DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_075542.2	Gene:	Slc9a3r2 / 65962	MGIID:	1890662	Length:	337	Species:	Mus musculus

Alignment Length:	367	Identity:	83/367 - (22%)
Similarity:	131/367 - (35%)	Gaps:	119/367 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 IHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPF 353
            :..|..|...:.|.:|   |:|..:.|.| ...|.:|.|:|..|.||.|.||.||.::||||...
Mouse     4 LESLRPRLCRLVRGEQ---GYGFHLHGEK-GRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNV 64

  Fly   354 TSINHEEALKRCVQILKSSRQISMTVRAPP------TLNSTAPL-HGFGPPSRDPMYASMAPPLH 411
            ....|.:.::| ::.::...|:.:..:...      .|..|..: |...||:.:|.        .
Mouse    65 EGETHHQVVQR-IKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPW--------E 120

  Fly   412 PQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSL 476
            |:...|.:.:..:.:|.          .|.:|    ||.|...|....|
Mouse   121 PKPDWACSGSLGSDTGQ----------KDVNG----PPRELRPRLCHLR---------------- 155

  Fly   477 GLMIRGGVEYGL---------GIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQL 532
                ||...||.         |.::..||..|.|..|||...|.::|||||:...:.|.|.|.::
Mouse   156 ----RGPQGYGFNLHSDKSRPGQYIRSVDPGSPASHSGLRAQDRLIEVNGQNVEGLRHAEVVARI 216

  Fly   533 K-----------------YHKRMSLVIRD---VGKVPHS---------------CTSIEMEP--- 559
            |                 :.||:.::..:   .|.:|..               |:|....|
Mouse   217 KAQEDEARLLVVDPETDEHFKRLRVIPTEEHVEGPLPSPVTNGTSPAQLNGGSVCSSRSDLPGSE 281

  Fly   560 --------W--DAY-------SPTGTRARRKGQIATMVEEKA 584
                    |  |.:       |||...|:.|.: ||.|.::|
Mouse   282 KDNEDGSTWKRDPFQESGLHLSPTAAEAKEKAR-ATRVNKRA 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	26/85 (31%)
		PDZ_signaling	466..543	CDD:238492	24/102 (24%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	5/12 (42%)
		PDZ_signaling	886..971	CDD:238492
Slc9a3r2	NP_075542.2	PDZ_signaling	9..88	CDD:238492	26/83 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..147		10/56 (18%)
		PDZ	148..230	CDD:214570	24/101 (24%)
		EBP50_C	232..337	CDD:286142	18/92 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..337		16/82 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810