DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dysc and PDZD2

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	1256	Identity:	269/1256 - (21%)
Similarity:	392/1256 - (31%)	Gaps:	430/1256 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SFGLGPSMGGTQSS---------SSVPTGGSAG-------------LSGHHLRSSGAPGPSSFEA 93
            |.|||..:.|.:.|         :.|..||:|.             ::||.|     .|.|..||
Human   341 SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL-----VGLSHEEA 400

  Fly    94 EDI-----GMAFGMISPPPGSG-----------PYVGSSAAAGGSRVGNSTSSLRG---AGGRSG 139
            ..|     ||...:::....|.           |.:.||.....|...|......|   .|..|.
Human   401 VAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSS 465

  Fly   140 LYYSPPGTSYTIVERPHSPHYYFNSAGVPTKGGSL--PGRGSAYLSSSPASHMAAGTAGTLPTST 202
            :..:.|||     :.|.      :..|.....|:|  |.:||..:...  |.::.|      ...
Human   466 VQRAMPGT-----DEPQ------DVCGAEESKGNLESPKQGSNKIKLK--SRLSGG------VHR 511

  Fly   203 AASGRSMGQHASSNGNKK----------RPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDR 257
            ..|.....:....||:.:          |..|..|:|       .||..:..||.....||....
Human   512 LESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLL-------DSSSASQEYHIVKKSTRSLST 569

  Fly   258 TGRRSP-ASSPPSTTHQI--YRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKD- 318
            |...|| ....||....|  |:::.:                           |.|..:.||:|
Human   570 TQVESPWRLIRPSVISIIGLYKEKGK---------------------------GLGFSIAGGRDC 607

  Fly   319 --SGLGVYISRIEEN-SVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVR 380
              ..:|:::..|..| |.||...|:.||.||:|||.|...:..:||:....||  .|....:|||
Human   608 IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI--RSGLFVLTVR 670

  Fly   381 ----APPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDR 441
                :|.....:.|.|         |..|.:|..   |.:..|:|..:..|:....
Human   671 TKLVSPSLTPCSTPTH---------MSRSASPNF---NTSGGASAGGSDEGSSSSL--------- 714

  Fly   442 HGRPASPPMEYGGRRSERRDRI-RRVELLIEPGQSLGLMIRGGVEYGL-----GIFVTGVDKDSV 500
             ||....|          :||| ..|.|..||...||:   |.....|     ||::..:...||
Human   715 -GRKTPGP----------KDRIVMEVTLNKEPRVGLGI---GACCLALENSPPGIYIHSLAPGSV 765

  Fly   501 AD-RSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYS 564
            |. .|.|..||:|||||.   ::|.|   ....|.|..:|           .|
Human   766 AKMESNLSRGDQILEVNS---VNVRH---AALSKVHAILS-----------KC------------ 801

  Fly   565 PTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTL 629
            |.|               ..|.::.||....:|         ...:|..:|     ..||::...
Human   802 PPG---------------PVRLVIGRHPNPKVS---------EQEMDEVIA-----RSTYQESKE 837

  Fly   630 VTEIRELVFP---EDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPVTADDLEIIAATGRSPSS 691
            ......|..|   ....:.|.|:...|...|..  |...| |..|..|...:.|....:|.|.|.
Human   838 ANSSPGLGTPLKSPSLAKKDSLISESELSQYFA--HDVPG-PLSDFMVAGSEDEDHPGSGCSTSE 899

  Fly   692 DSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQ-TGSNQSSSSLSP-----PQQQQQQ 750
            :..|..: |..:|.|.....:..::.|.  ||:....|.| |.:.|:|...||     |..:|::
Human   900 EGSLPPS-TSTHKEPGKPRANSLVTLGS--HRASGLFHKQVTVARQASLPGSPQALRNPLLRQRK 961

  Fly   751 QQHYQPHHAS-----------LRHLGGIGGNVGSGRHHHHPLG---PSQLKFRQTKDNQQQEYGC 801
            ...|..:.||           :...|.:.|.:       .||.   |.::....:|       |.
Human   962 VGCYDANDASDEEEFDREGDCISLPGALPGPI-------RPLSEDDPRRVSISSSK-------GM 1012

  Fly   802 DEH----RTRR------------GS----ETLLPEYEPDA----------------------EQE 824
            |.|    |.|:            ||    |..:||...||                      ::|
Human  1013 DVHNQEERPRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKE 1077

  Fly   825 L-----ATKLS----------------RSFDMKEEGGTLLGDKGVRRHQSMQRLS---------A 859
            |     |.||.                .|...|.||   ||.    ||:.:.|:|         |
Human  1078 LSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEG---LGS----RHRPVARVSPHCKRSEAEA 1135

  Fly   860 EQNGGSTTEQTHEHNPNVVPDHR---GNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGA 921
            :.:|..|...|...|.....|.|   .::.:||...:|       |||..|..|
Human  1136 KPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQP-------GGAVEKESL----------- 1182

  Fly   922 AFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALI 986
                |.|..|...:.........|.|.:.:.|.    .|..||          .|.|..:|...:
Human  1183 ----GKLTTGDACVSTSCELASALSHLDASHLT----ENLPKA----------ASELGQQPMTEL 1229

  Fly   987 FLEAXHLLALPAS------DPLERQKLEFLYEWG-IDLTETPKPMPTP-IPLTKAKNPPPLPHEL 1043
            . .:..|::.|..      ||.:..     .:.| :...|.|....:| :...||::|..||||
Human  1230 D-SSSDLISSPGKKGAAHPDPSKTS-----VDTGQVSRPENPSQPASPRVTKCKARSPVRLPHE- 1287

  Fly  1044 HNNINSQYGSSAALSNHQPHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQGTPTTGTGA------ 1102
               .:...|..||.            |....:.:..|.|.||: |:.:.......|.||
Human  1288 ---GSPSPGEKAAA------------PPDYSKTRSASETSTPH-NTRRVAALRGAGPGAEGMTPA 1336

  Fly  1103 --------ATTGSKQQQQPGN 1115
                    .|:..::|..|||
Human  1337 GAVLPGDPLTSQEQRQGAPGN 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	26/89 (29%)
		PDZ_signaling	466..543	CDD:238492	27/82 (33%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	12/82 (15%)
		PDZ_signaling	886..971	CDD:238492	17/84 (20%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	20/79 (25%)
		PDZ_signaling	589..670	CDD:238492	27/109 (25%)
		PDZ_signaling	726..810	CDD:238492	31/130 (24%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900