DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and dlg5

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_004916076.1	Gene:	dlg5 / 779611	XenbaseID:	XB-GENE-978275	Length:	1971	Species:	Xenopus tropicalis

Alignment Length:	598	Identity:	135/598 - (22%)
Similarity:	233/598 - (38%)	Gaps:	134/598 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 VPTKGGSLPGRGSAYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHA--SSNGNKKRPISPEQVL 229
            ||....|||  .||.|.||....:...:....|.|:..|.|....|:  ||......|.||
Frog  1295 VPHGSNSLP--SSARLGSSRTERIKIPSTPRYPRSSVGSDRGSLSHSECSSPSLASPPHSP---- 1353

  Fly   230 RMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTT 294
                    .::.|||:..|..          :|..:|.|..:.......||.:||  |.:.|  .
Frog  1354 --------LNLETSSFASSQS----------QSSVASLPRISVSTVPIGERRKDR--PLVEE--P 1396

  Fly   295 RTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHE 359
            |.|.:.:..:   ..||.: ||.:|| |:::|::...|:|::|||..||.:||.||     ||..
Frog  1397 RHVKVQKGSE---PLGISI-GGGESG-GIFVSKVTTGSIAQQAGLEYGDQLLEFNG-----INLR 1451

  Fly   360 EALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLH------PQNQAAA 418
            .|.::..:::...:..::|:.|....|....:|.......|.......|  |      |.|.:..
Frog  1452 NATEQQARLIIGQQCDTITILAQYNPNMCQHIHSRSSSRLDTSTTHSTP--HSSGAATPDNHSII 1514

  Fly   419 AAAAAAASGAGLPFRQTCSWMDRHGRPASPP---MEYGGRRSERRDRIRRVELLIEPGQSLGLMI 480
            ...:....|...|       ..:...|::.|   :.......:|...:|.|.|...| :.||:.|
Frog  1515 DTVSEQDEGTMTP-------PSKESTPSTSPCSSLRTNAEGIKRHSELRVVTLSKSP-EKLGIQI 1571

  Fly   481 RGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEA-VGQLKYHKRMSLVIRD 544
            .||..:  ||||..:::::|.  .||:.||.:||.......:.|.:|| :..||..:.:.:.::.
Frog  1572 CGGNLH--GIFVLDIEEENVV--GGLLKGDMVLEYGSVDMRNRTAEEAYLEMLKPAENIKVKVQQ 1632

  Fly   545 VGKVPHSCTSIEMEPWDAYSPTGTRA--RRKGQIATMVEEKARSL------LPRHHFAS-LSYYI 600
              |: .....::..|.|.:.   .||  .|:.::.:.:..|...:      ||:..|.: :::.:
Frog  1633 --KI-DEFNKLKDLPGDGFY---IRALYDRQAELPSELSFKKDDILYVDDTLPQGTFGTWMAWQL 1691

  Fly   601 AEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEI-RELVFPEDRTRYDELV-------------YR 651
            .|.:.|           |:......|:.:..|. |.|...|.|   ||.:             :|
Frog  1692 DENAQK-----------LQRGQVPSKYMMEQEFSRRLSMSEGR---DETMASKTLSAAARRSFFR 1742

  Fly   652 RERDPYSVDRHRRKGDPARDLPVTADDLEII--AATGRSPSSDSGLGMTVTDIYK------RPAL 708
            |:      ::|:|.|  :||    ..||:.:  .:|...|..|..:.:....:.:      ||.|
Frog  1743 RK------NKHKRSG--SRD----GKDLQGLDTISTDSIPFLDESVSLAYQRVQRVDCTSPRPVL 1795

  Fly   709 QLPHRPMSAGPIL 721
            .|       ||::
Frog  1796 IL-------GPLV 1801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	25/85 (29%)
		PDZ_signaling	466..543	CDD:238492	24/77 (31%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	16/100 (16%)
		PDZ_signaling	886..971	CDD:238492
dlg5	XP_004916076.1	CARD	9..88	CDD:260018
		Takusan	127..213	CDD:368141
		Smc	<136..544	CDD:224117
		COG4372	443..>672	CDD:226809
		PDZ_signaling	697..784	CDD:238492
		PDZ_signaling	798..867	CDD:238492
		PDZ	1395..1477	CDD:214570	27/93 (29%)
		dbPDZ_assoc	1475..1554	CDD:374667	12/87 (14%)
		PDZ	1554..1633	CDD:214570	25/85 (29%)
		SH3_DLG5	1649..1711	CDD:212794	11/75 (15%)
		GuKc	1784..1960	CDD:214504	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000