DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dysc and whrna

DIOPT Version :9

Sequence 1:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	942	Identity:	254/942 - (26%)
Similarity:	387/942 - (41%)	Gaps:	265/942 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 NGNKKRPISPEQVLRMFGATQSSSVPTSSY----HYSNGG--------TRDRDRTGRRSPASSPP 268
            |...||.:.|  :||:.       :|.|..    .|::.|        .|:.|..|.:..|:|.|
Zfish    73 NVPSKRQLLP--MLRLV-------IPRSDQLLFDQYTSEGLYLKSEIHARNGDPDGAQEGANSSP 128

  Fly   269 STTHQIYRDRERERDRSVPNIHELTTRTVSMSRD---------------------QQI------- 305
              ||.......:...|..|:       ::|.|.|                     :|:
Zfish   129 --THGANFPASQVALRGSPD-------SISTSSDGTATLIPLLGRNFLPEPPGEIRQVILKRHKS 184

  Fly   306 DHGFGICVKGGKDSGLGVYISRIEENSVAERAGLRPGDTILEVNGTPFTSINHEEALKRCVQILK 370
            :.|.|..::||.:.|:|:|:|.:|..|:||:.|||.||.|::||...|..:.|.:|:|    :||
Zfish   185 NEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRMGDQIMKVNDKVFDRVTHADAVK----VLK 245

  Fly   371 SSRQISMTVRAPPTLNSTAPLHGFGPPSRDPMYASMAPPLHPQNQAAAAAAAAAASGAGLPFRQT 435
            .|:::.|:||:               ..|.|                          .|......
Zfish   246 GSKKLCMSVRS---------------VGRIP--------------------------GGYITNHV 269

  Fly   436 CSWMDRHGRPASPPMEYGG-------RRSERRDRI----------RRVELLIEPGQSLGLMIRGG 483
            .:|:|..||..|||.:...       |||..:.|.          ::|.|:::.|:|||||||||
Zfish   270 YTWVDPQGRSVSPPPDLLAEHRSATLRRSNSQGRSHMQLLQDGDEKKVNLVLDDGRSLGLMIRGG 334

  Fly   484 VEYGLGIFVTGVDKDSVADRSGLMIGDEILEVNGQSFLDVTHDEAVGQLKYHKRMSLVIRDVGKV 548
            .||.|||::||||:.|.|:..|:.:||:||||||:|||.:.|||||..||....:.:.::|||::
Zfish   335 AEYSLGIYITGVDRGSAAECGGIKVGDQILEVNGRSFLSIPHDEAVRVLKSSHHLMMTVKDVGRL 399

  Fly   549 PHSCTSIEMEPWDAYS----------------PTGTRARRKG------------------QIATM 579
            ||:.|.:....|.|.|                ..|.....||                  |...|
Zfish   400 PHTRTVVGETKWIASSQISDSSASSSVTGISLDQGASTSAKGGFYKGVAGSQVTLSSLVNQSRAM 464

  Fly   580 VEEKARSLLPRHHFASLSYYIAEYSAKAMTIDAFVAVLLEMLDTYEKHTLVTEIRELVFPEDRTR 644
            :||:||.||......::.|||.||....:.::..|..|.|:.:|:.|.:|::|:|.:|.|:|..:
Zfish   465 LEEQARHLLTEPERQTMGYYIQEYRDGHVGVEQLVMALFELFNTHAKFSLLSEVRGIVTPQDVEK 529

  Fly   645 YDELVYRRERDPYSVDRHRRKGDPAR--------DLPVT--ADDLEIIAATGRSPSSDSGLG--- 696
            :|.||.|||.|....    |:|..|.        ..|.|  :.....:..|..|.:.:.|:.
Zfish   530 FDGLVLRREIDALKA----RQGGGAGFQDSFSMVSYPDTLASSSASFMTNTTLSSARNDGVAENN 590

  Fly   697 --------------MTVTDIYKR----PALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSS--- 740
                          :::.:::..    |:.:.|..|   |.....|:.|:..:..|:.||.|
Zfish   591 GEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPPPP---GLQRRPSRKATLSKRPSSSSSQSGLY 652

  Fly   741 -LSPPQQQQQQQQHYQPHHASLRHLGGIGGNVGSGR---HHHHPLGPSQLKFRQTKDNQQQEY-- 799
             .:|.:...::.:|.:...|.:...|.:..:|.:.:   ...||:||........|....|..
Zfish   653 FTAPSRSHTRESKHPKAPKAFMSPPGTLKIDVPASQLSVVSQHPIGPFPRVQSPNKAKPAQSSSP 717

  Fly   800 -------------------------GCDEHRTRRGS---------ETLLPEYEPDAE------QE 824
                                     .|.:..|....         |...|..|||..      |.
Zfish   718 IPPPAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHFVMVEVHRPNAEPDVNEVRPLPQV 782

  Fly   825 LATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAE--------------QNGGSTTEQTHEHNP 875
            ....||:   :.:.|.||..|.||...:| .|||.:              ..||.|:.:     |
Zfish   783 RGGTLSQ---LSDSGQTLSEDSGVDIPES-GRLSKDTSPRPARTRAPRDGHGGGETSAK-----P 838

  Fly   876 NVVPDHRGNLHITVKKTKPILGIAIEGGANTKHPLPRIINIHENGAAFEAGGLEVGQLILEVDGT 940
            ..:.:....| :.|.|:...|||||||||||:.|||||:.|...|:|...|.|:|||:||||:|.
Zfish   839 PGLLEPMSTL-VRVAKSASTLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGQVILEVNGV 902

  Fly   941 KVEGLHHQEVARLIAECFANREKAEITFLVVE 972
            .:.|..|:|.||||||.|..:||..|.||:.|
Zfish   903 SLRGKEHREAARLIAEAFKTKEKDYIDFLITE 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492	32/113 (28%)
		PDZ_signaling	466..543	CDD:238492	42/76 (55%)
		HN_L-whirlin_R2_like	573..653	CDD:259823	30/97 (31%)
		PDZ_signaling	886..971	CDD:238492	46/84 (55%)
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822	9/37 (24%)
		PDZ_signaling	174..255	CDD:238492	29/84 (35%)
		PDZ_signaling	314..394	CDD:238492	42/79 (53%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	28/78 (36%)
		PDZ_signaling	848..919	CDD:238492	40/71 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7912
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2724
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	1	1.000	-	-		FOG0006185
OrthoInspector	1	1.000	-	-		otm24436
orthoMCL	1	0.900	-	-		OOG6_107411
Panther	1	1.100	-	-	O	PTHR23116
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4929
SonicParanoid	1	1.000	-	-		X5115
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900