DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and CG34375

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001163693.1	Gene:	CG34375 / 42715	FlyBaseID:	FBgn0085404	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	74/357 - (20%)
Similarity:	129/357 - (36%)	Gaps:	88/357 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   909 PLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEA 973
            |.|.:..:....:| |.||:.:|..:||::|..|.||...|:|..:.:.:  :..||:..|::..
  Fly    26 PYPWVSGVQAKSSA-ERGGVRLGDTLLELNGADVLGLKISELANRLQDHW--QSGAEVVTLMMWR 87

  Fly   974 KKSNLEPKPTALIFLEAXHLLALPASDPLERQKLEFLYEWGIDLTETPKPMPTPIPLTKAKNPPP 1038
            :::|::|....   .|| |.:    ...:.:|.|:   ::...|....:.:..|:.|...| ||.
  Fly    88 QQANIDPNEDP---AEASHAV----QHGINQQSLQ---KFATCLQHISQLLECPVCLEVIK-PPG 141

  Fly  1039 LP----HELHNNINSQY------------GSSAALSNHQPHQHTHPHP------QQQQQQQQHSN 1081
            ..    |.|.||..|:.            .....||:..........|      .:....|.|..
  Fly   142 WQCCNGHVLCNNCRSRSVKCPVCRVPLGPRGRCLLSDKLFTLLAESFPCDGGKTNKVAASQGHGK 206

  Fly  1082 TKTPNTNSNKTQGTP-----TTGTGAATTGSK--QQQQPGNTTNTPTKASREATPTREQHH---- 1135
            ..:.|..:|:....|     .|.:|.:..|.:  :|.:......:|.:..|::...:||..
  Fly   207 LSSVNKCTNEYHNQPKMALAKTSSGKSKCGKQISRQLETVLVDQSPREIRRKSQQGQEQEQAVQE 271

  Fly  1136 -----------QHATPTREHQQQ---------------------TPTRQQQLQREQQQ------Q 1162
                       ||.....||..:                     |...|..|:.::..      |
  Fly   272 AVLPRCTLIKVQHQEAAVEHFSEEGHNNMLVKPKLKLSKKSWRITGPDQDGLRCDEVATINNGVQ 336

  Fly  1163 LQREQQQQHHRDRQQHFREQREQREREYQHEH 1194
            :|.:||||   :|||...|:....|.|||:.|
  Fly   337 VQEQQQQQ---ERQQLGHEKSASSESEYQNYH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492
		PDZ_signaling	466..543	CDD:238492
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492	18/61 (30%)
CG34375	NP_001163693.1	PDZ	13..86	CDD:238080	18/62 (29%)
CG34375	NP_001163693.1	RING	129..168	CDD:238093	10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900