DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and CG15803

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	177/928 - (19%)
Similarity:	300/928 - (32%)	Gaps:	303/928 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 HGFGICVKGGKDSGLGVYISRIEENSVAERAG-LRPGDTILEVNGTPFTSINHEEALKRCVQILK 370
            :|.|..:.||:.:  ||.|..:....||||.| |:.||.:|::........:.|:.   ...:.:
  Fly    20 NGLGFILVGGRST--GVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQV---ATVLRQ 79

  Fly   371 SSRQISMTVRAP--------PTLNSTAPL--------------HGFGPPSRDPMYASMAPPLHPQ 413
            :..|:.:.|..|        .||...||:              |.|    ::|.:|:.|
  Fly    80 TGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLF----QNPSFATAA------ 134

  Fly   414 NQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPGQSLGL 478
              .|||||||||:|:|       |..|..|         ||              :::....:||
  Fly   135 --VAAAAAAAAAAGSG-------SDGDVGG---------GG--------------VLDVASLVGL 167

  Fly   479 MIRGGVEYGLGIFVTG-------VDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHK 536
             :|||...|..:....       :....:::.:|.:....:..:.|.....:..|...|| :...
  Fly   168 -VRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQ-RPCP 230

  Fly   537 RMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRAR----RKGQIATMVEEKARSLLPRHHFASLS 597
            |:.|.|     ||.|..|....|.....|..|:.|    :...|.|::.:..|.||......|.|
  Fly   231 RLDLDI-----VPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSAS 290

  Fly   598 YYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRH 662
                  ::.:.:.|::       :|:.|..|.|.|:.:.|:....|....:....:.....| :.
  Fly   291 ------ASGSGSPDSY-------MDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFV-KS 341

  Fly   663 RRKGDPARDLPVTADDLE----IIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILH- 722
            ..:|..|.    |:..::    |:|..|||.|     |:|     ...|::|..   :...::|
  Fly   342 IIEGSAAE----TSGQIQINDRIVAVDGRSLS-----GVT-----NHQAVELLR---NTDIVVHL 389

  Fly   723 ------RSQPASHYQTGSNQSSSSLSP-------PQQQQQQQQHYQPHHASLRHLGGIGGNVGSG 774
                  |.:...|.|....:...:.:|       .:.|.|:.|...|...|:..|..
  Fly   390 TLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSW-------- 446

  Fly   775 RHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEY-----------EPDAEQELATK 828
                  |.|..|             ..|...| .|.|.:..||           |..:...:.:.
  Fly   447 ------LPPKSL-------------DADSIAT-EGDEAVDAEYVGISGAEDEFIELPSRDTVESN 491

  Fly   829 LSRSFDMKEEGGTLLGDKGVRRHQSMQRLS-------AEQNGGSTTEQTHEHNPNVVPDHRGNLH 886
            :|...|..:..|.|..|: |.|...:..|:       |:.:|..|.||..|.........:|:..
  Fly   492 MSHVLDRSDHSGGLTKDQ-VPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKP 555

  Fly   887 IT--------------------------------VKKTKPI----------LGIAIEGGANT--- 906
            .|                                ||...|.          |||::||..:.
  Fly   556 ETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECG 620

  Fly   907 --KHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFL 969
              |.|...|.:|..:|.....|.|..|..:|:|:..|::||.|.||.:::.|.
  Fly   621 IEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKEL------------ 673

  Fly   970 VVEAKKSNLEPKPTALIFLEAXHLLALPASDPLERQKLEFLYEWGIDLTETPKPMPTPIPLTKAK 1034
                      |....|:.... |:.::                  |:.::.|:...|       :
  Fly   674 ----------PARVKLVCARGTHVPSV------------------INTSQNPEAFET-------R 703

  Fly  1035 NPPPLPHELHNNINSQYGSSAALSNHQPHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTG 1099
            :..|..|:...|:.|                         :.|..|:..|.:|.:....|....|
  Fly   704 SLLPGGHQSLQNLLS-------------------------KAQSESSLYTSSTATLTDAGAAAGG 743

  Fly  1100 TGAATTGSKQQQQPGNTT 1117
            :|....|..:.:...|.:
  Fly   744 SGGTAGGGARSKSLENVS 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	18/73 (25%)
		PDZ_signaling	466..543	CDD:238492	13/83 (16%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	15/79 (19%)
		PDZ_signaling	886..971	CDD:238492	26/131 (20%)
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	18/73 (25%)
		PDZ	307..393	CDD:214570	20/103 (19%)
		PDZ_signaling	605..680	CDD:238492	23/96 (24%)
		PDZ	773..858	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900