DRSC/TRiP Functional Genomics Resources

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Protein Alignment dysc and GRID2IP

DIOPT Version :9

Sequence 1:NP_001261810.1 Gene:dysc / 39533 FlyBaseID:FBgn0264006 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:945 Identity:181/945 - (19%)
Similarity:290/945 - (30%) Gaps:336/945 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 TTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSIN 357
            ||.|.:.::....|.||.:   ||  || ..::..:.:.|.|...||||||.||||.|.....::
Human     3 TTATPATNQGWPEDFGFRL---GG--SG-PCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLS 61

  Fly   358 HEEAL---KRCVQILKSSRQISMTVRAPPTLN-STAPLHGFGPPS--RDPMYASMAP-------- 408
            .|..:   :||             .|.||:|. ..||..|.||.|  ..|.....||        
Human    62 RERLVRLARRC-------------PRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLAL 113

  Fly   409 --------------PLH-----------------------PQNQAAAAAAAAAAS---------- 426
                          .:|                       .:.|..||....||.          
Human   114 GRELLRLAGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTL 178

  Fly   427 GAGLPFRQTCSWM---------DRH-------------GRPASPPMEYGGRR------SERRDRI 463
            ...|| |:.|..:         .:|             |:........|.:|      .||.:|:
Human   179 TLALP-REACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERL 242

  Fly   464 ------------------RRVELLI----EPG------------QSLGLMIRGGVEYGLGIFVTG 494
                              ||..||:    .||            :|.|..:||   :| .:::..
Human   243 LVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRG---HG-PVWIES 303

  Fly   495 VDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEME- 558
            |...|.||.:.|..||.||.:||....:.:||:.|..|:....|..::.:.|.||.:..|..:: 
Human   304 VLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDS 368

  Fly   559 ----------PWDA-YSPTGTRARRKGQIATMVEEKARSLLPRHHF----ASLSYYIAEYSAKAM 608
                      .|.| ..|:..|.:.:    |..::....|.|...:    |..|::      :..
Human   369 PNPSSALTSLQWVAEILPSSIRVQGR----TFSQQLEHLLTPPERYGVCRALESFF------QHR 423

  Fly   609 TIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLP 673
            .||..:..:..:|||..|..|...|.:|:      .|:|....:|:....:.......:|..:| 
Human   424 NIDTLIVDVYPVLDTPAKQVLWQFIYQLL------TYEEQELCQEKIACFLGYTAMTAEPEPEL- 481

  Fly   674 VTADDLE-----------------IIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPIL 721
                |||                 :...:.||...::||....::.   |.:.||..|       
Human   482 ----DLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSEC---PEMPLPLIP------- 532

  Fly   722 HRSQPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGS-GRHHHHPLGPSQ 785
                       |..|:....|.|:....:...........|......|.:|: .:....|.|||.
Human   533 -----------GERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSP 586

  Fly   786 LKFRQTKDNQQQEYGCDEHRTRRG----SETLLPE--YEPDAEQELATKLSRSFDMKEEGGTLLG 844
            ..             ....||..|    ||.|||.  |.|.....||:.                
Human   587 AV-------------TTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASP---------------- 622

  Fly   845 DKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPN-----VVPDHRGNLHITVKKTKPILGIAIEGGA 904
                        .|:|.:..::.:.:...:|.     :.||...:...|...::..|       .
Human   623 ------------SSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRRKL-------F 668

  Fly   905 NTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVA-------------RLIAE 956
            ...||    :...:.....:....::|..:..||........::|::             ...::
Human   669 TFSHP----VRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASD 729

  Fly   957 CFANREKAEITFLVVEAKKSNLEPKPTALIFLEAXHLLALPASDPL--------------ERQKL 1007
            |.::.|  |.:.|...:...::.|.|           |:.|...||              .|...
Human   730 CISSSE--EGSSLTYSSISDHIPPPP-----------LSPPPPPPLPFHDAKPSSRSSDGSRGPA 781

  Fly  1008 EFLYEWGIDLTET--PKPMPTPIPLTKAKNPPPLP 1040
            :.|.:   .||:.  |.|.|.|.||     |||:|
Human   782 QALAK---PLTQLSHPVPPPPPPPL-----PPPVP 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dyscNP_001261810.1 PDZ_signaling 294..380 CDD:238492 25/88 (28%)
PDZ_signaling 466..543 CDD:238492 25/92 (27%)
HN_L-whirlin_R2_like 573..653 CDD:259823 16/83 (19%)
PDZ_signaling 886..971 CDD:238492 12/97 (12%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492 23/78 (29%)
HN_L-delphilin-R1_like 133..212 CDD:259820 10/79 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269 9/42 (21%)
PDZ_signaling 278..353 CDD:238492 21/78 (27%)
HN_L-delphilin-R2_like 389..468 CDD:259821 18/94 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 7/41 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 9/88 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 11/77 (14%)
FH2 820..1188 CDD:280362
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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