DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Ush1c

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_710143.2	Gene:	Ush1c / 72088	MGIID:	1919338	Length:	910	Species:	Mus musculus

Alignment Length:	947	Identity:	189/947 - (19%)
Similarity:	311/947 - (32%)	Gaps:	351/947 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 HQIYRDRERERDRSVPNIHELTTRTVSMSRDQQID----HGFGICVKGGKDSGLGVYISRIEENS 332
            ||:..|             :||.|.....::.::|    .|.|:.|:||.:.|.|::||.:.:..
Mouse    70 HQVEYD-------------QLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGG 121

  Fly   333 VAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLH-GFGP 396
            .|:..||:.||.|:.:||...:|..|||.    :.::::.:.:|:.||           | |..|
Mouse   122 QADSVGLQVGDEIVRINGYSISSCTHEEV----INLIRTKKTVSIKVR-----------HIGLIP 171

  Fly   397 PSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSW--MDRHGRPASPPMEYGGRR--- 456
            ....|                               .::..|  :|:.      ..|.||.|
Mouse   172 VKSSP-------------------------------EESLKWQYVDQF------VSESGGVRGGL 199

  Fly   457 ---SERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQ 518
               ..|..:.::|.:.:...:.||..|..|.....||||:.|...|::...||..||:|:||||.
Mouse   200 GSPGNRTTKEKKVFISLVGSRGLGCSISSGPIQKPGIFVSHVKPGSLSAEVGLETGDQIVEVNGI 264

  Fly   519 SFLDVTHDEAVGQLKYHKRMSL-VIRDVG----------------------------KVPHSCTS 554
            .|.::.|.|||..||..:.::: ::...|                            ::......
Mouse   265 DFTNLDHKEAVNVLKSSRSLTISIVAGAGRELFMTDRERLEEARQRELQRQELLMQKRLAMESNK 329

  Fly   555 I-----EMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLS--------YYIAEYSAK 606
            |     |||          |.|||.......||..|.   |.....:|        .:..::.:|
Mouse   330 ILQEQQEME----------RQRRKEIAQKAAEENERY---RKEMEQISEEEEKFKKQWKEDWGSK 381

  Fly   607 AMTIDAFVAVLLEMLDTYEKHTL-----------------VTEIRELVFPEDRTRYDEL------ 648
            ..       ::|....|.|.|.:                 ...||:....:.:.:||.|
Mouse   382 EQ-------LILPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKKKAKYDSLQDLRKN 439

  Fly   649 ---------VYRRERDPYSVDRHRRKGDPARDLPVT-ADDLE-------------------IIAA 684
                     :|:.:.:....::..:....|:::..| .:|||                   |.:|
Mouse   440 KKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKTQYWVERLCQTRLEQISSA 504

  Fly   685 --------TGRSPSSDS-------------GLGMTVTDI--------YKRP----ALQ-LPHRP- 714
                    ||..|...|             |:.:..||:        |..|    ||. :||.|
Mouse   505 ENEIPEMTTGPPPPPPSVSPLAPPLRRFAGGIHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPS 569

  Fly   715 ------MSAGPILHRSQPASHYQTGSNQSSSS------------LSPPQQQQQQQQHYQPHHASL 761
                  :.|.|:|    |:|    |...||||            ..||....|.....:|..::|
Mouse   570 VNPPSKVPAPPVL----PSS----GHVSSSSSPWVQRTPPPIPIPPPPSIPTQDLTPTRPLPSAL 626

  Fly   762 RH-LGGIGGNVGSGRH-------HHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRG------SET 812
            .. ||......|...|       :.|...||.....:.......:..|...:..||      |:.
Mouse   627 EEALGNHPFRTGDPGHPADDWEANTHSGKPSSSPTTERSFPPAPKTFCPSPQPPRGPGVSTISKP 691

  Fly   813 LLPE------YEPDAEQEL------------ATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSA 859
            ::..      |.|..:.|:            .|...:.|...|||           .......|.
Mouse   692 VMVHQEHNFVYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEG-----------FDPYSMFSP 745

  Fly   860 EQNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRII--NIHENGAA 922
            ||..|.....                 :.:|| :..|.:|:|||.::  |:.:::  .::|.|||
Mouse   746 EQIAGKDVRL-----------------LRIKK-EGSLDLALEGGVDS--PVGKVVVSAVYEGGAA 790

  Fly   923 FEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKA--------EITFLVVEAKKSNLE 979
            ...||:..|..|:.::|..|...       .:||..|..:||        ::...|...|:.:.|
Mouse   791 ERHGGVVKGDEIMAINGKIVTDY-------TLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDE 848

  Fly   980 PKPTALIFLEAXHLLALPA----SDPLERQKLEFLYE 1012
                         |.:||:    |..|.|::|| .||
Mouse   849 -------------LSSLPSSAAESPQLARKQLE-AYE 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	24/89 (27%)
		PDZ_signaling	466..543	CDD:238492	27/77 (35%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	17/119 (14%)
		PDZ_signaling	886..971	CDD:238492	23/94 (24%)
Ush1c	NP_710143.2	N-terminal domain. /evidence=ECO:0000250\|UniProtKB:Q9Y6N9	1..86		6/28 (21%)
		harmonin_N	2..80	CDD:259819	5/22 (23%)
		PDZ_signaling	85..165	CDD:238492	23/83 (28%)
		Mediates interaction with MYO7B. /evidence=ECO:0000250\|UniProtKB:Q9Y6N9	194..833		137/704 (19%)
		PDZ_signaling	209..289	CDD:238492	27/79 (34%)
		Cgr1	<309..>358	CDD:281823	11/61 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..688		28/132 (21%)
		PDZ_signaling	751..838	CDD:238492	23/113 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	890..910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810