DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and CG43707

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001260005.1	Gene:	CG43707 / 33601	FlyBaseID:	FBgn0263846	Length:	2021	Species:	Drosophila melanogaster

Alignment Length:	1032	Identity:	197/1032 - (19%)
Similarity:	309/1032 - (29%)	Gaps:	385/1032 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PPGTSYTIVERPHSPHYYFNSAGVPTKGGSLPGRGSA-----YLSSSPASHMAAGTAGTLPTSTA 203
            ||..:.|    |.:.....:....|....|:..|||.     .:.:|.|:......|..||...|
  Fly   960 PPAIAVT----PSTNQILDSCISSPLPKRSMVARGSVPDARQLMFTSGATKQRHSDASFLPMGAA 1020

  Fly   204 ASGRS---------MGQHASSNGNKKR-PISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRT 258
            ...||         ..::|:.....|| |:|          ||||.:             ::...
  Fly  1021 DYARSADISECSTNTDEYATCTDTSKRTPVS----------TQSSQL-------------EKTHA 1062

  Fly   259 GRR-SPASSPPSTTHQIYRDRERERDRS-----------VPNIHELTTRTVSMSRDQQIDHG--- 308
            |.. ..|||..|....:.:..|:|||:.           :.::.|||.::.|.|.......|
  Fly  1063 GSSFESASSLYSMREDLLQHDEKERDKQTTLTKAQLKSPIGSVAELTRKSPSHSISSTTSSGSCP 1127

  Fly   309 -FGICVKGGKDSGLGVYI-----SRIEENSVA----------------ERAGLR---------PG 342
             .|..:|......|...:     |:::.:||.                ||:.:|         |.
  Fly  1128 VLGAAIKSPAKESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPH 1192

  Fly   343 DTILEVNGTPFTS--INHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYAS 405
            :...|..||...:  :..|:..||        |:.||.:..                .::.|.|.
  Fly  1193 EEDDEEQGTRSKARRLRQEDERKR--------RKTSMKLDI----------------EKENMRAL 1233

  Fly   406 MAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPAS-----PPMEYGGRRSERRD---- 461
            .:|...|...:...:...:.||.          ||....|:.     |.:....|:|.|.|
  Fly  1234 TSPIKKPTGSSKITSPEQSISGT----------MDNGSSPSKMKRFRPKIRRQLRKSSREDVLAA 1288

  Fly   462 -RIRR----------------VELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIG 509
             .:||                .|||::...|.|.:  .|.....   ||.|...|.|.:
  Fly  1289 AAVRRSRATPTIFGLSSGSGDTELLLDASMSTGAV--AGTTTSA---VTSVSAPSSASK------ 1342

  Fly   510 DEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSP-----TGTR 569
               |..:..|.  .|..|||           |.....|.||||.:    |....||     :||:
  Fly  1343 ---LPTSESSV--TTQPEAV-----------VAPLPAKKPHSCAT----PTSLLSPKLPTTSGTQ 1387

  Fly   570 ARRKG---QIATMVEEKARSLLPRHHFASLSYYIAEYSAKAM---------------------TI 610
            ::...   |:.....|..||:.|    .|.|.:.:|....|.                     ||
  Fly  1388 SKSTSDTFQLKAKSIESLRSVSP----GSDSVFYSEADGNAASGEQSHCHHCGKEMEGKQQSNTI 1448

  Fly   611 DAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVT 675
            .......:|.: .|.:..:|....:.......|:..:.:|:: .|.......|..|:..|.....
  Fly  1449 SELAGDSVESI-PYIEQDIVKPPSDFADSPVTTKTTQRLYKK-MDKRFRSEERYHGERGRHYKTR 1511

  Fly   676 ADDLEIIAATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSS 740
            .:::       |:.|.:.|              ::|..|.:  |:|   :||         .||.
  Fly  1512 QENI-------RAKSEERG--------------RIPSLPNT--PVL---RPA---------GSSP 1541

  Fly   741 LSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDN--QQQEYGC-D 802
            ...|..:|.|...|:.|:             .:||:           .|.|.|:  .|.::.| |
  Fly  1542 CVLPDTEQSQHIIYKGHY-------------DAGRY-----------TRLTDDDLWTQLDHQCFD 1582

  Fly   803 EHRTRRGSETLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTT 867
            ..|.||.|                |:..:.|..|.:         |..|:.:||       ..|.
  Fly  1583 RSRERRAS----------------TESEKGFHAKYQ---------VILHRLVQR-------RCTL 1615

  Fly   868 EQTH--EHN----------------------------------PNVVPD---------------- 880
            |..|  :||                                  .|..||
  Fly  1616 EMYHRQKHNSFLWAKCKEISAKSFRNIFAVFTQYSGQMIELIASNSTPDSIRRKLEEVLKLMLLV 1680

  Fly   881 ---------------HRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEV 930
                           |..:..:.||......|..|.|..      |.::...|.....|:.||||
  Fly  1681 WARESYVISKLSNGAHGVDKTVVVKSDSGEFGFRIHGSK------PVVVAAIEPETPAESSGLEV 1739

  Fly   931 GQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIF 987
            |.:|:.|:|.:|...||.||.: ||.....:.:.::...:.......||| |:..||
  Fly  1740 GDIIISVNGVQVLDKHHTEVVK-IAHDGCEKLELQVARTIGVLMHEQLEP-PSQPIF 1794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	22/121 (18%)
		PDZ_signaling	466..543	CDD:238492	18/76 (24%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	16/103 (16%)
		PDZ_signaling	886..971	CDD:238492	23/84 (27%)
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	98/494 (20%)
		PDZ_signaling	1702..1775	CDD:238492	23/79 (29%)
		PH	1792..1894	CDD:278594	2/3 (67%)
		PH-like	1792..1893	CDD:302622	2/3 (67%)
		PH-like	1911..2011	CDD:302622
		PH	1921..2014	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900