DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Dlg5

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	875	Identity:	182/875 - (20%)
Similarity:	301/875 - (34%)	Gaps:	237/875 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 EAEDIGMAFGMISPPPGS-GPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSYTIVERP 155
            |.::...|.|.:||.... .||....|:..|:.:........|...||    ..|||:...:.|
Mouse  1144 EEQECVPAIGELSPEGQEWSPYSPGHASRHGNPLLYPNRPSVGTVPRS----MTPGTTVGSILR- 1203

  Fly   156 HSPHYYFNSAGVPTKGGSLPGRGSAYLSSSPA-----------SHMAAGTAGTLPTSTAASGRSM 209
             :|.|...|..|...|.....|.:...|.||:           ||.|......:..|..::....
Mouse  1204 -NPIYTVRSHRVLPCGSPPVPRDAGSQSLSPSVQHQGRLSLDLSHRACSDYSEMRASQGSNSLPS 1267

  Fly   210 GQHASSNGNK-------KRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRD--RTGRRSPAS 265
            .....|:.|.       |.|::|.....:.|:.:      .|..:|...|..|.  .....|..|
Mouse  1268 SARLGSSSNLQFKAERIKIPLTPRYPRSVMGSDR------GSLSHSECSTPPRSPLNIDTLSSCS 1326

  Fly   266 SPPSTTHQIYR-------DRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGV 323
            .|.:|...:.|       ..||.:||  |.:.|  .|.|.:.:..:   ..||.:..|:..  ||
Mouse  1327 QPQTTASTLPRIAVNPSSHGERRKDR--PFVEE--PRHVKVQKGSE---PLGISIVSGEKG--GV 1382

  Fly   324 YISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEAL----KRC--VQILKS----SRQISMT 378
            |:|::...|:|.:|||..||.:||.||....|...::|.    ::|  :.||..    ..|::..
Mouse  1383 YVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHIHQLNSH 1447

  Fly   379 VRAPPTLNSTAPLHGF--GPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDR 441
            .|:...|:..|..|..  |..:..|.:.|:..||..|::           |.|.|..:
Mouse  1448 SRSSSHLDPAATPHSTLQGSSAGTPEHPSVIDPLMEQDE-----------GPGTPPAK------- 1494

  Fly   442 HGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVA-DRSG 505
              :.||.....|....:..|  .|:..:.:....||:.:.||..:  |:||..|:.||.| ...|
Mouse  1495 --QSASSTRSVGDTTKKTPD--PRIVFIKKSQLDLGVHLCGGNLH--GVFVAEVEDDSPAKGPDG 1553

  Fly   506 LMIGDEILEVNGQSFLDV----THDEAVGQLKYHKRMSLVIRDVGKVPH---SCTSIEMEPWDAY 563
            |:.||.|||...   ||:    ..|..|..||....:.|      ||.:   ..|.::..|.|::
Mouse  1554 LVPGDLILEYGS---LDMRSRTVEDVYVEMLKPKDSLRL------KVQYRHEEFTRVKGLPGDSF 1609

  Fly   564 SPTGTRA--RRKGQIATMVEEKARSL------LPRHHFAS-LSYYIAEYSAKAM--------TID 611
            .   .||  .|..::...:..|...:      ||:..|.| :::.:.|.:.|..        .:|
Mouse  1610 Y---IRALYDRLAEVEPELSFKKDDILYVDDTLPQGVFGSWMAWQLDENAQKIQRGQIPSKYVMD 1671

  Fly   612 AFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTA 676
            ...:..|.|.:..:.:|..|    |.....|:     .:||:.      :|:|.|        :.
Mouse  1672 QEFSRRLSMSEVKDDNTAKT----LSAAARRS-----FFRRKH------KHKRSG--------SK 1713

  Fly   677 DDLEIIA----ATGRSPSSDSGLGMTVTDIYK------RPALQLPHRPMSAGPIL---------- 721
            |..:::|    :....|..:..:.:....:.|      ||.|.|       ||:|
Mouse  1714 DGKDLLALDTFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLLL-------GPLLDVVKEMLVNE 1771

  Fly   722 -------------HRSQPA-----------------SHYQTGSNQSSSSLSPPQQQQQQQQH--- 753
                         ..||.|                 .|:...:..|...::      ::.:|
Mouse  1772 APGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEIT------EKNRHCLL 1830

  Fly   754 -YQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQ--LKFRQTKDNQQQE---YGCDEHRTRRGSET 812
             ..||...              |.||..:.|..  ::::..|..::|.   |..|:...|...|.
Mouse  1831 DIAPHAIE--------------RLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSKEQ 1881

  Fly   813 LLPEYEPDAEQELATKLSRSFDMKEEGGTL 842
            .      :..|::..:.||.|....:||.|
Mouse  1882 F------ETAQKIDQEYSRYFTGVVQGGAL 1905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	26/95 (27%)
		PDZ_signaling	466..543	CDD:238492	25/81 (31%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	15/94 (16%)
		PDZ_signaling	886..971	CDD:238492
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492
		PDZ_signaling	<741..800	CDD:238492
		PDZ	1357..1439	CDD:214570	26/88 (30%)
		dbPDZ_assoc	1437..1512	CDD:374667	17/94 (18%)
		PDZ	1513..1594	CDD:214570	28/91 (31%)
		SH3_DLG5	1610..1672	CDD:212794	10/64 (16%)
		GuKc	1744..1920	CDD:214504	33/195 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900