAIEGGANTK-HPLPRIIN 915
            :|:                  ||:      |.|. :|:.|.|..|||:|.||..:| .|:.:|..
Human   852 AMK------------------NPS------GELKTVTLSKMKQSLGISISGGIESKVQPMVKIEK 892

  Fly   916 IHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFAN--REKAEITFLVVEAKKSNL 978
            |...||||.:|.|:.|..::.|||..:|.:.||.....|...:.|  ||..|   |||.....:.
Human   893 IFPGGAAFLSGALQAGFELVAVDGENLEQVTHQRAVDTIRRAYRNKAREPME---LVVRVPGPSP 954

  Fly   979 EPKP---TALI--FLEAXHLLALPASDPLERQKL--EFLYEWGID----------LTETPKPMPT 1026
            .|.|   :||.  .|.|.|   |||..||:...:  .:|.|...:          |..||.|.|:
Human   955 RPSPSDSSALTDGGLPADH---LPAHQPLDAAPVPAHWLPEPPTNPQTPPTDARLLQPTPSPAPS 1016

  Fly  1027 PIPLTKAKNPPPLP 1040
            |...|....|.|.|
Human  1017 PALQTPDSKPAPSP 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	32/85 (38%)
		PDZ_signaling	466..543	CDD:238492	30/78 (38%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	27/155 (17%)
		PDZ_signaling	886..971	CDD:238492	32/88 (36%)
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492	34/90 (38%)
		PDZ_signaling	209..289	CDD:238492	31/79 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		5/56 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		0/19 (0%)
		HN_PDZD7_like	554..630	CDD:259824	20/75 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864		30/173 (17%)
		PDZ_signaling	860..948	CDD:238492	34/90 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033		28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23116
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920