DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dysc and LNX2

DIOPT Version :9

Sequence 1:NP_001261810.1 Gene:dysc / 39533 FlyBaseID:FBgn0264006 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_699202.1 Gene:LNX2 / 222484 HGNCID:20421 Length:690 Species:Homo sapiens


Alignment Length:699 Identity:147/699 - (21%)
Similarity:238/699 - (34%) Gaps:211/699 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 PFTSINHEEALKRC-------------------VQILKSSR-QISMTVRAPPTLNSTAPLHGFGP 396
            ||:|: .::.::||                   ::..|:|| |..:.....|||...|   |...
Human   115 PFSSV-CKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPA---GTLS 175

  Fly   397 PSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPMEYGGRRSERRD 461
            |..|.: .:.|.|:.....:|:.:..:...|...|..:..:..|...:|.|.|          ..
Human   176 PEADCL-GTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLP----------EG 229

  Fly   462 RIRRVEL-LIEPGQSLGLMIRGGVEYGL-GIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDV 523
            .|..:|: ...|...||:.|.||.|..| .|.:..|.:|.|..|.| |:.||:||:||..:..:|
Human   230 EITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNV 294

  Fly   524 THDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLL 588
            :|:.|              |.|...|  |.::.:        |..|.||.|.             
Human   295 SHNYA--------------RAVLSQP--CNTLHL--------TVLRERRFGN------------- 322

  Fly   589 PRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRE 653
             |.|                                 .|:.....||.:|       ...:::|:
Human   323 -RAH---------------------------------NHSDSNSPREEIF-------QVALHKRD 346

  Fly   654 R-DPYSVDRHRRKGDPARDLPVTADDLE--IIAATGRSPSSDSGLGMTVTDI-YKRPALQLPHRP 714
            . :...:...||..:|.   ....|.||  :.|..||..|:|..|.:...|: |..|.|      
Human   347 SGEQLGIKLVRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPEL------ 402

  Fly   715 MSAGPILHRS--------------QPASHYQTGSNQSSSSL--SPPQQQQQQQQH--------YQ 755
              |..|:..|              ||.:..:...|.||||.  :||....:...|        .|
Human   403 --AAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQ 465

  Fly   756 PHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQ-------QQEYGC--DEHRTRRGSE 811
            ..|.:::            :..|..||.:....|.:|..:       ...:||  .:.|.:|| :
Human   466 EKHITVK------------KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRG-D 517

  Fly   812 TLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRL----------SAEQNGGST 866
            .||.....|     .|.||.|     |...:|.........:::.|          :||:...:.
Human   518 VLLNINGID-----LTNLSHS-----EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTF 572

  Fly   867 TEQTHE--HNPNVV-----PDHRGNLHITVKKTKPI--LGIAIEGGANTKHP-LPRIINIHENGA 921
            :|..::  .:|:.|     |....:.|..|.:...:  .|.:|.||....|. .|..|.....|.
Human   573 SENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGT 637

  Fly   922 -AFEAGGLEVGQLILEVDGTKVEGLHHQEVARLIAECFANREKAEITFL 969
             |:..|.|:.|.:|:.|:|....|:.|..:..::.|   .|.|..:|.:
Human   638 PAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKE---QRNKVTLTVI 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dyscNP_001261810.1 PDZ_signaling 294..380 CDD:238492 9/47 (19%)
PDZ_signaling 466..543 CDD:238492 25/79 (32%)
HN_L-whirlin_R2_like 573..653 CDD:259823 7/79 (9%)
PDZ_signaling 886..971 CDD:238492 23/88 (26%)
LNX2NP_699202.1 mRING-HC-C3HC3D_LNX2 45..89 CDD:319694
modified RING-HC finger (C3HC3D-type) 50..87 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..224 3/25 (12%)
NPXY motif 208..211 1/2 (50%)
PDZ 230..316 CDD:214570 31/109 (28%)
PDZ 336..422 CDD:214570 21/103 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..455 9/36 (25%)
PDZ_signaling 466..542 CDD:238492 20/98 (20%)
PDZ_signaling 599..683 CDD:238492 23/86 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.