DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and whrnb

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005172005.1	Gene:	whrnb / 100534775	ZFINID:	ZDB-GENE-060526-377	Length:	946	Species:	Danio rerio

Alignment Length:	935	Identity:	251/935 - (26%)
Similarity:	371/935 - (39%)	Gaps:	287/935 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 SMGQHASSNGNKKRPISPEQVLRMFGATQSSSVPTSSYHYSNGGTRDRDRTGRRSPA--SSPPST 270
            |...||.::.....|.|.:.     |.:..|..|.|.:..|..||         :||  ...||.
Zfish   124 STNAHAGASSVHFAPQSDQA-----GPSHGSLRPASVFSTSAEGT---------APALMLEAPSE 174

  Fly   271 THQIYRDRERERDRSVPNIHELTTRTVSMSRDQQIDHGFGICVKGGKDSGLGVYISRIEENSVAE 335
            ..|:...|.:.        ||                |.|..::||.:.|:|:|:|.:|..|.||
Zfish   175 IRQVTLKRSKS--------HE----------------GLGFSIRGGSEHGVGIYVSLVEPGSSAE 215

  Fly   336 RAGLRPGDTILEVNGTPFTSINHEEALKRCVQILKSSRQISMTV----RAPPTLNSTAPLHGFGP 396
            |.|||.||.|::||...|..:.|.||:|    :||.|:::||:|    |.|
Zfish   216 REGLRVGDQIMKVNNVVFDRVTHGEAVK----VLKGSKKLSMSVCSMGRIP-------------- 262

  Fly   397 PSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQTCSWMDRHGRPASPPME------YGGR 455
                                           .|.......:|:|..||..|||.:      .|||
Zfish   263 -------------------------------GGYVTNHVYTWVDPQGRSVSPPPDLVEQHSLGGR 296

  Fly   456 RSE-RRDRIRRVELLIEPGQSLGLMIRGGVEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQS 519
            .|: ..:..::|.:.::.|:|||||||||.||.|||::||||:.|.|:.|||.:||:||||||::
Zfish   297 LSDLHTNTEKKVNISLDDGRSLGLMIRGGAEYALGIYITGVDRGSAAEYSGLKVGDQILEVNGRN 361

  Fly   520 FLDVTHDEAVGQLKYHKRMSLVIRDVGKVPHSCTSIEMEPW---------DAYS----------P 565
            |..:.|||||..||..:.|.:.|:|||::||:.|.::...|         .|.|          .
Zfish   362 FRSICHDEAVQILKNSRHMLMTIKDVGRLPHARTVVDETKWIPSAQIAESSANSNSQSILSVDVG 426

  Fly   566 TGTRARR---KGQIATM----------VEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVL 617
            ||:..:.   ||.:..:          :||:|..||......::||||.||....:.::.....|
Zfish   427 TGSLGKSVCCKGVVPAVGAVRAGAWSSLEEQAFMLLTETERQTMSYYIQEYQRAHIGVEPLAMAL 491

  Fly   618 LEMLDTYEKHTLVTEIRELVFPEDRTRYDELVYRRERDPYSVDRHRRKG----------DPARDL 672
            .|:.:|:.|.:|:.|:|.||.|:|..|:|..|..||.:.:.. ||..:|          .|...:
Zfish   492 FELFNTHAKLSLLAEVRTLVAPQDLERFDGQVLLREMEAWRA-RHGGQGLLHPDSICITQPEGLV 555

  Fly   673 PVTADDLEIIAATGRSPSSDS-----GLGMTVTDIYKRPALQLPHRPMSA----------GPILH 722
            |..|..:.    ||.|..|.|     |..|.:..:...|.:.|....:|:          .||.|
Zfish   556 PSPACQMN----TGGSGYSKSECRLDGSLMPLETLNSLPDVALDKVQVSSESPPSFKPPPPPIRH 616

  Fly   723 RSQPASHYQTGSNQSSSSL---SPPQQQQQQ----------QQHYQP------------------ 756
            .|......:..|..|.::|   :|.::.|:.          ..|..|
Zfish   617 ASPKTQTKRPSSKLSQTNLFFTAPFRRHQENHTLNHSHLSCSSHTSPCTIHHTTSPCSISHTPPP 681

  Fly   757 ---HHASLR----HLGGIGG--------NVGSGRHHHHP--------------------LGPSQL 786
               ||:|.|    |.....|        |..:|....||                    |.||.|
Zfish   682 CSHHHSSPRTSSYHSSPSSGRDLVQFLMNRQAGTLSPHPESPNRSRDGTPMISPRSSPSLSPSLL 746

  Fly   787 K------FRQTKDNQQQEYGCDEHRTRRGSETLLPEYEPDAEQELATKLSRSFDMKEEGGTLLGD 845
            .      ..:..|.....:.|       |.:...||...|..|......:.| .:.:.|.||..|
Zfish   747 MPAPPPCSPERLDGSPSTHSC-------GPQHAEPETTEDRPQPQLRGATLS-QLSDSGQTLSED 803

  Fly   846 KGV----------------------------RRHQSMQRLSAEQNGGSTTEQTHEHNPNVVPDHR 882
            .||                            ||.:.:.:.:|:|.|            .:.|
Zfish   804 SGVDIAEAGGLSKDSSPRPGKPPFQQFTGDTRRAEGLAQATAKQMG------------MMEP--- 853

  Fly   883 GNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGTKVEGLHH 947
              :.:.|.|....||||:||||||:.|||||..|.:.|:....|.|.|||:||||:|..::|:.|
Zfish   854 --ILVRVPKCASTLGIAVEGGANTRQPLPRIATIQKGGSVHLCGQLRVGQVILEVNGVSLKGMEH 916

  Fly   948 QEVARLIAECFANREKAEITFLVVE 972
            ::..|||||.|..::|..:.||::|
Zfish   917 RDATRLIAEAFKTKDKDHVDFLIME 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	32/89 (36%)
		PDZ_signaling	466..543	CDD:238492	42/76 (55%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	27/89 (30%)
		PDZ_signaling	886..971	CDD:238492	40/84 (48%)
whrnb	XP_005172005.1	HN_L-whirlin_R1_like	24..101	CDD:259822
		PDZ_signaling	175..256	CDD:238492	35/108 (32%)
		PDZ_signaling	305..385	CDD:238492	42/79 (53%)
		HN_L-whirlin_R2_like	454..527	CDD:259823	25/72 (35%)
		PDZ_signaling	853..939	CDD:238492	40/90 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7912
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2724
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	1	1.000	-	-		FOG0006185
OrthoInspector	1	1.000	-	-		otm24436
orthoMCL	1	0.900	-	-		OOG6_107411
Panther	1	1.100	-	-	O	PTHR23116
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5115
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970