DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Whrn

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	978	Identity:	277/978 - (28%)
Similarity:	406/978 - (41%)	Gaps:	253/978 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SAGVPTKGGSLPGRGSAYLSSSPAS-HMAAGTAGTLPTSTAASGRSMGQHASSN----------- 216
            ||.....||.  |.|...||::... |.|.....:.|.....:......||..|
Mouse    20 SAAAAAGGGG--GAGLRLLSANVRQLHQALTALLSEPEREQFTHCLNAYHARRNVFDLVRTLRVL 82

  Fly   217 --GNKKRPISPEQVLRMFGATQSSSVPTSSY----HYSNGGTRDRDRTGRRSPASSPPSTTHQIY 275
              ...||.:.|  :||:.       :|.|..    .|:..|......|..|.||.:.|
Mouse    83 LDSPVKRRLLP--MLRLV-------IPRSDQLLFDQYTAEGLYLPATTPYRQPAWAAP------- 131

  Fly   276 RDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLR 340
                   |.:.|.    ..|.||:.| .:...|.|..::||.:.|:|:|:|.:|..|:||:.|||
Mouse   132 -------DGAGPG----EVRLVSLRR-AKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLR 184

  Fly   341 PGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYAS 405
            .||.||.||......:.|.||:|    .||.|:::.::|                       |::
Mouse   185 VGDQILRVNDKSLARVTHAEAVK----ALKGSKKLVLSV-----------------------YSA 222

  Fly   406 MAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASP----PMEYGG----RRSERRDR 462
            ...|                  .|.......:|:|..||..||    |..:|.    |..:||..
Mouse   223 GRIP------------------GGYVTNHIYTWVDPQGRSTSPPSSLPQPHGSTLRQREDDRRST 269

  Fly   463 I--------RRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQS 519
            :        ::|.|::..|:||||.||||.||||||::||||..|.|:.|||.:||:||||||:|
Mouse   270 LHLLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLKVGDQILEVNGRS 334

  Fly   520 FLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYS-------------------- 564
            ||::.|||||..||..:.:.|.::|||::||:.|:::...|.|.|
Mouse   335 FLNILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESVANSAGFPGDHTEEG 399

  Fly   565 ---------PTG---TRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVL 617
                     |.|   |.:....|...:::::||.||.....|::.||:|:|....::::|.|..|
Mouse   400 TSKPGFYKGPAGSQVTLSSLGNQTRALLDDQARHLLTEQERATMMYYLAQYRGGTISVEAMVMAL 464

  Fly   618 LEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRE--------------RDPYSVDRHRRKG-- 666
            .|:|:|:.|.:|::|:|.::.|:|..|:|.||.|||              .|.||:..:...|
Mouse   465 FELLNTHAKFSLLSEVRSIISPQDLDRFDHLVLRREIESMKARQPPGPGVGDTYSMVSYSDTGSS 529

  Fly   667 ----------DPAR-------DLPVTADDLEIIAATGR-SPSSDSGLGMTVTDIYKRPALQL--- 710
                      ..||       ||.....|||   .||. :..|.:.|.....|..|.|:..|
Mouse   530 TGSHGTSTTVSSARERLLWLIDLMENTLDLE---GTGETTQGSTNALPDVSVDDVKSPSEDLPGI 591

  Fly   711 ----PHRPMSAGPILHRSQP-------------ASH----YQTGSNQS--SSSLSPPQQQQQQQQ 752
                |..|::.|......||             |:|    :....|:|  ..:...|.....|..
Mouse   592 KPPPPPPPLAQGHDRLLGQPRKPGREDPAPLSSAAHSGIVFSAPRNRSPPPGTAPTPGPSSAQDS 656

  Fly   753 HYQPHHASLRHLGGIGGNVGSGR----H----HHHPLGP-----SQLKFRQTKDNQQQEYGC--- 801
            ...|.:||:.|     .|..|.:    |    :.||:||     |....:...........|
Mouse   657 PSSPIYASISH-----ANPSSRKPLDTHLALVNQHPIGPFPRVQSPPHLKSPPAETPGAGACLPP 716

  Fly   802 ---DEHRTRRGS-------ETLLPEYEPDAEQELATKLSRS----FDMKEEGGTLLGDKGVRRHQ 852
               .||....|:       |...|:.|||..:..|...:|:    ..:.:.|.||..|.||...:
Mouse   717 PSPSEHPDAVGANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGE 781

  Fly   853 S--------MQRLSAEQNGGS---TTEQTHE--HNPNVVPDHRGNLHITVKKTKPILGIAIEGGA 904
            :        .|..||:...|.   .||:|.|  :.|..:.:....| :.|:|:...|||||||||
Mouse   782 TEASTSGRGRQTASAKNKNGKEQPRTERTAEGANKPPGLLEPTSTL-VRVRKSAATLGIAIEGGA 845

  Fly   905 NTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFL 969
            ||:.|||||:.|...|:|...|.|:||.:||||:|..:.|..|:|.||:|||.|..:|:..|.||
Mouse   846 NTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGQTLRGKEHKEAARIIAEAFKTKERDYIDFL 910

  Fly   970 VVE 972
            |.|
Mouse   911 VTE 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	32/85 (38%)
		PDZ_signaling	466..543	CDD:238492	45/76 (59%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	27/79 (34%)
		PDZ_signaling	886..971	CDD:238492	43/84 (51%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822	14/83 (17%)
		PDZ_signaling	139..216	CDD:238492	32/81 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		7/25 (28%)
		PDZ_signaling	278..358	CDD:238492	45/79 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		0/19 (0%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	27/79 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		58/271 (21%)
		PDZ_signaling	827..898	CDD:238492	38/71 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7703
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2899
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006185
OrthoInspector	1	1.000	-	-		oto95349
orthoMCL	1	0.900	-	-		OOG6_107411
Panther	1	1.100	-	-	O	PTHR23116
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5115
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860