DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and Il16

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_006229550.1	Gene:	Il16 / 116996	RGDID:	1583872	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	1345	Identity:	251/1345 - (18%)
Similarity:	395/1345 - (29%)	Gaps:	482/1345 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WSARPYGYNATAAAAASFGLGPSMGGTQSSSSVPTGGSAGLSGHHLRSSGAPGPSSFEAEDIGMA 99
            |...|...|.|.||||.    ||...|.                      .|.|...|.:..|:.
  Rat    60 WHLLPGQANRTHAAAAK----PSSSTTH----------------------RPRPGEQERKKRGLT 98

  Fly   100 FGM-ISPPPGSGPYVGSSAAAGGSRVGNSTSSLRGAGGRSGLYYSPPGTSY-----TIVERPHSP 158
            ..: :.|...||....|:.....||      ||.....::....|.|...|     |.:.:....
  Rat    99 SSLRMEPHSHSGKSRKSTKFRSISR------SLILCNAKTSDDSSSPDEKYPDPFETSLCQDKEG 157

  Fly   159 HYYFNSAGVPTKGGSLPGRGSAYLSSSPASHMAAGT-------------AGTLPTSTAASGRSMG 210
            .::.:.....|....|.......|:|..|...|||:             ..:..:|...:|:|..
  Rat   158 FFHSSMQLADTSEAGLSNIPDLALASEAAQLQAAGSDRGKHCRKMFFLKESSTTSSKEKAGKSEA 222

  Fly   211 QHAS------------SNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSP 263
            |.::            ||.....|.|..::  .|..|:.|:.||....||....|.........|
  Rat   223 QSSNFLFPKACHQRTRSNSTSVNPYSAREM--DFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYP 285

  Fly   264 ASSPPSTTHQIYRDRERERDRSVPNIHELT-------TRTVSMSRDQQIDHGFGICVKGGKDS-- 319
            .|.....|          |..|...:.:|:       ...:.:.:.|.  .|.|..:.|||||
  Rat   286 VSGTARPT----------RSLSTAQLGQLSGGLQASVISNIVLMKGQA--KGLGFSIVGGKDSIY 338

  Fly   320 -GLGVYISRIEENSVAERAG-LRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTVRAP 382
             .:|:|:..|.....|...| |:.||.|||:||.....:.|::||::..|..|.  .:::|||..
  Rat   339 GPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESIAGLTHQDALQKFKQAKKG--LLTLTVRTR 401

  Fly   383 PTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGA--GLPFRQTCSWMDRHGRP 445
            .|.          |||   :.:.::|||       ..:.:::..||  ..||...        .|
  Rat   402 LTT----------PPS---LCSHLSPPL-------CRSLSSSTCGAQDSSPFSLE--------SP 438

  Fly   446 ASPPMEYGGRRSERRDRIR---RVELLIEPGQSLGLMIRGGVEYGL----------GIFVTGVDK 497
            |||       .|..:...|   .|.|..|.|..||:        ||          |:|:..:..
  Rat   439 ASP-------ASTAKPNYRIMVEVSLKKEAGVGLGI--------GLCSIPYFQCISGVFIHTLSP 488

  Fly   498 DSVADRSG-LMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPWD 561
            .|||...| |..||||:|:|......:|.:|....|.:        .|.|.||
  Rat   489 GSVAHLDGRLRCGDEIVEINDSPVHCMTLNEVYTILSH--------CDPGPVP------------ 533

  Fly   562 AYSPTGTRARRKGQIATMVEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEK 626
                                    .::.||....:|    |...|.....|...|....    |:
  Rat   534 ------------------------IIVSRHPDPQVS----EQQLKEAVAQAVEGVKFGK----ER 566

  Fly   627 HTLVTE-IRELVFPEDRTRYDELVYRRERDPYSVDRHRRKGDPARDLPV--TADDLEIIAATGRS 688
            |....| ::.|    :.:.:......:||:.:|...|||    |:.:.|  ::|...:..:.|.|
  Rat   567 HQWSLEGVKRL----ESSWHGRPTLEKEREKHSAPPHRR----AQKIMVRSSSDSSYMSGSPGGS 623

  Fly   689 PSS-------DSGLGMTVTDIY-----KRPALQLPHRPMSAGPILHRS----------------- 724
            |.|       ..|.|.|.:...     :.|...:|.||....|.|..|
  Rat   624 PCSAGAELQPSEGEGSTHSPSLPPGEEQEPCPGVPSRPHQESPPLSESLERDSHPPLKLKNSFEI 688

  Fly   725 -----------------------------------QPASHY------------------------ 730
                                               .|:.|.
  Rat   689 LVRKPTSTKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETRELLPLLLQEDTAGRT 753

  Fly   731 ---------QTGSNQSSSSL-SPPQQQQQQQQHYQP-HHASLRH--------------------- 763
                     ...|.|:|||. ..|::....:....| .|..|:.
  Rat   754 LCTAACCPGPAASTQTSSSTEGEPRRSASPETPASPGKHPLLKRQARMDYSFDSTTEDPWVRISD 818

  Fly   764 -LGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSETLLPEYE--------- 818
             :..:...:.|..|.|.||.|:.....:.......|.|..:..|..|:..:....:
  Rat   819 CIKNLFSPIMSENHSHMPLQPNASLGEEDGTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKGPP 883

  Fly   819 -------------------PDAEQ--ELATKLSRSFDMKEEGG--TLLGDKGVRRHQSMQRLSAE 860
                               |:..:  |:|:.:..:...::..|  :......:|     ||:|:.
  Rat   884 VAPKPAWFRQSLKGLRNRVPETRRAPEVASAIQTTPVSRDASGPQSQASSSSIR-----QRISSF 943

  Fly   861 QNGGSTTEQTHEHNPNVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEA 925
            :|.||:.          :|| ||...::::.|         .|..|:.|
  Rat   944 ENFGSSQ----------LPD-RGVQRLSLQPT---------SGETTRLP---------------- 972

  Fly   926 GGLEVGQLI-LEVDGTKVEGLHHQEVARLIAECFANREKAEITFLVVEAKKSNLEPKPTALIFLE 989
            |..:.|:.. |...||||...|.|                             .|.:|.:..|..
  Rat   973 GKQDEGRFSGLPAQGTKVTAKHRQ-----------------------------TEVEPPSTTFPN 1008

  Fly   990 AXHLLALPASDPLERQKLEFLYEWGIDLTETPKPMPTPIPLTKAKNPPPLPHELHNNINSQYGSS 1054
            :..:     .||              |::|:|.|...|.|  ||.:|.||...|........|..
  Rat  1009 SSEV-----GDP--------------DMSESPPPGQRPNP--KALSPDPLLRLLTTQTEDTQGPG 1052

  Fly  1055 AALSNHQPHQHTHPHPQQQQQQQQHSNTKTPNTNSNKTQG---------------TPTTGT-GAA 1103
            ..:    |.|.....|..:.|..:   ||..:..|:|...               .|::.: |..
  Rat  1053 FKM----PSQRARSFPLTRTQSYE---TKLLDEKSSKLYSISSQLSSAVMKSLLCLPSSASCGQI 1110

  Fly  1104 TTGSKQQQQPGNTTNTPTKAS--REATPTREQHHQHATPTREHQQ 1146
            |...|::..|.:..|....|.  .||..:......:.:..||:.:
  Rat  1111 TCIPKERVSPKSPCNNSAAAEGFGEAVASDTGFSLNLSELREYSE 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	27/89 (30%)
		PDZ_signaling	466..543	CDD:238492	24/87 (28%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	11/80 (14%)
		PDZ_signaling	886..971	CDD:238492	13/85 (15%)
Il16	XP_006229550.1	PDZ_signaling	316..391	CDD:238492	25/76 (33%)
		PDZ_signaling	454..536	CDD:238492	28/133 (21%)
		PDZ_signaling	1207..1284	CDD:238492
		PDZ	1329..1413	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900