DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and PsGEF

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	1634	Identity:	288/1634 - (17%)
Similarity:	460/1634 - (28%)	Gaps:	659/1634 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAE-----DIGMAFGM- 102
            |..::.||....|....|.::||:.:            ||.:.|.:..||.     |:.:||..
  Fly   232 AKRSSLASPTTTPPSHCTTTTSSISS------------SSSSNGGADMEASQRGSIDVSIAFDAK 284

  Fly   103 -------------ISPPPGSG-----PYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSY 149
                         :....|||     .|| ..|.:||::.       .|.||.|.......|...
  Fly   285 EQQLNVHVIRCRDLQRSHGSGNGSINAYV-KVALSGGAQP-------PGYGGHSSGGSMSSGYQR 341

  Fly   150 TIVERPHSPHYYFN-------SAGVPTKG--------------GSLP------------------ 175
            |.|.| ||...||:       |:|..|.|              .|:|
  Fly   342 TAVHR-HSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRT 405

  Fly   176 -------------GRGSAYLSSS---------PASHMAAGT------AGTLPTS-----TAASGR 207
                         .:.|.:|..|         |.|.::||:      |...|||     .|.:|:
  Fly   406 AERLAKLENAGNEAKRSEFLGCSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQ 470

  Fly   208 SMGQ--HASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGT---RDR------DRTGRR 261
            ...|  .|:.:.:|::..||.::......|....|.|.|...||...   .|.      |..|:.
  Fly   471 DQKQETEAAKDQDKQQDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKE 535

  Fly   262 SP-------------------------------ASSPP------STTHQIYR--DRERERDRSVP 287
            .|                               ...||      |||.|...  .:......:..
  Fly   536 DPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANES 600

  Fly   288 NIHELTTRTVSMSRDQQIDHGFGICVKGG-------------------KDSGLGVYI-------- 325
            |.:.|...|....|...:.:..|..|.|.                   ::.|.|..|
  Fly   601 NANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRV 665

  Fly   326 SRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVR-------APP 383
            .:||....|:|.|:.|||.::.|:.....::...:.|.     |..|:..|:|:.       ...
  Fly   666 EKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLN-----LIRSQGSSLTLEIFRRSGAGAT 725

  Fly   384 TLNST----APLH---------GFGPPSR-----------------------DPMYASMAPPLHP 412
            |:.||    ..:|         |.|....                       .|:..||:.|
  Fly   726 TITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTRIQPLANSMSRP--- 787

  Fly   413 QNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRS--ERRDRIRRVEL-LIEPGQ 474
                     |.|.||       |.|.::...|....|.....:.|  ...|..||..| ||...|
  Fly   788 ---------ATACSG-------TTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQ 836

  Fly   475 SLGLMIRGGVEYGLGIFV--TGVDKDSVADRSG----------LMIGDEILEVNGQSFLDVTHDE 527
            :    ....:.:|:..||  .|..||.::....          |.|.::|||    ........:
  Fly   837 N----FTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILE----QLCSSDQQD 893

  Fly   528 AVGQLKYHKRMSLVIRDVGKVPHSCTSIE-----MEPWDAYSPTGTRARRKGQIATMVE----EK 583
            ...|:.:..|:.|     .|....|.:.:     ::..|......:|......||.:.|    .|
  Fly   894 QEPQMNFASRVYL-----SKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRK 953

  Fly   584 ARSLL-----PRHHFASLSYYIAEYSAKAMTIDA-----FVAVLLEMLDTYEK------------ 626
            ...|.     |..||..: ..:.:..|....:|.     |..|:.|:...|.:
  Fly   954 RPDLTMFIHRPLQHFREI-LKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITVSSGLMEPLG 1017

  Fly   627 ----------------------HTLVTEIRELVFPEDRTRYDELVYRRERDPY------------ 657
                                  .||..:.|:.:|..|.:|    |..|...||
  Fly  1018 EGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSR----VEGRSVKPYWTLLFSDIIVFA 1078

  Fly   658 --SVDR-------------------HRRKGDPARDLPVTADDLEIIAATGRSPSSDSGL---GMT 698
              |.||                   |.||  ...:..:|.|      ..||...|.:|.   .:|
  Fly  1079 KVSRDRVLFITEEPIPIANVVDSCFHMRK--KTTEFRLTVD------PNGRLAESPTGYCAPDLT 1135

  Fly   699 VTD---------IYKRPALQLP-----------------------HRPMSAGPILHRSQPASHY- 730
            .|.         |.:.|:|:|.                       ..|:.:..:|:...|.|..
  Fly  1136 RTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIG 1200

  Fly   731 ----QTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLG--------- 782
                ..||.:..|..|...:|||:||.....|..:....|:..:..:.|.|.|..|
  Fly  1201 LTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSATGVATDRTADRSHGHNHGIHGGHVEQI 1265

  Fly   783 ------------------------PSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPE-----YE 818
                                    .:.:|.:..|..||.....    ..|..|.:..|     :.
  Fly  1266 ELLIDEKCRILNKTGTPKSSALHLANWMKGQLDKQQQQARLAA----IARSQENVSAEDEQLIFN 1326

  Fly   819 PDAEQ---------ELATKLSRSFDMKEEGGTLLG--DKGVRRHQSMQRLS----------AEQN 862
            .|:||         :...|.::..::.:|.|.|..  :.|.:|...::.||          :|..
  Fly  1327 SDSEQDERITYWTRQQLEKRTKELNLAKENGGLSARPNFGGKRLSGVEELSMSATSDIYSTSEAE 1391

  Fly   863 G-GSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILG-IAI--------------------EGGAN 905
            | .|...|:|...        .:..|||:.:..:|. :|:                    .||.|
  Fly  1392 GVTSVISQSHSTT--------SDSQITVRSSPIVLDKLAVCRHCHKNCQQSGPGGARPGGGGGVN 1448

  Fly   906 TKHPLPRII---------------------------------NIHENGAAFEAGGL--------- 928
            .....|.::                                 |.:..|..  .|.:
  Fly  1449 NSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMANPKNSNRTGTG--TGSVTSMSSSTIT 1511

  Fly   929 -EVGQLILEVDGTKVEGLHHQEVARLIAECF-----------------ANREKAEITFLVVEAKK 975
             |:...::.....:..|....:||:||.:..                 ::|...|...::..::.
  Fly  1512 GELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRL 1576

  Fly   976 SNLEPKPTALIFLEAXHLLALPASDPLERQKLEFLYEWGIDLTETPKPMPTP----IPLTKAKNP 1036
            .:|:| |.::..|.. |..|                  |:. ..:|||:|.|    :.....:.|
  Fly  1577 RHLDP-PVSVSSLPNGHCSA------------------GVG-GGSPKPLPPPRRTRVVAQMCQEP 1621

  Fly  1037 PPLPHELHNNINSQYGSSAALSNHQPHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTGTG 1101
                                           |.|:..||.:.   ..|....:...:.:||.|:|
  Fly  1622 -------------------------------PRPKANQQVKA---IVTITETARIMRSSPTKGSG 1652

  Fly  1102 A-ATTGSKQQQQPGNTTNTPTKASR---EATPTREQHHQHATPTREHQ--------QQTPTRQQQ 1154
            : :.||:      |:...:|.|.:.   ..||....|.|.:....|||        :||.|..:|
  Fly  1653 SGSATGT------GSVGGSPAKYAACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQ 1711

  Fly  1155 LQREQQQQL 1163
            .|.::|..|
  Fly  1712 KQEDEQLSL 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	22/112 (20%)
		PDZ_signaling	466..543	CDD:238492	18/89 (20%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	21/127 (17%)
		PDZ_signaling	886..971	CDD:238492	20/165 (12%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593	24/103 (23%)
		PDZ_signaling	644..716	CDD:238492	17/76 (22%)
		RhoGEF	831..1000	CDD:295373	34/182 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900