DRSC/TRiP Functional Genomics Resources

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Protein Alignment dysc and FRMPD2

DIOPT Version :9

Sequence 1:NP_001261810.1 Gene:dysc / 39533 FlyBaseID:FBgn0264006 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_001018081.4 Gene:FRMPD2 / 143162 HGNCID:28572 Length:1309 Species:Homo sapiens


Alignment Length:735 Identity:166/735 - (22%)
Similarity:231/735 - (31%) Gaps:239/735 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 SHMAAGTAGTLPTSTAASGRSMGQHASSNGNKKRPISPEQVLRMFGATQS-------SSVPTSSY 245
            |.:.....|.|.||.........:.|.:.|..:.|.:..:.|:.....|.       |..|..|.
Human   689 SRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSM 753

  Fly   246 HYSNGGTRDRDRTGRRSPASSPPSTTHQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFG 310
            |..:...|      |:|..:.|         .||..|              |::.||..  .|||
Human   754 HAGSKNNR------RKSFIAEP---------GREIVR--------------VTLKRDPH--RGFG 787

  Fly   311 ICVKGGKDSGL---GVYISRIEENSVAERA-GLRPGDTILEVNGTPFTSINHEEALKRCVQILKS 371
            ..:..|:.||.   |::||.|.....||:| .::||..||.:|...........|::   .|..|
Human   788 FVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR---MIQNS 849

  Fly   372 SRQISMTVRAPPTL---------NSTAPLHGFGPPSRDPMYASMAPPL--HPQNQAAAAAAAAAA 425
            ...|.:.:.....:         ||||   ..|..|.|.:.......|  |.|:|.........|
Human   850 PDNIELIISQSKGVGGNNPDEEKNSTA---NSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMA 911

  Fly   426 SGAGL--PFRQTCSWMDRHGR----PASPPMEYGGRRSERRDRIRRVELLIEPGQSLGLMIRGG- 483
            ....|  ..|...|::...|.    |.|||....|       .|..|||:.|.| :||..:.|| 
Human   912 GVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAG-------EIYFVELVKEDG-TLGFSVTGGI 968

  Fly   484 ---VEYGLGIFVTGVDKDSVADRSG-LMIGDEILEVNGQSFLDVTHDEAV------GQ---LKYH 535
               |.|| ||:|..:.....|.:.| ::.||.:|:|:|.....:||.:||      ||   |...
Human   969 NTSVPYG-GIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLE 1032

  Fly   536 KR---------------------MSLVIRDVGKVPHSCTSIEMEPWDAYSPTGTRARRKGQIATM 579
            :|                     :|||....|: |.||.|:...|               :....
Human  1033 RRVPRSTQQCPSANDSMGDERTAVSLVTALPGR-PSSCVSVTDGP---------------KFEVK 1081

  Fly   580 VEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTR 644
            :::.|..|                        .|..|.:|........:.:..|:.| ||     
Human  1082 LKKNANGL------------------------GFSFVQMEKESCSHLKSDLVRIKRL-FP----- 1116

  Fly   645 YDELVYRRERDPYSVDRHRRKGDPARDL-PVTADDLEIIAATGRSPSS---------DSGLGMTV 699
                                 |.||.:. .:.|.|: |:|..|||...         ..|....|
Human  1117 ---------------------GQPAEENGAIAAGDI-ILAVNGRSTEGLIFQEVLHLLRGAPQEV 1159

  Fly   700 TDIYKRP---AL-------QLPHRPMSA--------------GPILHRSQPASHYQTGSNQSSSS 740
            |.:..||   ||       |.|.  :||              .|||  .|..|...:.|..:...
Human  1160 TLLLCRPPPGALPELEQEWQTPE--LSADKEFTRATCTDSCTSPIL--DQEDSWRDSASPDAGEG 1220

  Fly   741 LS--PPQQQ------QQQQQHYQPHHASLRHLGGIGGNVGSGRHH------HHPLGPSQLKFRQT 791
            |.  |...|      |..|...:|..:||.|         |...|      |.....|.|.....
Human  1221 LGLRPESSQKAIREAQWGQNRERPWASSLTH---------SPESHPHLCKLHQERDESTLATSLE 1276

  Fly   792 KDNQQQEYG-CDEHRTRRGS 810
            ||.:|..|. ||..|..|.|
Human  1277 KDVRQNCYSVCDIMRLGRYS 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dyscNP_001261810.1 PDZ_signaling 294..380 CDD:238492 25/89 (28%)
PDZ_signaling 466..543 CDD:238492 33/111 (30%)
HN_L-whirlin_R2_like 573..653 CDD:259823 9/79 (11%)
PDZ_signaling 886..971 CDD:238492
FRMPD2NP_001018081.4 KIND 15..197 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..302
B41 346..550 CDD:214604
FERM_C_PTPH13 546..647 CDD:270008
PDZ_signaling 773..857 CDD:238492 26/102 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..880 4/23 (17%)
PDZ 947..1034 CDD:214570 30/88 (34%)
PDZ 1078..1167 CDD:214570 23/140 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1228 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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