DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and Whrn

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_038965801.1	Gene:	Whrn / 313255	RGDID:	631330	Length:	969	Species:	Rattus norvegicus

Alignment Length:	1036	Identity:	276/1036 - (26%)
Similarity:	406/1036 - (39%)	Gaps:	318/1036 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SAGVPTKGGSLPGRGSAYLSSSPAS-HMAAGTAGTLPTSTAASGRSMGQHASSN----------- 216
            ||.....||.  |.|...||::... |.|.....:.|.....:......||..|
  Rat    20 SAAAAAGGGG--GAGLRLLSANVRQLHQALTALLSEPEREQFTHCLNAYHARRNVFDLVRTLRVL 82

  Fly   217 --GNKKRPISPEQVLRMFGATQSSSVPTSSY----HYSNGGTRDRDRTGRRSPASSPPSTTHQIY 275
              ...||.:.|  :||:.       :|.|..    .|:..|......|..|.||.:.|
  Rat    83 LDSPVKRRLLP--MLRLV-------IPRSDQLLFDQYTAEGLYLPATTPYRQPAWAAP------- 131

  Fly   276 RDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAERAGLR 340
                   |.:.|.    ..|.||:.| .:...|.|..::||.:.|:|:|:|.:|..|:||:.|||
  Rat   132 -------DGAGPG----EVRLVSLRR-AKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLR 184

  Fly   341 PGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYAS 405
            .||.||.||......:.|.||:|    .||.|:::.::|                       |::
  Rat   185 VGDQILRVNDKSLARVTHAEAVK----ALKGSKKLVLSV-----------------------YSA 222

  Fly   406 MAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPP--MEYGG----RRSERRDRI- 463
            ...|                  .|.......:|:|..||..|||  :.:|.    ...:||..:
  Rat   223 GRIP------------------GGYVTNHIYTWVDPQGRSTSPPSSLPHGSTLRQHEDDRRSALH 269

  Fly   464 -------RRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFL 521
                   ::|.|::..|:||||.||||.||||||::||||..|.|:.|||.:||:||||||:|||
  Rat   270 LLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLKVGDQILEVNGRSFL 334

  Fly   522 DVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYS---------------------- 564
            .:.|||||..||..:.:.|.::|||::||:.|:::...|.|.|
  Rat   335 SILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESITNSAGFPGDLTEEGTN 399

  Fly   565 -------PTG---TRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLE 619
                   |.|   |.:....|...:::::||.||.....|::.||:.:|....::::|.|..|.|
  Rat   400 KPGFYKGPAGSQVTLSSLGNQTRALLDDQARHLLTEQERATMMYYLDQYRGGTISVEALVMALFE 464

  Fly   620 MLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRE--------------RDPYSVDRHRRKG---- 666
            :|:|:.|.:|::|:|.::.|:|..|:|.||.|||              .|.||:..:...|
  Rat   465 LLNTHAKFSLLSEVRGIISPQDLDRFDHLVLRREIESMKARQPPGPGVGDTYSMVSYSDTGSSTG 529

  Fly   667 --------DPAR-------DLPVTADDLEIIAATGR-SPSSDSGLGMTVTDIYKRPALQL----- 710
                    ..||       ||.....|||   .||. :..|.:.|.....|..:.|:..|
  Rat   530 SHGTSTTVSSARERLLWLIDLMENTLDLE---GTGETTQGSTNALPDVSVDDVRSPSEDLPGIKP 591

  Fly   711 --PHRPMSAG----------PILHRSQP---ASH----YQTGSNQS---SSSLSP---PQQQQQQ 750
              |..|::.|          |:...|.|   |:|    :....|:|   ...::|   |.....:
  Rat   592 PPPPPPLAQGHDRLLGQTRKPVREDSAPLSSAAHSGIVFSAPRNRSPPPPPGIAPTPTPGPSSAR 656

  Fly   751 QQHYQPHHASLRHLGGIGGNVGSGR----H----HHHPLGPSQLKFRQT------KDNQQQEYGC 801
            .....|.:||:.|     .|..|.:    |    :.||:||    |.:.      |....:..|.
  Rat   657 DSPSSPIYASISH-----ANPSSRKPLDTHLALVNQHPIGP----FPRVQSPPHLKSPPAEAPGA 712

  Fly   802 ---------DEHRTRRGS-------ETLLPEYEPDAEQELATKLSRS----FDMKEEGGTLLGDK 846
                     .||....|:       |...|:.|||..:..|...:|:    ..:.:.|.||..|.
  Rat   713 GAGLPPPSPSEHADAVGANQHFVLVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDS 777

  Fly   847 GVRRHQSMQRLSAEQNG-GSTTEQTHEHNPNVVPDHR----------GNLH-----ITVKKTKPI 895
            ||...::    .|..:| |..|..|...|...:|...          |.|.     |.|:|:...
  Rat   778 GVDAGET----EASTSGRGRQTANTKNKNGKELPQTERTTEGANKPPGLLEPTSTLIRVRKSAAT 838

  Fly   896 LGIAIEGGANTKHPLPRIINI-------------------------------------------- 916
            |||||||||||:.|||||:.|
  Rat   839 LGIAIEGGANTRQPLPRIVTIQICLPRRDTEPRDRHGQAPLHAPTLPGLWTRDWQHPARYPRDPC 903

  Fly   917 -----HENGAAFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVE 972
                 ...|:|...|.|:||.:||||:|..:.|..|:|.||:|||.|..:|:..|.|||.|
  Rat   904 LCLPVQRGGSAHNCGQLKVGHVILEVNGQTLRGKEHREAARVIAEAFKTKERDYIDFLVTE 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	32/85 (38%)
		PDZ_signaling	466..543	CDD:238492	45/76 (59%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	26/79 (33%)
		PDZ_signaling	886..971	CDD:238492	44/138 (32%)
Whrn	XP_038965801.1	HN_L-whirlin_R1_like	38..113	CDD:259822	14/83 (17%)
		PDZ_signaling	139..216	CDD:238492	32/81 (40%)
		PDZ_signaling	276..356	CDD:238492	45/79 (57%)
		HN_L-whirlin_R2_like	418..498	CDD:259823	26/79 (33%)
		PDZ_signaling	<908..949	CDD:238492	18/40 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7556
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2557
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	1	1.000	-	-		FOG0006185
OrthoInspector	1	1.000	-	-		oto98836
orthoMCL	1	0.900	-	-		OOG6_107411
Panther	1	1.100	-	-	O	PTHR23116
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5115
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870