DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Tamalin

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_620249.1	Gene:	Tamalin / 192254	RGDID:	70554	Length:	394	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	118/504 - (23%)
Similarity:	167/504 - (33%)	Gaps:	182/504 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 SMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAA---------AAAAASGAGLP 431
            |...||.||.:        |||      |:.|||..|.::..||.         .|.|.||..||
  Rat    28 SEAARAAPTPS--------GPP------AAAAPPGAPGDELYAALEDYHPAELYRALAVSGGTLP 78

  Fly   432 FRQTCS--WMDRHGRPASPPMEYGGRRSERRDRIRRVELLIEPG--QSLGLMIRGGVEYGLG--- 489
            .|:...  |.:....|               ::.|:| |.:|.|  |:.|..|:   .|||.
  Rat    79 RRKGSGFRWKNFTQSP---------------EQQRKV-LTLEKGDNQTFGFEIQ---TYGLHHRE 124

  Fly   490 -------IFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGK 547
                   .||..|.:.|.|..:||..||.|..|||.:...:.|.|.|.          :|:..|.
  Rat   125 EQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVD----------IIKASGN 179

  Fly   548 VPHSCTSIEMEPWDAYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDA 612
            |      :.:|     :..||..|:                            ||..|:..
  Rat   180 V------LRLE-----TLYGTSIRK----------------------------AELEARLQ---- 201

  Fly   613 FVAVLLEMLDTYEKHTLVT---EIRELVFPEDRTRYDELVYRRERDPYSVD-----RHRRKGDPA 669
                       |.|.||..   |.|.|:..|.|..:..:|    :||...|     |....|  |
  Rat   202 -----------YLKQTLYEKWGEYRSLMVQEQRLVHGLVV----KDPSIYDTLESVRSCLYG--A 249

  Fly   670 RDLPVTADDLEIIAATGRS-PSSDSGLGMTVTDIY--------KRPALQLPHRPMSA-GPILHRS 724
            ..||.:.....::||.|.: ..|....|.|...:|        :..||..|..|..| ||
  Rat   250 GLLPGSLPFGPLLAAPGGARGGSRRAKGDTDDAVYHTCFFGGAEPQALPPPPPPARAPGP----- 309

  Fly   725 QPASHYQTGSNQSSSSLSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFR 789
                    ||.::.:|:..|..:....:     .||:| ..|.||..|.|       .|..|
  Rat   310 --------GSAETPASVLCPAPRATLSR-----SASVR-CAGPGGGGGGG-------APGAL--- 350

  Fly   790 QTKDNQQQEYGCDEHRTR-RGSETLLPEYEPDAEQELATKLSRSFDMKE 837
            .|:..:|...|....:|: |.....|.::.|.        |:||.:.:|
  Rat   351 WTEAREQALCGAGLRKTKYRSFRRRLLKFIPG--------LNRSLEEEE 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	1/3 (33%)
		PDZ_signaling	466..543	CDD:238492	26/88 (30%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	13/82 (16%)
		PDZ_signaling	886..971	CDD:238492
Tamalin	NP_620249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		12/36 (33%)
		PDZ_signaling	99..184	CDD:238492	29/104 (28%)
		Interaction with PSCD3. /evidence=ECO:0000250	180..257		26/136 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810