DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Lnx1

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	451	Identity:	95/451 - (21%)
Similarity:	155/451 - (34%)	Gaps:	143/451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 PGRGS-AYLSSSPASHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQSS 238
            ||..: ||:||.......|        :::.|||       ||..:.||.            :.|
Mouse   181 PGLDNPAYVSSVEDGEPVA--------NSSDSGR-------SNRTRARPF------------ERS 218

  Fly   239 SVPTSSYHYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNI-----HELTTRTVS 298
            ::.:.|:...|.......||      .|.....:.:.:.|:...:.:||.:     |.:....::
Mouse   219 TMRSRSFKKINRALSALRRT------KSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEIT 277

  Fly   299 MSRDQQIDHGFGICVK--GGKDSGL-GVYISRIEENSVAERAG-LRPGDTILEVNGTPFTSINHE 359
            ..:..:.|....:.::  ||.::.| .:.|..|..:.|..|.| |.|||.||:|||...:::.|.
Mouse   278 SIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 342

  Fly   360 EALKRCVQILKSSRQI-SMTVRAPPTLNSTAPLH---GFGPPSRDPMYASMAPPLHPQNQAAAAA 420
            .|    |::|:...|: .:||.......|.:..|   .:||  ||..:..:.....|:.|.....
Mouse   343 YA----VRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGP--RDDSFHVILNKSSPEEQLGIKL 401

  Fly   421 AAAAASGAGLPFRQTCSWM-DRHGRPASPPMEYGGRRSERRDRI--------------------- 463
            ...........|......: ||||            :.|..||:
Mouse   402 VRRVDEPGVFIFNVLNGGVADRHG------------QLEENDRVLAINGHDLRFGSPESAAHLIQ 454

  Fly   464 ---RRVELLI-------------------------------------------------EPGQSL 476
               |||.|::                                                 :|.:||
Mouse   455 ASERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESL 519

  Fly   477 GLMIRGGV---EYGLGIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDVTHDEAVGQLK 533
            |:.:.||.   |:.|.|:|..|:...|..|.| :..||.:|.|||....:|:..|||..||
Mouse   520 GMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	24/90 (27%)
		PDZ_signaling	466..543	CDD:238492	28/121 (23%)
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220		13/61 (21%)
		NPXY motif	185..188		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		18/90 (20%)
		PDZ_signaling	276..360	CDD:238492	24/87 (28%)
		PDZ_signaling	384..464	CDD:238492	14/91 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500		0/18 (0%)
		PDZ_signaling	506..589	CDD:238492	26/75 (35%)
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810