DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and dlg5a

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	1150	Identity:	209/1150 - (18%)
Similarity:	342/1150 - (29%)	Gaps:	459/1150 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 RDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSM--------------SRDQ 303
            |:|||      |.|..:...:...|..::|:.:...:.||..:..|.              |.|.
Zfish   625 RERDR------AVSDLADALRNLDDMRKQRNDAARELKELKEKMESQLDKEARFCQLMAHSSHDS 683

  Fly   304 QID------------------------HGFGICVKGGKDSGL----GVYISRIEENSVAERAGLR 340
            .||                        .||.| .:|..|..|    |:::||:::.|:|: ..||
Zfish   684 AIDTDSLEWETEVVEFEKDRDDMDLKAMGFDI-AEGVNDPYLPGDCGIFVSRVDKGSIAD-GRLR 746

  Fly   341 PGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYAS 405
            ..|.:|::|....|:.:.::.:|   .:|.....|:|.||...:|
Zfish   747 VNDWLLKINDVDLTNKDRKQVIK---AVLNGGGLINMVVRRRKSL-------------------- 788

  Fly   406 MAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLI 470
                                                           |||      .:..|.:.:
Zfish   789 -----------------------------------------------GGR------LVTSVHINL 800

  Fly   471 EPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSG-LMIGDEILEVNG-----------QSFLDV 523
            ...:..|:.:.|||      ||.|:...|.|.|.| |.|||.::.:||           ::.|..
Zfish   801 IGHKDAGIALEGGV------FVAGIAPGSPAAREGSLTIGDRLIAINGIALDNKSLSECEALLRG 859

  Fly   524 THDE-AVGQLKYHKRMS------------------LVIRDVGKVPHSCTSIEME-----PWDAYS 564
            ..|. |:..:|:..:.:                  :.:.||    ||..|..::     ..|.||
Zfish   860 GRDSLALSLMKFFPQSTSGQNIFESLREAEKSNGRIHLTDV----HSRNSRNLKHNSSTQTDIYS 920

  Fly   565 PTGTRARRK----GQIATMVEEKA--------RSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVL 617
            ......|||    .:.:...|.|.        .:|.|......:.|..:.:.....|....|...
Zfish   921 CDTAGERRKTRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASAFQEVCYTRSESVGPE 985

  Fly   618 LEMLDT--YEKHTLVTEIRELV----------------FPEDR-TRYDELVYRRERDPYSVDRH- 662
            ...|:|  .:||:..|..:.:|                .|:.| :.:|...::|...|...|.|
Zfish   986 CVTLETTLEKKHSGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIFDADTFKRPDTPSKADYHG 1050

  Fly   663 ----RRKGDPARDLPVT-ADDLEIIAATGRSPSSDSGL-GMTVTD---------IY--------- 703
                :....|....|.| :|..:.......|.:|:|.: .|::::         :|
Zfish  1051 PQPLKADSAPTPPTPPTRSDSFKFKHKHQGSSTSESTISAMSISEPKQEDRNGNLYFSEGKVLSS 1115

  Fly   704 -------------KRPALQLPHRPMSAGPILHRSQ-----PASHYQTGSNQSSSSLSPPQQQQQQ 750
                         :.|.::.| ||.|| |.|.|..     |...:|:.||...   |..|::..:
Zfish  1116 RKSCEEDIGRMWAEEPEVKRP-RPKSA-PALRRRMTPQNIPLQSFQSYSNDGD---SVEQREMLR 1175

  Fly   751 QQHYQPHHASLRHLGGIGGNVGSG----RHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGS- 810
            ....:||    ||..|......:|    ...|..|.|..   ..|...:...|....||....:
Zfish  1176 SSPNRPH----RHSVGFVPTSYNGTLPPNSAHRGLAPCS---AVTAVMKNPVYMVRSHRVHTNNC 1233

  Fly   811 ETLLPEY-------EPDAEQELATKLS--RSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGST 866
            .|::.:.       .|..:.:|:..||  ||.|..|...:.....|.....|..||.:..|....
Zfish  1234 PTVVSQINQQHTHPSPQHQGQLSLDLSQKRSTDYSESSRSSRASHGTNSLPSSARLGSSNNLQYR 1298

  Fly   867 TEQ-----THEHNPNVVPDHRGNL-HITVKK----TKPILGIAIE----------GGANTKHPLP 911
            ||:     |..:..:::...||:| |.....    |.|:..:.:|          |..:|   ||
Zfish  1299 TERIKIPSTPRYPRSILGSDRGSLSHSECSSPSLITPPLSPLNLETSSFASSQSQGSIST---LP 1360

  Fly   912 RI----------------------INIH-------------ENGAAF----------EAGGLEVG 931
            ||                      :.:|             |||..|          ...|||.|
Zfish  1361 RISVSPVPTEERRKDRPYLEEPRNVMVHKGAEPLGISIVSGENGGIFVSKVTGGSIAHQAGLEYG 1425

  Fly   932 QLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLEAXHLLAL 996
            ..:||.:|..:.....|: ||||
Zfish  1426 DQLLEYNGINLRNATEQQ-ARLI------------------------------------------ 1447

  Fly   997 PASDPLERQKLEFLYEWGIDLTETPKPMPTPIPLTKAKNPPPLPHELHNNINSQYGSSAALSNHQ 1061
                                                              |..|..:...::.:.
Zfish  1448 --------------------------------------------------IGQQCDTITIMAQYN 1462

  Fly  1062 PHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTGTGAAT--------TGSKQQQQPGNTTN 1118
            ||.:         |...||.:.: ......||.|| .|:|.||        |.|:|.:      .
Zfish  1463 PHMY---------QLGNHSRSSS-RLEPVSTQSTP-QGSGTATPDNHSTIDTLSEQDE------G 1510

  Fly  1119 TPTKASREATPTREQHHQHATPTREHQQQTPTRQQQLQREQQQQL 1163
            |.|.:|::.|||...:.....|: |..::.|..:....|:.|.:|
Zfish  1511 TLTPSSKQTTPTTSPNSFIRMPS-ESSKKVPEARLVTVRKTQVEL 1554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	26/127 (20%)
		PDZ_signaling	466..543	CDD:238492	22/107 (21%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	17/110 (15%)
		PDZ_signaling	886..971	CDD:238492	27/143 (19%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018
		Takusan	128..211	CDD:282652
		Taxilin	295..627	CDD:286771	1/1 (100%)
		RILP-like	338..460	CDD:304877
		SH3BP5	444..648	CDD:283045	7/28 (25%)
		PDZ_signaling	696..783	CDD:238492	21/91 (23%)
		PDZ_signaling	793..866	CDD:238492	20/78 (26%)
		PDZ	1381..1463	CDD:214570	19/174 (11%)
		dbPDZ_assoc	1461..1541	CDD:293216	24/97 (25%)
		PDZ	1541..1623	CDD:214570	2/13 (15%)
		SH3_DLG5	1639..1701	CDD:212794
		Guanylate_kin	1780..1949	CDD:279019
		NK	1794..1950	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900