DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and SYNJ2BP-COX16

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001189476.1	Gene:	SYNJ2BP-COX16 / 100529257	HGNCID:	48350	Length:	191	Species:	Homo sapiens

Alignment Length:	126	Identity:	36/126 - (28%)
Similarity:	63/126 - (50%)	Gaps:	17/126 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 LTTRTVSMSRDQQIDHGFGICVKGGKD-----SGLGVYISRIEENSVAERAG-LRPGDTILEVNG 350
            :|...::::|...   |.|..:.||.|     :..|:|:|||:||..|...| |:.||.||.|||
Human     9 VTEEEINLTRGPS---GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70

  Fly   351 TPFTSINHEEALKRCVQILKSSRQISMTVRAPPTLN-STAPL--HGFGPPSRDPMYASMAP 408
            ....::.|::|    |.:.::: ..::::|....|. ...|:  .|.|.||..|::..:.|
Human    71 QDLKNLLHQDA----VDLFRNA-GYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVP 126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	26/91 (29%)
		PDZ_signaling	466..543	CDD:238492
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492
SYNJ2BP-COX16	NP_001189476.1	PDZ_signaling	13..97	CDD:238492	27/91 (30%)
		DegQ	<16..77	CDD:223343	23/63 (37%)
		COX16	<133..173	CDD:290843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900