DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Tamalin

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	207	Identity:	49/207 - (23%)
Similarity:	72/207 - (34%)	Gaps:	66/207 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 AAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGAT-QSSSVPTSSYHYS------ 248
            |...||..|.|.||....:            |..|.......||. :........||.:
Mouse    18 APDPAGRAPDSEAARAAPL------------PSGPPAAAAPPGAPGEELYAALEDYHPAELYRAL 70

  Fly   249 --NGGTRDRDRTGR----RSPASSPPSTTHQIYRDRERERDRSVPNIH---------ELTTRTVS 298
              :|||..| |.|.    ::...||             |:.|.|..:.         |:.|..:.
Mouse    71 AVSGGTLPR-RKGSGFRWKNFTQSP-------------EQQRKVLTLEKGDNQTFGFEIQTYGLH 121

  Fly   299 MSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALK 363
            ...:|:::              :..::.|:.|:|.|:.|||.|||||..|||.....|.|.|
Mouse   122 HREEQRVE--------------MVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHRE--- 169

  Fly   364 RCVQILKSSRQI 375
             .|.|:|:|..:
Mouse   170 -IVDIIKASGNV 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	24/82 (29%)
		PDZ_signaling	466..543	CDD:238492
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		10/43 (23%)
		PDZ_signaling	99..184	CDD:238492	26/100 (26%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810