DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Lnx1

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	98/452 - (21%)
Similarity:	159/452 - (35%)	Gaps:	145/452 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 PGRGS-AYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSS 238
            ||..: ||.||     :..|...|.|:.|   ||       ||..:.||.            :.|
  Rat   181 PGLDNPAYTSS-----VEDGEPVTNPSDT---GR-------SNRTRARPF------------ERS 218

  Fly   239 SVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNI-----HELTTRTVS 298
            ::.:.|:...|.......||      .|..:..:...:.|:...:.:||.:     |.:....::
  Rat   219 TMRSRSFKKINRALSALRRT------KSGSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEIT 277

  Fly   299 MSRDQQIDHGFGICVK--GGKDSGL-GVYISRIEENSVAERAG-LRPGDTILEVNGTPFTSINHE 359
            ..:..::|....:.::  ||.::.| .:.|..|..:.|..|.| |.|||.||:|||...:::.|.
  Rat   278 SIKINRVDPNESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 342

  Fly   360 EA---LKRCVQILKSS--RQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAA 419
            .|   |::..|:|:.:  |:.....|:    |:.|| ..:||  ||..:..:.....|:.|....
  Rat   343 YAVRLLRQPCQVLRLTVLREQKFRSRS----NAPAP-DSYGP--RDDSFHVILNKSSPEEQLGIK 400

  Fly   420 AAAAAASGAGLPFRQTCSWM-DRHGRPASPPMEYGGRRSERRDRI-------------------- 463
            ............|......: ||||            :.|..||:
  Rat   401 LVRRVDEPGVFIFNVLNGGVADRHG------------QLEENDRVLAINGHDLRFGSPESAAHLI 453

  Fly   464 ----RRVELLI-------------------------------------------------EPGQS 475
                |||.|::                                                 :|.:|
  Rat   454 QASERRVHLVVSRQVRQPSPDIFQEAGCISNGQQSPVSGERSTSSKPAATCHEKVVSVQKDPNES 518

  Fly   476 LGLMIRGGV---EYGLGIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDVTHDEAVGQLK 533
            ||:.:.||.   |:.|.|:|..|:...|..|.| :..||.:|.|||....:|:..|||..||
  Rat   519 LGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	24/94 (26%)
		PDZ_signaling	466..543	CDD:238492	28/121 (23%)
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	27/103 (26%)
		PDZ_signaling	276..360	CDD:238492	23/83 (28%)
		PDZ_signaling	384..464	CDD:238492	14/91 (15%)
		PDZ_signaling	506..589	CDD:238492	26/75 (35%)
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900